Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings

Mostrar todas las versiones(3)

Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified in a wide variety of cells and tissues. Through recognition of cell surface glycoproteins and glycolipids, these endogenous lectins can trigg...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Laderach, D.J., Compagno, D., Toscano, M.A., Croci, D.O., Dergan-Dylon, S., Salatino, M., Rabinovich, G.A.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2010
Materias:
Apoptosis
Differentiation
Galectins
Immune regulation
Oncogenesis
Signaling pathways
galaptin
galectin
glycan
polysaccharide
cell adhesion
cell differentiation
cell proliferation
cell transformation
connective tissue
embryo development
hematopoietic system
nervous tissue
protein expression
protein function
protein interaction
review
signal transduction
tumor cell
animal
hematopoiesis
human
metabolism
neoplasm
pathophysiology
physiology
Animalia
Animals
Hematopoiesis
Humans
Neoplasms
Polysaccharides
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15216543_v62_n1_p1_Laderach
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paperaa:paper_15216543_v62_n1_p1_Laderach
record_format dspace
spelling paperaa:paper_15216543_v62_n1_p1_Laderach2023-06-12T16:50:35Z Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings IUBMB Life 2010;62(1):1-13 Laderach, D.J. Compagno, D. Toscano, M.A. Croci, D.O. Dergan-Dylon, S. Salatino, M. Rabinovich, G.A. Apoptosis Differentiation Galectins Immune regulation Oncogenesis Signaling pathways galaptin galectin glycan galectin polysaccharide cell adhesion cell differentiation cell proliferation cell transformation connective tissue embryo development hematopoietic system nervous tissue protein expression protein function protein interaction review signal transduction tumor cell animal hematopoiesis human metabolism neoplasm pathophysiology physiology signal transduction Animalia Animals Galectins Hematopoiesis Humans Neoplasms Polysaccharides Signal Transduction Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified in a wide variety of cells and tissues. Through recognition of cell surface glycoproteins and glycolipids, these endogenous lectins can trigger a cascade of intracellular signaling pathways capable of modulating cell differentiation, proliferation, survival, and migration. These cellular events are critical in a variety of biological processes including embryogenesis, angiogenesis, neurogenesis, and immunity and are substantially altered during tumorigenesis, neurodegeneration, and inflammation. In addition, galectins can modulate intracellular functions and this effect involves direct interactions with distinct signaling pathways. In this review, we discuss current knowledge on the intracellular signaling pathways triggered by this multifunctional family of β-galactoside-binding proteins in selected physiological and pathological settings. Understanding the "galectin signalosome" will be essential to delineate rational therapeutic strategies based on the specific control of galectin expression and function. © 2009 IUBMB. Fil:Toscano, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Salatino, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15216543_v62_n1_p1_Laderach
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Inglés
orig_language_str_mv eng
topic Apoptosis
Differentiation
Galectins
Immune regulation
Oncogenesis
Signaling pathways
galaptin
galectin
glycan
galectin
polysaccharide
cell adhesion
cell differentiation
cell proliferation
cell transformation
connective tissue
embryo development
hematopoietic system
nervous tissue
protein expression
protein function
protein interaction
review
signal transduction
tumor cell
animal
hematopoiesis
human
metabolism
neoplasm
pathophysiology
physiology
signal transduction
Animalia
Animals
Galectins
Hematopoiesis
Humans
Neoplasms
Polysaccharides
Signal Transduction
spellingShingle Apoptosis
Differentiation
Galectins
Immune regulation
Oncogenesis
Signaling pathways
galaptin
galectin
glycan
galectin
polysaccharide
cell adhesion
cell differentiation
cell proliferation
cell transformation
connective tissue
embryo development
hematopoietic system
nervous tissue
protein expression
protein function
protein interaction
review
signal transduction
tumor cell
animal
hematopoiesis
human
metabolism
neoplasm
pathophysiology
physiology
signal transduction
Animalia
Animals
Galectins
Hematopoiesis
Humans
Neoplasms
Polysaccharides
Signal Transduction
Laderach, D.J.
Compagno, D.
Toscano, M.A.
Croci, D.O.
Dergan-Dylon, S.
Salatino, M.
Rabinovich, G.A.
Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
topic_facet Apoptosis
Differentiation
Galectins
Immune regulation
Oncogenesis
Signaling pathways
galaptin
galectin
glycan
galectin
polysaccharide
cell adhesion
cell differentiation
cell proliferation
cell transformation
connective tissue
embryo development
hematopoietic system
nervous tissue
protein expression
protein function
protein interaction
review
signal transduction
tumor cell
animal
hematopoiesis
human
metabolism
neoplasm
pathophysiology
physiology
signal transduction
Animalia
Animals
Galectins
Hematopoiesis
Humans
Neoplasms
Polysaccharides
Signal Transduction
description Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified in a wide variety of cells and tissues. Through recognition of cell surface glycoproteins and glycolipids, these endogenous lectins can trigger a cascade of intracellular signaling pathways capable of modulating cell differentiation, proliferation, survival, and migration. These cellular events are critical in a variety of biological processes including embryogenesis, angiogenesis, neurogenesis, and immunity and are substantially altered during tumorigenesis, neurodegeneration, and inflammation. In addition, galectins can modulate intracellular functions and this effect involves direct interactions with distinct signaling pathways. In this review, we discuss current knowledge on the intracellular signaling pathways triggered by this multifunctional family of β-galactoside-binding proteins in selected physiological and pathological settings. Understanding the "galectin signalosome" will be essential to delineate rational therapeutic strategies based on the specific control of galectin expression and function. © 2009 IUBMB.
format Artículo
Artículo
publishedVersion
author Laderach, D.J.
Compagno, D.
Toscano, M.A.
Croci, D.O.
Dergan-Dylon, S.
Salatino, M.
Rabinovich, G.A.
author_facet Laderach, D.J.
Compagno, D.
Toscano, M.A.
Croci, D.O.
Dergan-Dylon, S.
Salatino, M.
Rabinovich, G.A.
author_sort Laderach, D.J.
title Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
title_short Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
title_full Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
title_fullStr Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
title_full_unstemmed Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
title_sort dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
publishDate 2010
url http://hdl.handle.net/20.500.12110/paper_15216543_v62_n1_p1_Laderach
work_keys_str_mv AT laderachdj dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings
AT compagnod dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings
AT toscanoma dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings
AT crocido dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings
AT dergandylons dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings
AT salatinom dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings
AT rabinovichga dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings
_version_ 1769810140269117440

Ejemplares similares