Tryptophan metabolism in experimental porphyria
Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptoph...
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00062952_v16_n10_p1967_Garcia |
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todo:paper_00062952_v16_n10_p1967_Garcia2023-10-03T14:04:13Z Tryptophan metabolism in experimental porphyria Garcia, A.F. Grinstein, M. kynurenine tryptophan tryptophan 2,3 dioxygenase animal article chromatography enzymology liver male metabolism porphyria rat urine Animal Chromatography Kynurenine Liver Male Porphyria Rats Tryptophan Tryptophan Oxygenase Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptophan pyrrolase activity is diminished in porphyric animals. This is interpreted as being the result, at least in part, of a competitive inhibition between the porphyrins accumulated in the liver during the state of porphyria and the tryptophan pyrrolase heme coenzyme, for the tryptophan pyrrolase apoenzyme. © 1967. Fil:Garcia, A.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Grinstein, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00062952_v16_n10_p1967_Garcia |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
kynurenine tryptophan tryptophan 2,3 dioxygenase animal article chromatography enzymology liver male metabolism porphyria rat urine Animal Chromatography Kynurenine Liver Male Porphyria Rats Tryptophan Tryptophan Oxygenase |
| spellingShingle |
kynurenine tryptophan tryptophan 2,3 dioxygenase animal article chromatography enzymology liver male metabolism porphyria rat urine Animal Chromatography Kynurenine Liver Male Porphyria Rats Tryptophan Tryptophan Oxygenase Garcia, A.F. Grinstein, M. Tryptophan metabolism in experimental porphyria |
| topic_facet |
kynurenine tryptophan tryptophan 2,3 dioxygenase animal article chromatography enzymology liver male metabolism porphyria rat urine Animal Chromatography Kynurenine Liver Male Porphyria Rats Tryptophan Tryptophan Oxygenase |
| description |
Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptophan pyrrolase activity is diminished in porphyric animals. This is interpreted as being the result, at least in part, of a competitive inhibition between the porphyrins accumulated in the liver during the state of porphyria and the tryptophan pyrrolase heme coenzyme, for the tryptophan pyrrolase apoenzyme. © 1967. |
| format |
JOUR |
| author |
Garcia, A.F. Grinstein, M. |
| author_facet |
Garcia, A.F. Grinstein, M. |
| author_sort |
Garcia, A.F. |
| title |
Tryptophan metabolism in experimental porphyria |
| title_short |
Tryptophan metabolism in experimental porphyria |
| title_full |
Tryptophan metabolism in experimental porphyria |
| title_fullStr |
Tryptophan metabolism in experimental porphyria |
| title_full_unstemmed |
Tryptophan metabolism in experimental porphyria |
| title_sort |
tryptophan metabolism in experimental porphyria |
| url |
http://hdl.handle.net/20.500.12110/paper_00062952_v16_n10_p1967_Garcia |
| work_keys_str_mv |
AT garciaaf tryptophanmetabolisminexperimentalporphyria AT grinsteinm tryptophanmetabolisminexperimentalporphyria |
| _version_ |
1807318868779073536 |