Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better

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The realization that the mammalian proteomic complexity is achieved with a limited number of genes demands a better understanding of alternative splicing regulation. Promoter control of alternative splicing was originally described by our group in studies performed on the fibronectin gene. Recently,...

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Detalles Bibliográficos
Autores principales: Nogués, G., Kadener, S., Cramer, P., De la Mata, M., Fededa, J.P., Blaustein, M., Srebrow, A., Kornblihtt, A.R.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2003
Materias:
Alternative splicing
Elongation
mRNA processing
RNA polymerase II
Transcription
calcitonin gene related peptide
fibronectin
Hermes antigen
messenger RNA
protein
proteome
transcription factor
alternative RNA splicing
animal cell
controlled study
cystic fibrosis
DNA template
gene control
gene function
genetic code
genetic transcription
mammalian genetics
nonhuman
promoter region
protein RNA binding
proteomics
regulatory mechanism
review
Alternative Splicing
Animals
Models, Genetic
RNA Polymerase II
RNA Precursors
RNA, Messenger
RNA-Binding Proteins
Transcription, Genetic
Animalia
Mammalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15216543_v55_n4-5_p235_Nogues
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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