A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness

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Fil: Bei, Jinlong. Guangdong Academy of Agricultural Sciences (GDAAS). AGRO-Biological Gene Research Center, Guangzhou, China.

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Autores principales: Bei, Jinlong, Bigi, María Mercedes, Zhang, Qi, Blanco, Federico Carlos, López, Beatríz, Sasiain, María del Carmen, Soria, Marcelo Abel, Bigi, Fabiana
Formato: article Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2020
Materias:
MYCOBACTERIUM TUBERCULOSIS
PHENOTYPIC CHARACTERIZATION
EPIDEMIOLOGICAL
Acceso en línea:http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2021beijinlong
Aporte de:
FAUBA Digital - Facultad de Agronomía (UBA) de Universidad de Buenos Aires
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spelling snrd:2021beijinlong2023-02-10T10:19:05Z Bei, Jinlong Bigi, María Mercedes Zhang, Qi Blanco, Federico Carlos López, Beatríz Sasiain, María del Carmen Soria, Marcelo Abel Bigi, Fabiana 2020 Fil: Bei, Jinlong. Guangdong Academy of Agricultural Sciences (GDAAS). AGRO-Biological Gene Research Center, Guangzhou, China. Fil: Bigi, María Mercedes. Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina. Fil: Zhang, Qi. Guangdong Academy of Agricultural Sciences (GDAAS). AGRO-Biological Gene Research Center, Guangzhou, China. Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. - CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. Fil: López, Beatríz. Instituto Nacional de Enfermedades Infecciosas - ANLIS Carlos Malbrán. Buenos Aires, Argentina. Fil: Sasiain, María del Carmen. Academia Nacional de Medicina (IMEX). Buenos Aires, Argentina. - CONICET - Academia Nacional de Medicina (IMEX). Buenos Aires, Argentina. Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina. Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. - CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB (MDR-TB) outbreak in Buenos Aires. This outbreak started in the early 1990s and in the mid 2000s still accounted for 29% of all MDR-TB cases in Argentina. By contrast, a clonal variant of strain M, named 410, has caused a single tuberculosis case since the onset of the outbreak. The molecular bases of the high epidemiological fitness of the M strain remain unclear. To assess its unique molecular properties, herein, we performed a comparative protein and lipid analysis of a representative clone of the M strain (Mp) and the nonprosperous M variant 410. We also evaluated their growth in low pH. The variant 410 had higher levels of latency proteins under standard conditions and delayed growth at low pH, suggesting that it is more sensitive to stress stimuli than Mp. Moreover, Mp showed higher levels of mycolic acids covalently attached to the cell wall and lower accumulation of free mycolic acids in the outer layer than the 410 strain. The low expression of latency proteins together with the reduced content of surface mycolic acids may facilitate Mp to evade the host immune responses. grafs., fot. application/pdf 10.1155/2020/4741237 2314-6141 http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2021beijinlong eng info:eu-repo/semantics/openAccess openAccess BioMed research international Vol.20 art.4741237, 9 p. https://www.hindawi.com/ MYCOBACTERIUM TUBERCULOSIS PHENOTYPIC CHARACTERIZATION EPIDEMIOLOGICAL A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness article info:eu-repo/semantics/article info:ar-repo/semantics/artículo publishedVersion info:eu-repo/semantics/publishedVersion
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-140
collection FAUBA Digital - Facultad de Agronomía (UBA)
language Inglés
orig_language_str_mv eng
topic MYCOBACTERIUM TUBERCULOSIS
PHENOTYPIC CHARACTERIZATION
EPIDEMIOLOGICAL
spellingShingle MYCOBACTERIUM TUBERCULOSIS
PHENOTYPIC CHARACTERIZATION
EPIDEMIOLOGICAL
Bei, Jinlong
Bigi, María Mercedes
Zhang, Qi
Blanco, Federico Carlos
López, Beatríz
Sasiain, María del Carmen
Soria, Marcelo Abel
Bigi, Fabiana
A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness
topic_facet MYCOBACTERIUM TUBERCULOSIS
PHENOTYPIC CHARACTERIZATION
EPIDEMIOLOGICAL
description Fil: Bei, Jinlong. Guangdong Academy of Agricultural Sciences (GDAAS). AGRO-Biological Gene Research Center, Guangzhou, China.
format article
Artículo
Artículo
publishedVersion
publishedVersion
author Bei, Jinlong
Bigi, María Mercedes
Zhang, Qi
Blanco, Federico Carlos
López, Beatríz
Sasiain, María del Carmen
Soria, Marcelo Abel
Bigi, Fabiana
author_facet Bei, Jinlong
Bigi, María Mercedes
Zhang, Qi
Blanco, Federico Carlos
López, Beatríz
Sasiain, María del Carmen
Soria, Marcelo Abel
Bigi, Fabiana
author_sort Bei, Jinlong
title A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness
title_short A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness
title_full A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness
title_fullStr A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness
title_full_unstemmed A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness
title_sort phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of mycobacterium tuberculosis with opposite epidemiological fitness
publishDate 2020
url http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2021beijinlong
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