Molecular biology and medicine at the end of the XXth century
This paper reviews basic concepts of modern molecular biology with the premise that its influence in today's medicine is so important that its knowledge cannot remain limited to a few experts. I first analyze the overall structure and organization of human genes, their split nature and the flow...
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2000
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00257680_v60_n1_p9_Kornblihtt |
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paperaa:paper_00257680_v60_n1_p9_Kornblihtt2023-06-12T16:45:10Z Molecular biology and medicine at the end of the XXth century Medicina (Argentina) 2000;60(1):9-16 Kornblihtt, A.R. Clonation Knock out mice Medicine Molecular biology Transgenic mice animal article cloning gene gene expression regulation gene therapy genetic engineering human medicine molecular biology mouse physiology transgenic animal transgenic mouse Animals Animals, Genetically Modified Cloning, Organism Gene Expression Regulation Gene Therapy Genes Genetic Engineering Humans Medicine Mice Mice, Transgenic Molecular Biology This paper reviews basic concepts of modern molecular biology with the premise that its influence in today's medicine is so important that its knowledge cannot remain limited to a few experts. I first analyze the overall structure and organization of human genes, their split nature and the flow of genetic information from DNA to protein. The role of transcriptional control in the regulation of gene expression and cell differentiation is described by introducing experimental examples that define the importance of "master" genes. Basic concepts of genetic engineering, the generation of transgenic and knock out animals and the uses of molecular biology in clinical diagnosis, paternity tests and forensic medicine are presented. Finally, I discuss the possibilities of gene therapy and the fantasies and realities of transgenesis and cloning by nuclear transplant in humans. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2000 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00257680_v60_n1_p9_Kornblihtt |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Clonation Knock out mice Medicine Molecular biology Transgenic mice animal article cloning gene gene expression regulation gene therapy genetic engineering human medicine molecular biology mouse physiology transgenic animal transgenic mouse Animals Animals, Genetically Modified Cloning, Organism Gene Expression Regulation Gene Therapy Genes Genetic Engineering Humans Medicine Mice Mice, Transgenic Molecular Biology |
| spellingShingle |
Clonation Knock out mice Medicine Molecular biology Transgenic mice animal article cloning gene gene expression regulation gene therapy genetic engineering human medicine molecular biology mouse physiology transgenic animal transgenic mouse Animals Animals, Genetically Modified Cloning, Organism Gene Expression Regulation Gene Therapy Genes Genetic Engineering Humans Medicine Mice Mice, Transgenic Molecular Biology Kornblihtt, A.R. Molecular biology and medicine at the end of the XXth century |
| topic_facet |
Clonation Knock out mice Medicine Molecular biology Transgenic mice animal article cloning gene gene expression regulation gene therapy genetic engineering human medicine molecular biology mouse physiology transgenic animal transgenic mouse Animals Animals, Genetically Modified Cloning, Organism Gene Expression Regulation Gene Therapy Genes Genetic Engineering Humans Medicine Mice Mice, Transgenic Molecular Biology |
| description |
This paper reviews basic concepts of modern molecular biology with the premise that its influence in today's medicine is so important that its knowledge cannot remain limited to a few experts. I first analyze the overall structure and organization of human genes, their split nature and the flow of genetic information from DNA to protein. The role of transcriptional control in the regulation of gene expression and cell differentiation is described by introducing experimental examples that define the importance of "master" genes. Basic concepts of genetic engineering, the generation of transgenic and knock out animals and the uses of molecular biology in clinical diagnosis, paternity tests and forensic medicine are presented. Finally, I discuss the possibilities of gene therapy and the fantasies and realities of transgenesis and cloning by nuclear transplant in humans. |
| format |
Artículo Artículo publishedVersion |
| author |
Kornblihtt, A.R. |
| author_facet |
Kornblihtt, A.R. |
| author_sort |
Kornblihtt, A.R. |
| title |
Molecular biology and medicine at the end of the XXth century |
| title_short |
Molecular biology and medicine at the end of the XXth century |
| title_full |
Molecular biology and medicine at the end of the XXth century |
| title_fullStr |
Molecular biology and medicine at the end of the XXth century |
| title_full_unstemmed |
Molecular biology and medicine at the end of the XXth century |
| title_sort |
molecular biology and medicine at the end of the xxth century |
| publishDate |
2000 |
| url |
http://hdl.handle.net/20.500.12110/paper_00257680_v60_n1_p9_Kornblihtt |
| work_keys_str_mv |
AT kornblihttar molecularbiologyandmedicineattheendofthexxthcentury |
| _version_ |
1769810381529677824 |