Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model
Objective: BNCT is a tumour cell targeted radiation therapy. Uniform targeting of heterogeneous tumours with therapeutically effective boron carriers would contribute to a therapeutic effect on all tumour cell populations and avoid radioresistant fractions. This remains an unresolved challenge. The...
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todo:paper_00039969_v51_n10_p922_Heber2023-10-03T13:57:09Z Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model Heber, E.M. Trivillin, V.A. Nigg, D.W. Itoiz, M.E. Gonzalez, B.N. Rebagliati, R.J. Batistoni, D. Kreimann, E.L. Schwint, A.E. BNCT Boron targeting Hamster cheek pouch Oral cancer 4 dihydroxyborylphenylalanine 4-dihydroxyborylphenylalanine 7,12 dimethylbenz[a]anthracene borane derivative boron derivative drug derivative phenylalanine animal article cheek chemically induced disorder disease model hamster metabolism methodology mouth mucosa mouth tumor neutron capture therapy precancer Syrian hamster 9,10-Dimethyl-1,2-benzanthracene Animals Borohydrides Boron Compounds Boron Neutron Capture Therapy Cheek Cricetinae Disease Models, Animal Mesocricetus Mouth Mucosa Mouth Neoplasms Phenylalanine Precancerous Conditions Cricetinae Objective: BNCT is a tumour cell targeted radiation therapy. Uniform targeting of heterogeneous tumours with therapeutically effective boron carriers would contribute to a therapeutic effect on all tumour cell populations and avoid radioresistant fractions. This remains an unresolved challenge. The aim of the present study was to evaluate the degree of variation in boron content delivered by boronophenylalanine (BPA), GB-10 (Na210B10H10) and the combined administration of (BPA + GB-10) in different portions of tumour, precancerous tissue around tumour and normal pouch tissue in the hamster cheek pouch oral cancer model. Materials and methods: Samples of different areas of tumour, precancerous tissue and normal pouch tissue were taken from tumour-bearing hamsters, 3 h post-administration of i.p. BPA (15.5 mg B/kg b.w.), or i.v. GB-10 (50 mg B/kg b.w.), or 3 h and 1.5 h post-administration respectively of i.v. GB-10 (34.5 mg B/b.w.) and sequential i.p. injections of BPA (total dose 31 mg B/kg b.w.) given jointly. Boron content was evaluated by inductively coupled plasma optical emission spectroscopy (ICP-OES). The degree of homogeneity in boron targeting was assessed in terms of the coefficient of variation (V: [S.D./mean] × 100) of boron values. Statistical analysis of the results was performed by one-way ANOVA and the least significant difference test. Results: GB-10 and GB-10 plus BPA achieved respectively a statistically significant 1.8- and 3.3-fold increase in targeting homogeneity over BPA. Conclusions: The combined boron compound administration protocol contributes to homogeneous targeting of heterogeneous tumours and would be expected to increase therapeutic efficacy of BNCT. © 2006 Elsevier Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00039969_v51_n10_p922_Heber |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
BNCT Boron targeting Hamster cheek pouch Oral cancer 4 dihydroxyborylphenylalanine 4-dihydroxyborylphenylalanine 7,12 dimethylbenz[a]anthracene borane derivative boron derivative drug derivative phenylalanine animal article cheek chemically induced disorder disease model hamster metabolism methodology mouth mucosa mouth tumor neutron capture therapy precancer Syrian hamster 9,10-Dimethyl-1,2-benzanthracene Animals Borohydrides Boron Compounds Boron Neutron Capture Therapy Cheek Cricetinae Disease Models, Animal Mesocricetus Mouth Mucosa Mouth Neoplasms Phenylalanine Precancerous Conditions Cricetinae |
| spellingShingle |
BNCT Boron targeting Hamster cheek pouch Oral cancer 4 dihydroxyborylphenylalanine 4-dihydroxyborylphenylalanine 7,12 dimethylbenz[a]anthracene borane derivative boron derivative drug derivative phenylalanine animal article cheek chemically induced disorder disease model hamster metabolism methodology mouth mucosa mouth tumor neutron capture therapy precancer Syrian hamster 9,10-Dimethyl-1,2-benzanthracene Animals Borohydrides Boron Compounds Boron Neutron Capture Therapy Cheek Cricetinae Disease Models, Animal Mesocricetus Mouth Mucosa Mouth Neoplasms Phenylalanine Precancerous Conditions Cricetinae Heber, E.M. Trivillin, V.A. Nigg, D.W. Itoiz, M.E. Gonzalez, B.N. Rebagliati, R.J. Batistoni, D. Kreimann, E.L. Schwint, A.E. Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model |
| topic_facet |
BNCT Boron targeting Hamster cheek pouch Oral cancer 4 dihydroxyborylphenylalanine 4-dihydroxyborylphenylalanine 7,12 dimethylbenz[a]anthracene borane derivative boron derivative drug derivative phenylalanine animal article cheek chemically induced disorder disease model hamster metabolism methodology mouth mucosa mouth tumor neutron capture therapy precancer Syrian hamster 9,10-Dimethyl-1,2-benzanthracene Animals Borohydrides Boron Compounds Boron Neutron Capture Therapy Cheek Cricetinae Disease Models, Animal Mesocricetus Mouth Mucosa Mouth Neoplasms Phenylalanine Precancerous Conditions Cricetinae |
| description |
Objective: BNCT is a tumour cell targeted radiation therapy. Uniform targeting of heterogeneous tumours with therapeutically effective boron carriers would contribute to a therapeutic effect on all tumour cell populations and avoid radioresistant fractions. This remains an unresolved challenge. The aim of the present study was to evaluate the degree of variation in boron content delivered by boronophenylalanine (BPA), GB-10 (Na210B10H10) and the combined administration of (BPA + GB-10) in different portions of tumour, precancerous tissue around tumour and normal pouch tissue in the hamster cheek pouch oral cancer model. Materials and methods: Samples of different areas of tumour, precancerous tissue and normal pouch tissue were taken from tumour-bearing hamsters, 3 h post-administration of i.p. BPA (15.5 mg B/kg b.w.), or i.v. GB-10 (50 mg B/kg b.w.), or 3 h and 1.5 h post-administration respectively of i.v. GB-10 (34.5 mg B/b.w.) and sequential i.p. injections of BPA (total dose 31 mg B/kg b.w.) given jointly. Boron content was evaluated by inductively coupled plasma optical emission spectroscopy (ICP-OES). The degree of homogeneity in boron targeting was assessed in terms of the coefficient of variation (V: [S.D./mean] × 100) of boron values. Statistical analysis of the results was performed by one-way ANOVA and the least significant difference test. Results: GB-10 and GB-10 plus BPA achieved respectively a statistically significant 1.8- and 3.3-fold increase in targeting homogeneity over BPA. Conclusions: The combined boron compound administration protocol contributes to homogeneous targeting of heterogeneous tumours and would be expected to increase therapeutic efficacy of BNCT. © 2006 Elsevier Ltd. All rights reserved. |
| format |
JOUR |
| author |
Heber, E.M. Trivillin, V.A. Nigg, D.W. Itoiz, M.E. Gonzalez, B.N. Rebagliati, R.J. Batistoni, D. Kreimann, E.L. Schwint, A.E. |
| author_facet |
Heber, E.M. Trivillin, V.A. Nigg, D.W. Itoiz, M.E. Gonzalez, B.N. Rebagliati, R.J. Batistoni, D. Kreimann, E.L. Schwint, A.E. |
| author_sort |
Heber, E.M. |
| title |
Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model |
| title_short |
Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model |
| title_full |
Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model |
| title_fullStr |
Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model |
| title_full_unstemmed |
Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model |
| title_sort |
homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (bnct): chemical analyses in the hamster cheek pouch oral cancer model |
| url |
http://hdl.handle.net/20.500.12110/paper_00039969_v51_n10_p922_Heber |
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