Intra-cluster percolation of calcium signals
Calcium signals are involved in a large variety of physiological processes. Their versatility relies on the diversity of spatiotemporal behaviors that the calcium concentration can display. Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R's) is a key component that parti...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | Artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
2010
|
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19326203_v5_n2_p_Solovey |
| Aporte de: |
| id |
paperaa:paper_19326203_v5_n2_p_Solovey |
|---|---|
| record_format |
dspace |
| spelling |
paperaa:paper_19326203_v5_n2_p_Solovey2023-06-12T16:51:26Z Intra-cluster percolation of calcium signals PLoS ONE 2010;5(2) Solovey, G. Dawson, S.P. calcium channel calcium ion inositol 1,4,5 trisphosphate receptor calcium calcium channel inositol 1,4,5 trisphosphate inositol 1,4,5 trisphosphate receptor article binding competition calcium signaling cluster analysis molecular interaction Poisson distribution protein analysis protein protein interaction statistical analysis stochastic model algorithm animal biological model human metabolism physiology statistics Neptunia Algorithms Animals Calcium Calcium Channels Calcium Signaling Humans Inositol 1,4,5-Trisphosphate Inositol 1,4,5-Trisphosphate Receptors Models, Biological Stochastic Processes Calcium signals are involved in a large variety of physiological processes. Their versatility relies on the diversity of spatiotemporal behaviors that the calcium concentration can display. Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R's) is a key component that participates in both local signals such as "puffs" and in global waves. IP3R's are usually organized in clusters on the membrane of the endoplasmic reticulum and their spatial distribution has important effects on the resulting signal. Recent high resolution observations [1] of Ca2+ puffs offer a window to study intra-cluster organization. The experiments give the distribution of the number of IP3R's that open during each puff without much processing. Here we present a simple model with which we interpret the experimental distribution in terms of two stochastic processes: IP3 binding and unbinding and Ca2+-mediated inter-channel coupling. Depending on the parameters of the system, the distribution may be dominated by one or the other process. The transition between both extreme cases is similar to a percolation process. We show how, from an analysis of the experimental distribution, information can be obtained on the relative weight of the two processes. The largest distance over which Ca2+mediated coupling acts and the density of IP3-bound IP3R's of the cluster can also be estimated. The approach allows us to infer properties of the interactions among the channels of the cluster from statistical information on their emergent collective behavior. © 2010 Solovey, Dawson. Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19326203_v5_n2_p_Solovey |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
calcium channel calcium ion inositol 1,4,5 trisphosphate receptor calcium calcium channel inositol 1,4,5 trisphosphate inositol 1,4,5 trisphosphate receptor article binding competition calcium signaling cluster analysis molecular interaction Poisson distribution protein analysis protein protein interaction statistical analysis stochastic model algorithm animal biological model human metabolism physiology statistics Neptunia Algorithms Animals Calcium Calcium Channels Calcium Signaling Humans Inositol 1,4,5-Trisphosphate Inositol 1,4,5-Trisphosphate Receptors Models, Biological Stochastic Processes |
| spellingShingle |
calcium channel calcium ion inositol 1,4,5 trisphosphate receptor calcium calcium channel inositol 1,4,5 trisphosphate inositol 1,4,5 trisphosphate receptor article binding competition calcium signaling cluster analysis molecular interaction Poisson distribution protein analysis protein protein interaction statistical analysis stochastic model algorithm animal biological model human metabolism physiology statistics Neptunia Algorithms Animals Calcium Calcium Channels Calcium Signaling Humans Inositol 1,4,5-Trisphosphate Inositol 1,4,5-Trisphosphate Receptors Models, Biological Stochastic Processes Solovey, G. Dawson, S.P. Intra-cluster percolation of calcium signals |
| topic_facet |
calcium channel calcium ion inositol 1,4,5 trisphosphate receptor calcium calcium channel inositol 1,4,5 trisphosphate inositol 1,4,5 trisphosphate receptor article binding competition calcium signaling cluster analysis molecular interaction Poisson distribution protein analysis protein protein interaction statistical analysis stochastic model algorithm animal biological model human metabolism physiology statistics Neptunia Algorithms Animals Calcium Calcium Channels Calcium Signaling Humans Inositol 1,4,5-Trisphosphate Inositol 1,4,5-Trisphosphate Receptors Models, Biological Stochastic Processes |
| description |
Calcium signals are involved in a large variety of physiological processes. Their versatility relies on the diversity of spatiotemporal behaviors that the calcium concentration can display. Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R's) is a key component that participates in both local signals such as "puffs" and in global waves. IP3R's are usually organized in clusters on the membrane of the endoplasmic reticulum and their spatial distribution has important effects on the resulting signal. Recent high resolution observations [1] of Ca2+ puffs offer a window to study intra-cluster organization. The experiments give the distribution of the number of IP3R's that open during each puff without much processing. Here we present a simple model with which we interpret the experimental distribution in terms of two stochastic processes: IP3 binding and unbinding and Ca2+-mediated inter-channel coupling. Depending on the parameters of the system, the distribution may be dominated by one or the other process. The transition between both extreme cases is similar to a percolation process. We show how, from an analysis of the experimental distribution, information can be obtained on the relative weight of the two processes. The largest distance over which Ca2+mediated coupling acts and the density of IP3-bound IP3R's of the cluster can also be estimated. The approach allows us to infer properties of the interactions among the channels of the cluster from statistical information on their emergent collective behavior. © 2010 Solovey, Dawson. |
| format |
Artículo Artículo publishedVersion |
| author |
Solovey, G. Dawson, S.P. |
| author_facet |
Solovey, G. Dawson, S.P. |
| author_sort |
Solovey, G. |
| title |
Intra-cluster percolation of calcium signals |
| title_short |
Intra-cluster percolation of calcium signals |
| title_full |
Intra-cluster percolation of calcium signals |
| title_fullStr |
Intra-cluster percolation of calcium signals |
| title_full_unstemmed |
Intra-cluster percolation of calcium signals |
| title_sort |
intra-cluster percolation of calcium signals |
| publishDate |
2010 |
| url |
http://hdl.handle.net/20.500.12110/paper_19326203_v5_n2_p_Solovey |
| work_keys_str_mv |
AT soloveyg intraclusterpercolationofcalciumsignals AT dawsonsp intraclusterpercolationofcalciumsignals |
| _version_ |
1769810353875582976 |