'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface

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Successful mammalian pregnancy relies upon acceptance of a semi-allogeneic fetus by the maternal immune system. Lessons learned from studies on protective immunity to microbial infections and tumours, prevention of autoimmunity, and allograft rejection have contributed to delineate the mechanisms le...

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Autores principales:	Blidner, A.G., Rabinovich, G.A.
Formato:	Artículo publishedVersion
Lenguaje:	Inglés
Publicado:	2013
Materias:	Angiogenesis Fetomaternal tolerance Galectins Immune privilege Implantation Pregnancy ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 glycan hypoxia inducible factor 1alpha immunoglobulin enhancer binding protein Janus kinase 2 lectin unclassified drug vasculotropin receptor 3 fetoplacental unit homeostasis human nonhuman pregnancy priority journal protein expression protein function review Cell Adhesion Cell Communication Cell Hypoxia Dendritic Cells Embryo Implantation Female Fetus Humans Immune Tolerance Neovascularization, Physiologic Signal Transduction T-Lymphocytes, Regulatory
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10467408_v69_n4_p369_Blidner
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paperaa:paper_10467408_v69_n4_p369_Blidner2023-06-12T16:49:00Z 'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface Am. J. Reprod. Immunol. 2013;69(4):369-382 Blidner, A.G. Rabinovich, G.A. Angiogenesis Fetomaternal tolerance Galectins Immune privilege Implantation Pregnancy ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 glycan hypoxia inducible factor 1alpha immunoglobulin enhancer binding protein Janus kinase 2 lectin unclassified drug vasculotropin receptor 3 fetoplacental unit homeostasis human nonhuman pregnancy priority journal protein expression protein function review Cell Adhesion Cell Communication Cell Hypoxia Dendritic Cells Embryo Implantation Female Fetus Galectins Humans Immune Tolerance Neovascularization, Physiologic Pregnancy Signal Transduction T-Lymphocytes, Regulatory Successful mammalian pregnancy relies upon acceptance of a semi-allogeneic fetus by the maternal immune system. Lessons learned from studies on protective immunity to microbial infections and tumours, prevention of autoimmunity, and allograft rejection have contributed to delineate the mechanisms leading to T-cell tolerance at the fetomaternal interface. Recent observations highlight the contribution of galectins, a family of endogenous glycan-binding proteins, to critical biological events occurring during mammalian gestation, including immune cell tolerance, inflammation, implantation, and angiogenesis. These multifunctional lectins can hierarchically control a cascade of immunoregulatory events including the expansion, recruitment, and function of regulatory T cells, the promotion of tolerogenic dendritic cells, and the execution of T-cell death programs. In addition, galectins can control cell adhesion and signaling events critical for implantation and are involved in fundamental processes linking tissue hypoxia to angiogenesis. In an attempt to integrate the regulatory roles of galectins to immunological and vascular programs operating during pregnancy. Here we outline the regulated expression and function of individual members of the galectin family within the fetoplacental unit and their biological implications for the development and preservation of successful pregnancies. © 2013 John Wiley & Sons A/S. Fil:Blidner, A.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10467408_v69_n4_p369_Blidner
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language	Inglés
orig_language_str_mv	eng
topic	Angiogenesis Fetomaternal tolerance Galectins Immune privilege Implantation Pregnancy ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 glycan hypoxia inducible factor 1alpha immunoglobulin enhancer binding protein Janus kinase 2 lectin unclassified drug vasculotropin receptor 3 fetoplacental unit homeostasis human nonhuman pregnancy priority journal protein expression protein function review Cell Adhesion Cell Communication Cell Hypoxia Dendritic Cells Embryo Implantation Female Fetus Galectins Humans Immune Tolerance Neovascularization, Physiologic Pregnancy Signal Transduction T-Lymphocytes, Regulatory
spellingShingle	Angiogenesis Fetomaternal tolerance Galectins Immune privilege Implantation Pregnancy ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 glycan hypoxia inducible factor 1alpha immunoglobulin enhancer binding protein Janus kinase 2 lectin unclassified drug vasculotropin receptor 3 fetoplacental unit homeostasis human nonhuman pregnancy priority journal protein expression protein function review Cell Adhesion Cell Communication Cell Hypoxia Dendritic Cells Embryo Implantation Female Fetus Galectins Humans Immune Tolerance Neovascularization, Physiologic Pregnancy Signal Transduction T-Lymphocytes, Regulatory Blidner, A.G. Rabinovich, G.A. 'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
topic_facet	Angiogenesis Fetomaternal tolerance Galectins Immune privilege Implantation Pregnancy ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 glycan hypoxia inducible factor 1alpha immunoglobulin enhancer binding protein Janus kinase 2 lectin unclassified drug vasculotropin receptor 3 fetoplacental unit homeostasis human nonhuman pregnancy priority journal protein expression protein function review Cell Adhesion Cell Communication Cell Hypoxia Dendritic Cells Embryo Implantation Female Fetus Galectins Humans Immune Tolerance Neovascularization, Physiologic Pregnancy Signal Transduction T-Lymphocytes, Regulatory
description	Successful mammalian pregnancy relies upon acceptance of a semi-allogeneic fetus by the maternal immune system. Lessons learned from studies on protective immunity to microbial infections and tumours, prevention of autoimmunity, and allograft rejection have contributed to delineate the mechanisms leading to T-cell tolerance at the fetomaternal interface. Recent observations highlight the contribution of galectins, a family of endogenous glycan-binding proteins, to critical biological events occurring during mammalian gestation, including immune cell tolerance, inflammation, implantation, and angiogenesis. These multifunctional lectins can hierarchically control a cascade of immunoregulatory events including the expansion, recruitment, and function of regulatory T cells, the promotion of tolerogenic dendritic cells, and the execution of T-cell death programs. In addition, galectins can control cell adhesion and signaling events critical for implantation and are involved in fundamental processes linking tissue hypoxia to angiogenesis. In an attempt to integrate the regulatory roles of galectins to immunological and vascular programs operating during pregnancy. Here we outline the regulated expression and function of individual members of the galectin family within the fetoplacental unit and their biological implications for the development and preservation of successful pregnancies. © 2013 John Wiley & Sons A/S.
format	Artículo Artículo publishedVersion
author	Blidner, A.G. Rabinovich, G.A.
author_facet	Blidner, A.G. Rabinovich, G.A.
author_sort	Blidner, A.G.
title	'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
title_short	'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
title_full	'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
title_fullStr	'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
title_full_unstemmed	'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
title_sort	'sweetening' pregnancy: galectins at the fetomaternal interface
publishDate	2013
url	http://hdl.handle.net/20.500.12110/paper_10467408_v69_n4_p369_Blidner
work_keys_str_mv	AT blidnerag sweeteningpregnancygalectinsatthefetomaternalinterface AT rabinovichga sweeteningpregnancygalectinsatthefetomaternalinterface
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'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface

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