Discrimination of nitroxyl and nitric oxide by water-soluble Mn(III) porphyrins

The water-soluble manganese(III) meso-tetrakis (N-ethylpyridinium-2-yl) porphyrin (MnIIITEPyP) and manganese(III) meso-(tetrakis(4-sulfonato- phenyl)) porphyrinate (MnIIITPPS) are able to chemically distinguish between HNO and NO donors, reacting with the former in a fast, efficient, and selective m...

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Detalles Bibliográficos
Autores principales: Martí, M.A., Bari, S.E., Estrin, D.A., Doctorovich, F.
Formato: JOUR
Materias:
Aromatic compounds
Catalysis
Decomposition
Manganese compounds
Organic acids
Organometallics
Probability density function
Reaction kinetics
Toluene
Catalytic decomposition
Discrimination
Donors
Porphyrins
manganese derivative
manganese meso[tetrakis(4 sulfonatophenyl)porphyrinate]
manganese mesotetrakis(n ethylpyridinium 2 yl)porphyrin
nitric oxide
oxygen
porphyrin derivative
reagent
sodium trioxodinitrate
toluene sulfohydroxamic acid
unclassified drug
water
aeration
anaerobic metabolism
aqueous solution
article
catalysis
chemical reaction kinetics
complex formation
density functional theory
solubility
Anaerobiosis
Hydroxamic Acids
Kinetics
Manganese
Metalloporphyrins
Nitric Oxide
Nitric Oxide Donors
Nitrites
Nitrogen Oxides
Oxidation-Reduction
Solubility
Water
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00027863_v127_n13_p4680_Marti
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The water-soluble manganese(III) meso-tetrakis (N-ethylpyridinium-2-yl) porphyrin (MnIIITEPyP) and manganese(III) meso-(tetrakis(4-sulfonato- phenyl)) porphyrinate (MnIIITPPS) are able to chemically distinguish between HNO and NO donors, reacting with the former in a fast, efficient, and selective manner with concomitant formation of the {MnNO}7 complex (kon(HNO) ≈ 105 M-1 s-1), while they are inert or react very slowly with NO donors. DFT calculations and kinetic data suggest that HNO trapping is operative at least in the case of Mn IIITPPS, while catalytic decomposition of the HNO donors (sodium trioxodinitrate and toluene sulfohydroxamic acid) seems to be the main pathway for MnIIITEPyP. In the presence of oxygen, the product Mn IITEPyP(NO) oxidizes back to MnIIITEPyP, making it possible to process large ratios of nitroxyl donor with small amounts of porphyrin. © 2005 American Chemical Society.

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