Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts

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1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in...

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Autores principales: Del C. Batlle, A.M., Bustos, N.L., Stella, A.M., Wider, E.A., Conti, H.A., Mendez, A.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 1983
Materias:
lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlle
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling paperaa:paper_0020711X_v15_n10_p1261_DelCBatlle2023-06-12T16:42:10Z Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts Int. J. Biochem. 1983;15(10):1261-1265 Del C. Batlle, A.M. Bustos, N.L. Stella, A.M. Wider, E.A. Conti, H.A. Mendez, A. lead porphobilinogen synthase blood and hemopoietic system case report drug therapy drug toxicity enzyme therapy erythrocyte ghost human intoxication lead poisoning porphyria therapy Adult Coproporphyrins Erythrocyte Membrane Humans Injections, Intravenous Lead Poisoning Male Porphobilinogen Synthase Porphyrins Uroporphyrins 1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bustos, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1983 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlle
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Inglés
orig_language_str_mv eng
topic lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins
spellingShingle lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins
Del C. Batlle, A.M.
Bustos, N.L.
Stella, A.M.
Wider, E.A.
Conti, H.A.
Mendez, A.
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
topic_facet lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins
description 1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983.
format Artículo
Artículo
publishedVersion
author Del C. Batlle, A.M.
Bustos, N.L.
Stella, A.M.
Wider, E.A.
Conti, H.A.
Mendez, A.
author_facet Del C. Batlle, A.M.
Bustos, N.L.
Stella, A.M.
Wider, E.A.
Conti, H.A.
Mendez, A.
author_sort Del C. Batlle, A.M.
title Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_short Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_full Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_fullStr Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_full_unstemmed Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_sort enzyme replacement therapy in porphyrias-iv. first successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
publishDate 1983
url http://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlle
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