Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from laminaria saccharina brown seaweed

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Sulfated polysaccharides from Laminaria saccharina (new name: Saccharina latissima) brown seaweed show promising activity for the treatment of inflammation, thrombosis, and cancer; yet the molecular mechanisms underlying these properties remain poorly understood. The aim of this work was to characte...

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Detalles Bibliográficos
Autores principales: Croci, D.O., Cumashi, A., Ushakova, N.A., Preobrazhenskaya, M.E., Piccoli, A., Totani, L., Ustyuzhanina, N.E., Bilan, M.I., Usov, A.I., Grachev, A.A., Morozevich, G.E., Berman, A.E., Sanderson, C.J., Kelly, M., Gregorio, P., Rossi, C., Tinari, N., Iacobelli, S., Rabinovich, G.A., Nifantiev, N.E.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2011
Materias:
bovine serum albumin
carbohydrate derivative
fibroblast growth factor
hemoglobin
o sulfated mannoglucuronofucan derivative
plasminogen activator inhibitor 1
polysaccharide sulfate
sulfated fucan derivative
unclassified drug
angiogenesis inhibitor
anticoagulant agent
antiinflammatory agent
biological product
fucoidin
fucose
polysaccharide
angiogenesis
animal experiment
animal model
antiangiogenic activity
anticoagulation
antiinflammatory activity
antineoplastic activity
article
biological activity
breast cancer
cancer growth
cancer inhibition
cell level
cell surface
controlled study
drug determination
drug efficacy
drug isolation
drug structure
endothelium cell
fibroblast
human
human cell
in vitro study
in vivo study
Laminaria
Laminaria saccharina
leukocyte migration inhibition
melanoma
melanoma cell
mouse
nonhuman
partial thromboplastin time
peritonitis
rat
thrombocyte adhesion
tumor vascularization
animal
brown alga
C57BL mouse
cell culture
chemistry
drug effect
evaluation
female
inflammation
metabolism
pathology
physiology
seaweed
Wistar rat
Bovinae
Mus
Rattus
Saccharina latissima
Angiogenesis Inhibitors
Animals
Anti-Inflammatory Agents
Anticoagulants
Biological Products
Cells, Cultured
Endothelial Cells
Female
Fucose
Humans
Inflammation
Mice
Mice, Inbred C57BL
Neovascularization, Physiologic
Phaeophyta
Polysaccharides
Rats
Rats, Wistar
Seaweed
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v6_n2_p_Croci
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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