A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage

A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule i...

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Detalles Bibliográficos
Autores principales: Zayat, L., Calero, C., Alborés, P., Baraldo, L., Etchenique, R.
Formato: JOUR
Materias:
4 aminopyridine
ligand
metal complex
ruthenium complex
xenon
action potential
animal cell
animal experiment
animal model
article
cell activity
controlled study
covalent bond
crystallization
diode
leech
light absorption
membrane permeability
membrane potential
nerve cell
neurochemistry
nonhuman
nuclear magnetic resonance spectroscopy
oxidation reduction potential
photoactivation
photochemistry
quantum yield
synthesis
2,2'-Dipyridyl
4-Aminopyridine
Action Potentials
Animals
Drug Carriers
Ganglia
Leeches
Membrane Potentials
Neurons
Organometallic Compounds
Oxidation-Reduction
Photochemistry
Potassium Channel Blockers
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00027863_v125_n4_p882_Zayat
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed. Copyright © 2003 American Chemical Society.

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