Observable effects of Ca2+ buffers on local Ca2+ signals

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Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have pr...

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Detalles Bibliográficos
Autores principales: Solovey, G., Dawson, S.P.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2010
Materias:
Buffers
Puffs
Sugars
Transport properties
High resolution
Local signal
Optical experiments
Physiological process
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paperaa:paper_1364503X_v368_n1933_p5597_Solovey
record_format dspace
spelling paperaa:paper_1364503X_v368_n1933_p5597_Solovey2023-06-12T16:49:54Z Observable effects of Ca2+ buffers on local Ca2+ signals Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2010;368(1933):5597-5603 Solovey, G. Dawson, S.P. Buffers Puffs Sugars Transport properties Buffers High resolution Local signal Optical experiments Physiological process Puffs Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Buffers Calcium Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society. Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Inglés
orig_language_str_mv eng
topic Buffers
Puffs
Sugars
Transport properties
Buffers
High resolution
Local signal
Optical experiments
Physiological process
Puffs
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Buffers
Calcium
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
spellingShingle Buffers
Puffs
Sugars
Transport properties
Buffers
High resolution
Local signal
Optical experiments
Physiological process
Puffs
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Buffers
Calcium
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
Solovey, G.
Dawson, S.P.
Observable effects of Ca2+ buffers on local Ca2+ signals
topic_facet Buffers
Puffs
Sugars
Transport properties
Buffers
High resolution
Local signal
Optical experiments
Physiological process
Puffs
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Buffers
Calcium
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
description Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.
format Artículo
Artículo
publishedVersion
author Solovey, G.
Dawson, S.P.
author_facet Solovey, G.
Dawson, S.P.
author_sort Solovey, G.
title Observable effects of Ca2+ buffers on local Ca2+ signals
title_short Observable effects of Ca2+ buffers on local Ca2+ signals
title_full Observable effects of Ca2+ buffers on local Ca2+ signals
title_fullStr Observable effects of Ca2+ buffers on local Ca2+ signals
title_full_unstemmed Observable effects of Ca2+ buffers on local Ca2+ signals
title_sort observable effects of ca2+ buffers on local ca2+ signals
publishDate 2010
url http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey
work_keys_str_mv AT soloveyg observableeffectsofca2buffersonlocalca2signals
AT dawsonsp observableeffectsofca2buffersonlocalca2signals
_version_ 1769810243459481600

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