Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility

It has been shown that sera from chagasic patients contain an antibody which binds to β-adrenoceptors of myocardium and modulates their activity. Chagasic IgG triggered a marked stimulation of myocardial contractility with an increase in intramyocardial cyclic AMP and inhibition of (Na+ + K+)-ATPase...

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Autores principales:	Pascual, J., Borda, E., Cossio, P., Arana, R., Sterin-Borda, L.
Formato:	JOUR
Materias:	adenosine triphosphatase (potassium sodium) beta adrenergic receptor chagas disease antibody cyclic AMP immunoglobulin G isoprenaline ouabain propranolol theophylline unclassified drug article bird blood and hemopoietic system Chagas disease dose response drug antagonism drug mechanism drug response enzyme modification erythrocyte etiology guinea pig heart heart contraction human muscle muscle contractility priority journal rat turkey (bird) Adenylate Cyclase Animals Chagas Cardiomyopathy Chagas Disease Cyclic AMP Guinea Pigs Humans Immunoglobulin G Male Myocardial Contraction Myocardium Na(+)-K(+)-Exchanging ATPase Rats Sarcolemma Turkeys
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00062952_v35_n21_p3839_Pascual
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00062952_v35_n21_p3839_Pascual2023-10-03T14:04:14Z Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility Pascual, J. Borda, E. Cossio, P. Arana, R. Sterin-Borda, L. adenosine triphosphatase (potassium sodium) beta adrenergic receptor chagas disease antibody cyclic AMP immunoglobulin G isoprenaline ouabain propranolol theophylline unclassified drug article bird blood and hemopoietic system Chagas disease dose response drug antagonism drug mechanism drug response enzyme modification erythrocyte etiology guinea pig heart heart contraction human muscle muscle contractility priority journal rat turkey (bird) Adenylate Cyclase Animals Chagas Cardiomyopathy Chagas Disease Cyclic AMP Guinea Pigs Humans Immunoglobulin G Male Myocardial Contraction Myocardium Na(+)-K(+)-Exchanging ATPase Rats Sarcolemma Turkeys It has been shown that sera from chagasic patients contain an antibody which binds to β-adrenoceptors of myocardium and modulates their activity. Chagasic IgG triggered a marked stimulation of myocardial contractility with an increase in intramyocardial cyclic AMP and inhibition of (Na+ + K+)-ATPase activity. both the mechanical and enzymatic effects of the IgG could be prevented by β-adrenoceptor blockade or after the absorption of chagasic IgG with turkey red blood cells. In contrast, guinea pig red blood cells were unable to remove the β-reactivity of chagasic IgG. These findings suggest that the IgG from chagasic patients increases myocardial contractility by behaving as a β-agonist. This effect is likely related to stimulation of the adenylate cyclase coupled to the cardiac β-adrenoceptor. © 1986. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00062952_v35_n21_p3839_Pascual
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	adenosine triphosphatase (potassium sodium) beta adrenergic receptor chagas disease antibody cyclic AMP immunoglobulin G isoprenaline ouabain propranolol theophylline unclassified drug article bird blood and hemopoietic system Chagas disease dose response drug antagonism drug mechanism drug response enzyme modification erythrocyte etiology guinea pig heart heart contraction human muscle muscle contractility priority journal rat turkey (bird) Adenylate Cyclase Animals Chagas Cardiomyopathy Chagas Disease Cyclic AMP Guinea Pigs Humans Immunoglobulin G Male Myocardial Contraction Myocardium Na(+)-K(+)-Exchanging ATPase Rats Sarcolemma Turkeys
spellingShingle	adenosine triphosphatase (potassium sodium) beta adrenergic receptor chagas disease antibody cyclic AMP immunoglobulin G isoprenaline ouabain propranolol theophylline unclassified drug article bird blood and hemopoietic system Chagas disease dose response drug antagonism drug mechanism drug response enzyme modification erythrocyte etiology guinea pig heart heart contraction human muscle muscle contractility priority journal rat turkey (bird) Adenylate Cyclase Animals Chagas Cardiomyopathy Chagas Disease Cyclic AMP Guinea Pigs Humans Immunoglobulin G Male Myocardial Contraction Myocardium Na(+)-K(+)-Exchanging ATPase Rats Sarcolemma Turkeys Pascual, J. Borda, E. Cossio, P. Arana, R. Sterin-Borda, L. Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility
topic_facet	adenosine triphosphatase (potassium sodium) beta adrenergic receptor chagas disease antibody cyclic AMP immunoglobulin G isoprenaline ouabain propranolol theophylline unclassified drug article bird blood and hemopoietic system Chagas disease dose response drug antagonism drug mechanism drug response enzyme modification erythrocyte etiology guinea pig heart heart contraction human muscle muscle contractility priority journal rat turkey (bird) Adenylate Cyclase Animals Chagas Cardiomyopathy Chagas Disease Cyclic AMP Guinea Pigs Humans Immunoglobulin G Male Myocardial Contraction Myocardium Na(+)-K(+)-Exchanging ATPase Rats Sarcolemma Turkeys
description	It has been shown that sera from chagasic patients contain an antibody which binds to β-adrenoceptors of myocardium and modulates their activity. Chagasic IgG triggered a marked stimulation of myocardial contractility with an increase in intramyocardial cyclic AMP and inhibition of (Na+ + K+)-ATPase activity. both the mechanical and enzymatic effects of the IgG could be prevented by β-adrenoceptor blockade or after the absorption of chagasic IgG with turkey red blood cells. In contrast, guinea pig red blood cells were unable to remove the β-reactivity of chagasic IgG. These findings suggest that the IgG from chagasic patients increases myocardial contractility by behaving as a β-agonist. This effect is likely related to stimulation of the adenylate cyclase coupled to the cardiac β-adrenoceptor. © 1986.
format	JOUR
author	Pascual, J. Borda, E. Cossio, P. Arana, R. Sterin-Borda, L.
author_facet	Pascual, J. Borda, E. Cossio, P. Arana, R. Sterin-Borda, L.
author_sort	Pascual, J.
title	Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility
title_short	Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility
title_full	Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility
title_fullStr	Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility
title_full_unstemmed	Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility
title_sort	modification of sarcolemmal enzymes by chagasic igg and its effect of cardiac contractility
url	http://hdl.handle.net/20.500.12110/paper_00062952_v35_n21_p3839_Pascual
work_keys_str_mv	AT pascualj modificationofsarcolemmalenzymesbychagasicigganditseffectofcardiaccontractility AT bordae modificationofsarcolemmalenzymesbychagasicigganditseffectofcardiaccontractility AT cossiop modificationofsarcolemmalenzymesbychagasicigganditseffectofcardiaccontractility AT aranar modificationofsarcolemmalenzymesbychagasicigganditseffectofcardiaccontractility AT sterinbordal modificationofsarcolemmalenzymesbychagasicigganditseffectofcardiaccontractility
_version_	1807324045117489152

Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility

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