Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health
Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher pu...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00029637_v79_n5_p662_Newton |
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todo:paper_00029637_v79_n5_p662_Newton2023-10-03T13:55:02Z Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health Newton, P.N. Hampton, C.Y. Alter-Hall, K. Teerwarakulpana, T. Prakongpan, S. Ruangveerayuth, R. White, N.J. Day, N.P.J. Tudino, M.B. Mancuso, N. Fernández, F.M. acetylsalicylic acid alprenolol amitriptyline ampicillin antacid agent artemisinin ascorbic acid chloroquine chlorpheniramine diclofenac dipyrone doxycycline indometacin nicotinamide paracetamol prazepam prednisolone primaquine pyridoxine quinine sulfamethoxazole tetracycline thiamine tolperisone acidosis agranulocytosis article atomic absorption spectrometry bradycardia disease severity drowsiness drug capsule drug efficacy gastrointestinal irritation health care cost hemolysis human hypoglycemia malaria mass spectrometry methemoglobinemia morbidity mortality multidrug resistance Myanmar newborn hemolytic disease Plasmodium falciparum rash stomach irritation tablet Thailand tinnitus Plasmodium falciparum Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00029637_v79_n5_p662_Newton |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acetylsalicylic acid alprenolol amitriptyline ampicillin antacid agent artemisinin ascorbic acid chloroquine chlorpheniramine diclofenac dipyrone doxycycline indometacin nicotinamide paracetamol prazepam prednisolone primaquine pyridoxine quinine sulfamethoxazole tetracycline thiamine tolperisone acidosis agranulocytosis article atomic absorption spectrometry bradycardia disease severity drowsiness drug capsule drug efficacy gastrointestinal irritation health care cost hemolysis human hypoglycemia malaria mass spectrometry methemoglobinemia morbidity mortality multidrug resistance Myanmar newborn hemolytic disease Plasmodium falciparum rash stomach irritation tablet Thailand tinnitus Plasmodium falciparum |
| spellingShingle |
acetylsalicylic acid alprenolol amitriptyline ampicillin antacid agent artemisinin ascorbic acid chloroquine chlorpheniramine diclofenac dipyrone doxycycline indometacin nicotinamide paracetamol prazepam prednisolone primaquine pyridoxine quinine sulfamethoxazole tetracycline thiamine tolperisone acidosis agranulocytosis article atomic absorption spectrometry bradycardia disease severity drowsiness drug capsule drug efficacy gastrointestinal irritation health care cost hemolysis human hypoglycemia malaria mass spectrometry methemoglobinemia morbidity mortality multidrug resistance Myanmar newborn hemolytic disease Plasmodium falciparum rash stomach irritation tablet Thailand tinnitus Plasmodium falciparum Newton, P.N. Hampton, C.Y. Alter-Hall, K. Teerwarakulpana, T. Prakongpan, S. Ruangveerayuth, R. White, N.J. Day, N.P.J. Tudino, M.B. Mancuso, N. Fernández, F.M. Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health |
| topic_facet |
acetylsalicylic acid alprenolol amitriptyline ampicillin antacid agent artemisinin ascorbic acid chloroquine chlorpheniramine diclofenac dipyrone doxycycline indometacin nicotinamide paracetamol prazepam prednisolone primaquine pyridoxine quinine sulfamethoxazole tetracycline thiamine tolperisone acidosis agranulocytosis article atomic absorption spectrometry bradycardia disease severity drowsiness drug capsule drug efficacy gastrointestinal irritation health care cost hemolysis human hypoglycemia malaria mass spectrometry methemoglobinemia morbidity mortality multidrug resistance Myanmar newborn hemolytic disease Plasmodium falciparum rash stomach irritation tablet Thailand tinnitus Plasmodium falciparum |
| description |
Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene. |
| format |
JOUR |
| author |
Newton, P.N. Hampton, C.Y. Alter-Hall, K. Teerwarakulpana, T. Prakongpan, S. Ruangveerayuth, R. White, N.J. Day, N.P.J. Tudino, M.B. Mancuso, N. Fernández, F.M. |
| author_facet |
Newton, P.N. Hampton, C.Y. Alter-Hall, K. Teerwarakulpana, T. Prakongpan, S. Ruangveerayuth, R. White, N.J. Day, N.P.J. Tudino, M.B. Mancuso, N. Fernández, F.M. |
| author_sort |
Newton, P.N. |
| title |
Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health |
| title_short |
Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health |
| title_full |
Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health |
| title_fullStr |
Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health |
| title_full_unstemmed |
Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health |
| title_sort |
characterization of "yaa chud" medicine on the thailand-myanmar border: selecting for drug-resistant malaria and threatening public health |
| url |
http://hdl.handle.net/20.500.12110/paper_00029637_v79_n5_p662_Newton |
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