Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines

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Mice harboring three mouse mammary tumor virus (MMTV) variants develop pregnancy-dependent (PD) tumors that progress to pregnancy-independent (PI) behavior through successive passages. Herein, we identified 10 predominant insertions in PI transplants from 8 independent tumor lines. These mutations w...

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Autores principales: Gattelli, A., Zimberlin, M.N., Meiss, R.P., Castilla, L.H., Kordon, E.C.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2006
Materias:
animal tissue
article
breast cancer
controlled study
female
gene insertion
gene mutation
gene overexpression
int7 gene
mouse
Mouse mammary tumor oncovirus
nonhuman
nucleotide sequence
pregnancy
priority journal
reverse transcription polymerase chain reaction
rspo3 gene
tumor cell line
tumor growth
virus gene
Animals
Disease Models, Animal
Female
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mutation
Recombination, Genetic
Retroviridae Infections
Selection (Genetics)
Tumor Virus Infections
Mouse mammary tumor virus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0022538X_v80_n22_p11409_Gattelli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paperaa:paper_0022538X_v80_n22_p11409_Gattelli
record_format dspace
spelling paperaa:paper_0022538X_v80_n22_p11409_Gattelli2023-06-12T16:44:52Z Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines J. Virol. 2006;80(22):11409-11415 Gattelli, A. Zimberlin, M.N. Meiss, R.P. Castilla, L.H. Kordon, E.C. animal tissue article breast cancer controlled study female gene insertion gene mutation gene overexpression int7 gene mouse Mouse mammary tumor oncovirus nonhuman nucleotide sequence pregnancy priority journal reverse transcription polymerase chain reaction rspo3 gene tumor cell line tumor growth virus gene Animals Disease Models, Animal Female Mammary Neoplasms, Experimental Mammary Tumor Virus, Mouse Mice Mutation Recombination, Genetic Retroviridae Infections Selection (Genetics) Tumor Virus Infections Mouse mammary tumor virus Mice harboring three mouse mammary tumor virus (MMTV) variants develop pregnancy-dependent (PD) tumors that progress to pregnancy-independent (PI) behavior through successive passages. Herein, we identified 10 predominant insertions in PI transplants from 8 independent tumor lines. These mutations were also detected in small cell populations in the early PD passages. In addition, we identified a new viral insertion upstream of the gene Rspo3, which is overexpressed in three of the eight independent tumor lines and codes for a protein very similar to the recently described protein encoded by Int7. This study suggests that during progression towards hormone independence, clonal expansion of cells with specific mutations might be more relevant than the occurrence of new MMTV insertions. Copyright © 2006, American Society for Microbiology. All Rights Reserved. Fil:Kordon, E.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0022538X_v80_n22_p11409_Gattelli
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Inglés
orig_language_str_mv eng
topic animal tissue
article
breast cancer
controlled study
female
gene insertion
gene mutation
gene overexpression
int7 gene
mouse
Mouse mammary tumor oncovirus
nonhuman
nucleotide sequence
pregnancy
priority journal
reverse transcription polymerase chain reaction
rspo3 gene
tumor cell line
tumor growth
virus gene
Animals
Disease Models, Animal
Female
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mutation
Recombination, Genetic
Retroviridae Infections
Selection (Genetics)
Tumor Virus Infections
Mouse mammary tumor virus
spellingShingle animal tissue
article
breast cancer
controlled study
female
gene insertion
gene mutation
gene overexpression
int7 gene
mouse
Mouse mammary tumor oncovirus
nonhuman
nucleotide sequence
pregnancy
priority journal
reverse transcription polymerase chain reaction
rspo3 gene
tumor cell line
tumor growth
virus gene
Animals
Disease Models, Animal
Female
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mutation
Recombination, Genetic
Retroviridae Infections
Selection (Genetics)
Tumor Virus Infections
Mouse mammary tumor virus
Gattelli, A.
Zimberlin, M.N.
Meiss, R.P.
Castilla, L.H.
Kordon, E.C.
Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines
topic_facet animal tissue
article
breast cancer
controlled study
female
gene insertion
gene mutation
gene overexpression
int7 gene
mouse
Mouse mammary tumor oncovirus
nonhuman
nucleotide sequence
pregnancy
priority journal
reverse transcription polymerase chain reaction
rspo3 gene
tumor cell line
tumor growth
virus gene
Animals
Disease Models, Animal
Female
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mutation
Recombination, Genetic
Retroviridae Infections
Selection (Genetics)
Tumor Virus Infections
Mouse mammary tumor virus
description Mice harboring three mouse mammary tumor virus (MMTV) variants develop pregnancy-dependent (PD) tumors that progress to pregnancy-independent (PI) behavior through successive passages. Herein, we identified 10 predominant insertions in PI transplants from 8 independent tumor lines. These mutations were also detected in small cell populations in the early PD passages. In addition, we identified a new viral insertion upstream of the gene Rspo3, which is overexpressed in three of the eight independent tumor lines and codes for a protein very similar to the recently described protein encoded by Int7. This study suggests that during progression towards hormone independence, clonal expansion of cells with specific mutations might be more relevant than the occurrence of new MMTV insertions. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
format Artículo
Artículo
publishedVersion
author Gattelli, A.
Zimberlin, M.N.
Meiss, R.P.
Castilla, L.H.
Kordon, E.C.
author_facet Gattelli, A.
Zimberlin, M.N.
Meiss, R.P.
Castilla, L.H.
Kordon, E.C.
author_sort Gattelli, A.
title Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines
title_short Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines
title_full Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines
title_fullStr Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines
title_full_unstemmed Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines
title_sort selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines
publishDate 2006
url http://hdl.handle.net/20.500.12110/paper_0022538X_v80_n22_p11409_Gattelli
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AT meissrp selectionofearlyoccurringmutationsdictateshormoneindependentprogressioninmousemammarytumorlines
AT castillalh selectionofearlyoccurringmutationsdictateshormoneindependentprogressioninmousemammarytumorlines
AT kordonec selectionofearlyoccurringmutationsdictateshormoneindependentprogressioninmousemammarytumorlines
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