Observable effects of Ca2+ buffers on local Ca2+ signals

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Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have pr...

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Detalles Bibliográficos
Autores principales: Solovey, G., Dawson, S.P.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2010
Materias:
Buffers
Puffs
Sugars
Transport properties
High resolution
Local signal
Optical experiments
Physiological process
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.

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