PKMζ inactivation induces spatial familiarity
Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated...
Guardado en:
Autores principales: | , |
---|---|
Formato: | Artículo publishedVersion |
Lenguaje: | Inglés |
Publicado: |
2008
|
Materias: | |
Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada |
Aporte de: |
id |
paperaa:paper_10720502_v15_n11_p810_Moncada |
---|---|
record_format |
dspace |
spelling |
paperaa:paper_10720502_v15_n11_p810_Moncada2023-06-12T16:49:28Z PKMζ inactivation induces spatial familiarity Learn. Mem. 2008;15(11):810-814 Moncada, D. Viola, H. protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place. © 2008 Cold Spring Harbor Laboratory Press. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
language |
Inglés |
orig_language_str_mv |
eng |
topic |
protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors |
spellingShingle |
protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors Moncada, D. Viola, H. PKMζ inactivation induces spatial familiarity |
topic_facet |
protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors |
description |
Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place. © 2008 Cold Spring Harbor Laboratory Press. |
format |
Artículo Artículo publishedVersion |
author |
Moncada, D. Viola, H. |
author_facet |
Moncada, D. Viola, H. |
author_sort |
Moncada, D. |
title |
PKMζ inactivation induces spatial familiarity |
title_short |
PKMζ inactivation induces spatial familiarity |
title_full |
PKMζ inactivation induces spatial familiarity |
title_fullStr |
PKMζ inactivation induces spatial familiarity |
title_full_unstemmed |
PKMζ inactivation induces spatial familiarity |
title_sort |
pkmζ inactivation induces spatial familiarity |
publishDate |
2008 |
url |
http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada |
work_keys_str_mv |
AT moncadad pkmzinactivationinducesspatialfamiliarity AT violah pkmzinactivationinducesspatialfamiliarity |
_version_ |
1769810344356610048 |