Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice

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Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the...

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Autores principales:	Kelly, M.A., Low, M.J., Rubinstein, M., Phillips, T.J.
Formato:	Artículo publishedVersion
Lenguaje:	Inglés
Publicado:	2008
Materias:	Dopamine receptors Knockout Locomotor activity Neuroadaptation Null mutant Psychostimulant Sensitization 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate dopamine 1 receptor dopamine 2 receptor methamphetamine animal behavior animal experiment article controlled study drug response locomotion mouse nonhuman priority journal sensitization Amphetamine-Related Disorders Animals Benzazepines Central Nervous System Stimulants Dopamine Antagonists Female Hyperkinesis Male Methamphetamine Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Receptors, Dopamine D1 Receptors, Dopamine D2 Animalia Mus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_16011848_v7_n5_p568_Kelly
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paperaa:paper_16011848_v7_n5_p568_Kelly2023-06-12T16:50:51Z Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice Genes Brain Behav. 2008;7(5):568-577 Kelly, M.A. Low, M.J. Rubinstein, M. Phillips, T.J. Dopamine receptors Knockout Locomotor activity Neuroadaptation Null mutant Psychostimulant Sensitization 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate dopamine 1 receptor dopamine 2 receptor methamphetamine animal behavior animal experiment article controlled study drug response locomotion mouse nonhuman priority journal sensitization Amphetamine-Related Disorders Animals Benzazepines Central Nervous System Stimulants Dopamine Antagonists Female Hyperkinesis Male Methamphetamine Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Receptors, Dopamine D1 Receptors, Dopamine D2 Animalia Mus Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the combination of dopamine D2 receptor-deficient mice and a D1-like antagonist to examine dopamine D1 and D2 receptor involvement in acute and sensitized locomotor responses to methamphetamine. Absence of the dopamine D2 receptor resulted in attenuation of the acute stimulant effects of methamphetamine. Mutant and wild-type mice exhibited sensitization that lasted longer within the time period of the challenge test in the mutant animals. Pretreatment with the D1-like receptor antagonist SCH 23390 produced more potent reductions in the acute and sensitized locomotor responses to methamphetamine in D2 receptor-deficient mice than in wild-type mice; however, the expression of locomotor sensitization when challenged with methamphetamine alone was equivalently attenuated by previous treatment with SCH 23390. These data suggest that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1-like receptors to influence the acquisition of methamphetamine-induced behavioral sensitization, traits that may influence continued methamphetamine use. Fil:Rubinstein, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16011848_v7_n5_p568_Kelly
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language	Inglés
orig_language_str_mv	eng
topic	Dopamine receptors Knockout Locomotor activity Neuroadaptation Null mutant Psychostimulant Sensitization 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate dopamine 1 receptor dopamine 2 receptor methamphetamine animal behavior animal experiment article controlled study drug response locomotion mouse nonhuman priority journal sensitization Amphetamine-Related Disorders Animals Benzazepines Central Nervous System Stimulants Dopamine Antagonists Female Hyperkinesis Male Methamphetamine Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Receptors, Dopamine D1 Receptors, Dopamine D2 Animalia Mus
spellingShingle	Dopamine receptors Knockout Locomotor activity Neuroadaptation Null mutant Psychostimulant Sensitization 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate dopamine 1 receptor dopamine 2 receptor methamphetamine animal behavior animal experiment article controlled study drug response locomotion mouse nonhuman priority journal sensitization Amphetamine-Related Disorders Animals Benzazepines Central Nervous System Stimulants Dopamine Antagonists Female Hyperkinesis Male Methamphetamine Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Receptors, Dopamine D1 Receptors, Dopamine D2 Animalia Mus Kelly, M.A. Low, M.J. Rubinstein, M. Phillips, T.J. Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
topic_facet	Dopamine receptors Knockout Locomotor activity Neuroadaptation Null mutant Psychostimulant Sensitization 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate dopamine 1 receptor dopamine 2 receptor methamphetamine animal behavior animal experiment article controlled study drug response locomotion mouse nonhuman priority journal sensitization Amphetamine-Related Disorders Animals Benzazepines Central Nervous System Stimulants Dopamine Antagonists Female Hyperkinesis Male Methamphetamine Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Receptors, Dopamine D1 Receptors, Dopamine D2 Animalia Mus
description	Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the combination of dopamine D2 receptor-deficient mice and a D1-like antagonist to examine dopamine D1 and D2 receptor involvement in acute and sensitized locomotor responses to methamphetamine. Absence of the dopamine D2 receptor resulted in attenuation of the acute stimulant effects of methamphetamine. Mutant and wild-type mice exhibited sensitization that lasted longer within the time period of the challenge test in the mutant animals. Pretreatment with the D1-like receptor antagonist SCH 23390 produced more potent reductions in the acute and sensitized locomotor responses to methamphetamine in D2 receptor-deficient mice than in wild-type mice; however, the expression of locomotor sensitization when challenged with methamphetamine alone was equivalently attenuated by previous treatment with SCH 23390. These data suggest that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1-like receptors to influence the acquisition of methamphetamine-induced behavioral sensitization, traits that may influence continued methamphetamine use.
format	Artículo Artículo publishedVersion
author	Kelly, M.A. Low, M.J. Rubinstein, M. Phillips, T.J.
author_facet	Kelly, M.A. Low, M.J. Rubinstein, M. Phillips, T.J.
author_sort	Kelly, M.A.
title	Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_short	Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_full	Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_fullStr	Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_full_unstemmed	Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_sort	role of dopamine d1-like receptors in methamphetamine locomotor responses of d2 receptor knockout mice
publishDate	2008
url	http://hdl.handle.net/20.500.12110/paper_16011848_v7_n5_p568_Kelly
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Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice

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