A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage

A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule i...

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Autores principales:	Zayat, L., Calero, C., Alborés, P., Baraldo, L., Etchenique, R.
Formato:	JOUR
Materias:	4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00027863_v125_n4_p882_Zayat
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00027863_v125_n4_p882_Zayat
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spelling	todo:paper_00027863_v125_n4_p882_Zayat2023-10-03T13:53:34Z A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage Zayat, L. Calero, C. Alborés, P. Baraldo, L. Etchenique, R. 4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed. Copyright © 2003 American Chemical Society. Fil:Zayat, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Calero, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alborés, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Baraldo, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00027863_v125_n4_p882_Zayat
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers
spellingShingle	4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers Zayat, L. Calero, C. Alborés, P. Baraldo, L. Etchenique, R. A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
topic_facet	4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers
description	A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed. Copyright © 2003 American Chemical Society.
format	JOUR
author	Zayat, L. Calero, C. Alborés, P. Baraldo, L. Etchenique, R.
author_facet	Zayat, L. Calero, C. Alborés, P. Baraldo, L. Etchenique, R.
author_sort	Zayat, L.
title	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_short	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_full	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_fullStr	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_full_unstemmed	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_sort	new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage
url	http://hdl.handle.net/20.500.12110/paper_00027863_v125_n4_p882_Zayat
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A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage

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