Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients

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Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropa...

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Autores principales: Wider, E.A., Ferranti, D., Mozzarelli, M.N., Giancarlo, H., Della Valle, M.G., Cimmino, V., Movia, R.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 1997
Materias:
porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling paperaa:paper_00257680_v57_n3_p275_Wider2023-06-12T16:45:09Z Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients Medicina (Argentina) 1997;57(3):275-280 Wider, E.A. Ferranti, D. Mozzarelli, M.N. Giancarlo, H. Della Valle, M.G. Cimmino, V. Movia, R. porphobilinogen synthase adult aged alcoholism article female human male metabolism middle aged Adult Aged Alcoholism Female Humans Male Middle Aged Porphobilinogen Synthase Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy. 1997 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Inglés
orig_language_str_mv eng
topic porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
spellingShingle porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
Wider, E.A.
Ferranti, D.
Mozzarelli, M.N.
Giancarlo, H.
Della Valle, M.G.
Cimmino, V.
Movia, R.
Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
topic_facet porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
description Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy.
format Artículo
Artículo
publishedVersion
author Wider, E.A.
Ferranti, D.
Mozzarelli, M.N.
Giancarlo, H.
Della Valle, M.G.
Cimmino, V.
Movia, R.
author_facet Wider, E.A.
Ferranti, D.
Mozzarelli, M.N.
Giancarlo, H.
Della Valle, M.G.
Cimmino, V.
Movia, R.
author_sort Wider, E.A.
title Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_short Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_full Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_fullStr Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_full_unstemmed Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_sort modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
publishDate 1997
url http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider
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