Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress

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Fil: Forrellad, Marina A. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina.

Detalles Bibliográficos
Autores principales: Forrellad, Marina A., Vázquez, Cristina L., Blanco, Federico C., Klepp, Laura Inés, García, Elizabeth A., Rocha, Rosana V., Villafañe, Luciana, Bigi, María Mercedes
Formato: article Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2019
Materias:
MYCOBACTERIUM TUBERCULOSIS
OXIDATIVE STRESS
VIRULENCE FACTOR
RV2617C
ERP
Acceso en línea:http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2019forrellad
Aporte de:
FAUBA Digital - Facultad de Agronomía (UBA) de Universidad de Buenos Aires
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spelling snrd:2019forrellad2021-10-15T16:56:07Z Forrellad, Marina A. Vázquez, Cristina L. Blanco, Federico C. Klepp, Laura Inés García, Elizabeth A. Rocha, Rosana V. Villafañe, Luciana Bigi, María Mercedes 2019 Fil: Forrellad, Marina A. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. Fil: Vázquez, Cristina L. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. Fil: Blanco, Federico C. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. Fil: Klepp, Laura Inés. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. Fil: García, Elizabeth A. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. Fil: Rocha, Rosana V. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. Fil: Villafañe, Luciana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. Fil: Bigi, María Mercedes. Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina. In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this protein interacts with the virulence factor P36 (also named Erp) and KdpF, a protein linked to nitrosative stress. Here, we showed that knockout of the Rv2617c gene in M. tuberculosis CDC1551 reduced the replication of the pathogen in a mouse model of infection and favored the trafficking of mycobacteria to phagolysosomes. We also demonstrated that Rv2617c and P36 are required for resistance to in vitro hydrogen peroxide treatment in M. tuberculosis and Mycobacterium bovis, respectively. These findings indicate Rv2617c and P36 act in concert to prevent bacterial damage upon oxidative stress. grafs., fot. application/pdf doi:10.1080/21505594.2019.1693714 issn:2150-5608 http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2019forrellad eng info:eu-repo/semantics/openAccess openAccess http://ri.agro.uba.ar/greenstone3/library/page/biblioteca#section4 Virulence Vol.10, no.1 1026–1033 https://taylorandfrancis.com MYCOBACTERIUM TUBERCULOSIS OXIDATIVE STRESS VIRULENCE FACTOR MYCOBACTERIUM TUBERCULOSIS RV2617C ERP Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress article info:eu-repo/semantics/article info:ar-repo/semantics/artículo publishedVersion info:eu-repo/semantics/publishedVersion
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-140
collection FAUBA Digital - Facultad de Agronomía (UBA)
language Inglés
orig_language_str_mv eng
topic MYCOBACTERIUM TUBERCULOSIS
OXIDATIVE STRESS
VIRULENCE FACTOR
MYCOBACTERIUM TUBERCULOSIS
RV2617C
ERP
spellingShingle MYCOBACTERIUM TUBERCULOSIS
OXIDATIVE STRESS
VIRULENCE FACTOR
MYCOBACTERIUM TUBERCULOSIS
RV2617C
ERP
Forrellad, Marina A.
Vázquez, Cristina L.
Blanco, Federico C.
Klepp, Laura Inés
García, Elizabeth A.
Rocha, Rosana V.
Villafañe, Luciana
Bigi, María Mercedes
Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
topic_facet MYCOBACTERIUM TUBERCULOSIS
OXIDATIVE STRESS
VIRULENCE FACTOR
MYCOBACTERIUM TUBERCULOSIS
RV2617C
ERP
description Fil: Forrellad, Marina A. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina.
format article
Artículo
Artículo
publishedVersion
publishedVersion
author Forrellad, Marina A.
Vázquez, Cristina L.
Blanco, Federico C.
Klepp, Laura Inés
García, Elizabeth A.
Rocha, Rosana V.
Villafañe, Luciana
Bigi, María Mercedes
author_facet Forrellad, Marina A.
Vázquez, Cristina L.
Blanco, Federico C.
Klepp, Laura Inés
García, Elizabeth A.
Rocha, Rosana V.
Villafañe, Luciana
Bigi, María Mercedes
author_sort Forrellad, Marina A.
title Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
title_short Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
title_full Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
title_fullStr Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
title_full_unstemmed Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
title_sort rv2617c and p36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
publishDate 2019
url http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2019forrellad
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