Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS
Trypanosoma cruzi lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, t...
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todo:paper_00029637_v78_n2_p294_Burgos2023-10-03T13:55:01Z Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS Burgos, J.M. Begher, S. Silva, H.M.V. Bisio, M. Duffy, T. Levin, M.J. Macedo, A.M. Schijman, A.G. parasite antibody cytochrome c oxidase microsatellite DNA protozoal DNA acquired immune deficiency syndrome adult allele article blood sampling case report central nervous system cerebrospinal fluid Chagas disease genetic polymorphism haplotype human male microsatellite marker mitochondrion nonhuman parasite identification Trypanosoma cruzi acquired immune deficiency syndrome AIDS related complex animal blood Bolivia central nervous system central nervous system infection Chagas disease fatality genetics isolation and purification parasitology physiology plant growth recurrent disease restriction fragment length polymorphism Trypanosoma cruzi Acquired Immunodeficiency Syndrome Adult AIDS-Related Opportunistic Infections Animals Bolivia Central Nervous System Central Nervous System Protozoal Infections Chagas Disease DNA, Protozoan Electron Transport Complex IV Fatal Outcome Humans Male Microsatellite Repeats Polymorphism, Genetic Polymorphism, Restriction Fragment Length Recurrence Tropism Trypanosoma cruzi Trypanosoma cruzi lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, the patient's blood was infected by a mixture of T. cruzi I and T. cruzi IId/e polyclonal populations while the cerebrospinal fluid showed only a monoclonal T. cruzi I population. Our findings do not corroborate the original assumption of innocuity for T. cruzi I in the southern cone of the Americas and highlight lineage I tropism for central nervous system causing lethal Chagas reactivation. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00029637_v78_n2_p294_Burgos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
parasite antibody cytochrome c oxidase microsatellite DNA protozoal DNA acquired immune deficiency syndrome adult allele article blood sampling case report central nervous system cerebrospinal fluid Chagas disease genetic polymorphism haplotype human male microsatellite marker mitochondrion nonhuman parasite identification Trypanosoma cruzi acquired immune deficiency syndrome AIDS related complex animal blood Bolivia central nervous system central nervous system infection Chagas disease fatality genetics isolation and purification parasitology physiology plant growth recurrent disease restriction fragment length polymorphism Trypanosoma cruzi Acquired Immunodeficiency Syndrome Adult AIDS-Related Opportunistic Infections Animals Bolivia Central Nervous System Central Nervous System Protozoal Infections Chagas Disease DNA, Protozoan Electron Transport Complex IV Fatal Outcome Humans Male Microsatellite Repeats Polymorphism, Genetic Polymorphism, Restriction Fragment Length Recurrence Tropism Trypanosoma cruzi |
| spellingShingle |
parasite antibody cytochrome c oxidase microsatellite DNA protozoal DNA acquired immune deficiency syndrome adult allele article blood sampling case report central nervous system cerebrospinal fluid Chagas disease genetic polymorphism haplotype human male microsatellite marker mitochondrion nonhuman parasite identification Trypanosoma cruzi acquired immune deficiency syndrome AIDS related complex animal blood Bolivia central nervous system central nervous system infection Chagas disease fatality genetics isolation and purification parasitology physiology plant growth recurrent disease restriction fragment length polymorphism Trypanosoma cruzi Acquired Immunodeficiency Syndrome Adult AIDS-Related Opportunistic Infections Animals Bolivia Central Nervous System Central Nervous System Protozoal Infections Chagas Disease DNA, Protozoan Electron Transport Complex IV Fatal Outcome Humans Male Microsatellite Repeats Polymorphism, Genetic Polymorphism, Restriction Fragment Length Recurrence Tropism Trypanosoma cruzi Burgos, J.M. Begher, S. Silva, H.M.V. Bisio, M. Duffy, T. Levin, M.J. Macedo, A.M. Schijman, A.G. Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS |
| topic_facet |
parasite antibody cytochrome c oxidase microsatellite DNA protozoal DNA acquired immune deficiency syndrome adult allele article blood sampling case report central nervous system cerebrospinal fluid Chagas disease genetic polymorphism haplotype human male microsatellite marker mitochondrion nonhuman parasite identification Trypanosoma cruzi acquired immune deficiency syndrome AIDS related complex animal blood Bolivia central nervous system central nervous system infection Chagas disease fatality genetics isolation and purification parasitology physiology plant growth recurrent disease restriction fragment length polymorphism Trypanosoma cruzi Acquired Immunodeficiency Syndrome Adult AIDS-Related Opportunistic Infections Animals Bolivia Central Nervous System Central Nervous System Protozoal Infections Chagas Disease DNA, Protozoan Electron Transport Complex IV Fatal Outcome Humans Male Microsatellite Repeats Polymorphism, Genetic Polymorphism, Restriction Fragment Length Recurrence Tropism Trypanosoma cruzi |
| description |
Trypanosoma cruzi lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, the patient's blood was infected by a mixture of T. cruzi I and T. cruzi IId/e polyclonal populations while the cerebrospinal fluid showed only a monoclonal T. cruzi I population. Our findings do not corroborate the original assumption of innocuity for T. cruzi I in the southern cone of the Americas and highlight lineage I tropism for central nervous system causing lethal Chagas reactivation. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene. |
| format |
JOUR |
| author |
Burgos, J.M. Begher, S. Silva, H.M.V. Bisio, M. Duffy, T. Levin, M.J. Macedo, A.M. Schijman, A.G. |
| author_facet |
Burgos, J.M. Begher, S. Silva, H.M.V. Bisio, M. Duffy, T. Levin, M.J. Macedo, A.M. Schijman, A.G. |
| author_sort |
Burgos, J.M. |
| title |
Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS |
| title_short |
Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS |
| title_full |
Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS |
| title_fullStr |
Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS |
| title_full_unstemmed |
Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS |
| title_sort |
case report: molecular identification of trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to aids |
| url |
http://hdl.handle.net/20.500.12110/paper_00029637_v78_n2_p294_Burgos |
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