Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate
Cyclic AMP inhibits growth rate of E. coli Hfr 3000. Doubling times in glucose minimal medium increased from 60 to about 90 minutes with the addition of 5 mM cAMP. This effect is specific since it was not observed when the cyclic nucleotide was replaced by 5′ AMP, ADP, ATP or adenosine. Half maximal...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0006291X_v52_n4_p1257_Judewicz |
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todo:paper_0006291X_v52_n4_p1257_Judewicz2023-10-03T14:04:05Z Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate Judewicz, N.D. De Robertis Jr., E.M. Torres, H.N. adenine nucleotide adenosine cyclic AMP galactosidase glucose glycerol malic acid derivative pyruvic acid derivative succinic acid derivative article chemical phenomena drug effect enzymology Escherichia coli growth, development and aging kinetics metabolism Adenine Nucleotides Adenosine Cyclic AMP Depression, Chemical Escherichia coli Galactosidases Glucose Glycerol Kinetics Malates Pyruvates Succinates Cyclic AMP inhibits growth rate of E. coli Hfr 3000. Doubling times in glucose minimal medium increased from 60 to about 90 minutes with the addition of 5 mM cAMP. This effect is specific since it was not observed when the cyclic nucleotide was replaced by 5′ AMP, ADP, ATP or adenosine. Half maximal inhibition was obtained with 1 to 3 mM cyclic AMP. This inhibition occurs only with those carbon sources which are known to decrease intracellular cyclic AMP levels, i.e. glucose and pyruvate. No inhibition was observed with succinate, malate or glycerol. © 1973. Fil:Judewicz, N.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De Robertis Jr., E.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Torres, H.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0006291X_v52_n4_p1257_Judewicz |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adenine nucleotide adenosine cyclic AMP galactosidase glucose glycerol malic acid derivative pyruvic acid derivative succinic acid derivative article chemical phenomena drug effect enzymology Escherichia coli growth, development and aging kinetics metabolism Adenine Nucleotides Adenosine Cyclic AMP Depression, Chemical Escherichia coli Galactosidases Glucose Glycerol Kinetics Malates Pyruvates Succinates |
| spellingShingle |
adenine nucleotide adenosine cyclic AMP galactosidase glucose glycerol malic acid derivative pyruvic acid derivative succinic acid derivative article chemical phenomena drug effect enzymology Escherichia coli growth, development and aging kinetics metabolism Adenine Nucleotides Adenosine Cyclic AMP Depression, Chemical Escherichia coli Galactosidases Glucose Glycerol Kinetics Malates Pyruvates Succinates Judewicz, N.D. De Robertis Jr., E.M. Torres, H.N. Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| topic_facet |
adenine nucleotide adenosine cyclic AMP galactosidase glucose glycerol malic acid derivative pyruvic acid derivative succinic acid derivative article chemical phenomena drug effect enzymology Escherichia coli growth, development and aging kinetics metabolism Adenine Nucleotides Adenosine Cyclic AMP Depression, Chemical Escherichia coli Galactosidases Glucose Glycerol Kinetics Malates Pyruvates Succinates |
| description |
Cyclic AMP inhibits growth rate of E. coli Hfr 3000. Doubling times in glucose minimal medium increased from 60 to about 90 minutes with the addition of 5 mM cAMP. This effect is specific since it was not observed when the cyclic nucleotide was replaced by 5′ AMP, ADP, ATP or adenosine. Half maximal inhibition was obtained with 1 to 3 mM cyclic AMP. This inhibition occurs only with those carbon sources which are known to decrease intracellular cyclic AMP levels, i.e. glucose and pyruvate. No inhibition was observed with succinate, malate or glycerol. © 1973. |
| format |
JOUR |
| author |
Judewicz, N.D. De Robertis Jr., E.M. Torres, H.N. |
| author_facet |
Judewicz, N.D. De Robertis Jr., E.M. Torres, H.N. |
| author_sort |
Judewicz, N.D. |
| title |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_short |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_full |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_fullStr |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_full_unstemmed |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_sort |
inhibition of escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| url |
http://hdl.handle.net/20.500.12110/paper_0006291X_v52_n4_p1257_Judewicz |
| work_keys_str_mv |
AT judewicznd inhibitionofescherichiacoligrowthbycyclicadenosine35monophosphate AT derobertisjrem inhibitionofescherichiacoligrowthbycyclicadenosine35monophosphate AT torreshn inhibitionofescherichiacoligrowthbycyclicadenosine35monophosphate |
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1807318029223067648 |