Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response

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Functional interaction between the immune and neuroendocrine systems is mediated by humoral mediators, neurotransmitters, and cytokines, including TRH and PRL. We examined the role of neuroendocrine changes, particularly TRH and PRL, during the T cell-dependent immune response. After immunization of...

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Autores principales: Castro, C.P., Peñalva, R., Pereda, M.P., Renner, U., Reul, J.M.H.M., Stalla, G.K., Holsboer, F., Arzt, E.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 1999
Materias:
prolactin
protirelin
animal tissue
article
cellular immunity
immune response
male
nonhuman
priority journal
prolactin release
rat
sheep
T lymphocyte
thyrotropin release
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v140_n2_p690_Castro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paperaa:paper_00137227_v140_n2_p690_Castro
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spelling paperaa:paper_00137227_v140_n2_p690_Castro2023-06-12T16:41:36Z Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response Endocrinology 1999;140(2):690-697 Castro, C.P. Peñalva, R. Pereda, M.P. Renner, U. Reul, J.M.H.M. Stalla, G.K. Holsboer, F. Arzt, E. prolactin protirelin animal tissue article cellular immunity immune response male nonhuman priority journal prolactin release rat sheep T lymphocyte thyrotropin release Functional interaction between the immune and neuroendocrine systems is mediated by humoral mediators, neurotransmitters, and cytokines, including TRH and PRL. We examined the role of neuroendocrine changes, particularly TRH and PRL, during the T cell-dependent immune response. After immunization of rats with sheep red blood cells (SRBC, a T cell-dependent antigen), an increase of hypothalamic TRH messenger RNA (mRNA) was observed at 4-24 h post immunization, in contrast to the decrease observed after treatment with lipopolysaccharide (LPS). During the above period, with SRBC, there was an increase in pituitary TRH receptor mRNA and plasma PRL levels but no changes in TSH and GH. Also, in contrast to the early corticosterone peak induced by LPS, the activation of the hypothalamic-pituitary-adrenocortical suppressive response appears in a late phase, 5-7 days after SRBC. Intracerebroventricular injection of antisense oligonucleotide complementary to rat TRH mRNA in conscious freely-moving rats immunized with SRBC resulted in a significant inhibition of specific antibody production and a concomitant inability to produce the peak in plasma PRL levels. These studies demonstrate, for the first time, that the T cell-dependent immune response is critically dependent on the early activation of TRH and PRL and that the neuroendocrine changes occurring during it are profoundly different from those occurring during the T cell-independent and inflammatory responses (LPS model). Fil:Castro, C.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Peñalva, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pereda, M.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1999 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00137227_v140_n2_p690_Castro
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Inglés
orig_language_str_mv eng
topic prolactin
protirelin
animal tissue
article
cellular immunity
immune response
male
nonhuman
priority journal
prolactin release
rat
sheep
T lymphocyte
thyrotropin release
spellingShingle prolactin
protirelin
animal tissue
article
cellular immunity
immune response
male
nonhuman
priority journal
prolactin release
rat
sheep
T lymphocyte
thyrotropin release
Castro, C.P.
Peñalva, R.
Pereda, M.P.
Renner, U.
Reul, J.M.H.M.
Stalla, G.K.
Holsboer, F.
Arzt, E.
Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response
topic_facet prolactin
protirelin
animal tissue
article
cellular immunity
immune response
male
nonhuman
priority journal
prolactin release
rat
sheep
T lymphocyte
thyrotropin release
description Functional interaction between the immune and neuroendocrine systems is mediated by humoral mediators, neurotransmitters, and cytokines, including TRH and PRL. We examined the role of neuroendocrine changes, particularly TRH and PRL, during the T cell-dependent immune response. After immunization of rats with sheep red blood cells (SRBC, a T cell-dependent antigen), an increase of hypothalamic TRH messenger RNA (mRNA) was observed at 4-24 h post immunization, in contrast to the decrease observed after treatment with lipopolysaccharide (LPS). During the above period, with SRBC, there was an increase in pituitary TRH receptor mRNA and plasma PRL levels but no changes in TSH and GH. Also, in contrast to the early corticosterone peak induced by LPS, the activation of the hypothalamic-pituitary-adrenocortical suppressive response appears in a late phase, 5-7 days after SRBC. Intracerebroventricular injection of antisense oligonucleotide complementary to rat TRH mRNA in conscious freely-moving rats immunized with SRBC resulted in a significant inhibition of specific antibody production and a concomitant inability to produce the peak in plasma PRL levels. These studies demonstrate, for the first time, that the T cell-dependent immune response is critically dependent on the early activation of TRH and PRL and that the neuroendocrine changes occurring during it are profoundly different from those occurring during the T cell-independent and inflammatory responses (LPS model).
format Artículo
Artículo
publishedVersion
author Castro, C.P.
Peñalva, R.
Pereda, M.P.
Renner, U.
Reul, J.M.H.M.
Stalla, G.K.
Holsboer, F.
Arzt, E.
author_facet Castro, C.P.
Peñalva, R.
Pereda, M.P.
Renner, U.
Reul, J.M.H.M.
Stalla, G.K.
Holsboer, F.
Arzt, E.
author_sort Castro, C.P.
title Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response
title_short Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response
title_full Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response
title_fullStr Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response
title_full_unstemmed Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response
title_sort early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a t cell-dependent immune response
publishDate 1999
url http://hdl.handle.net/20.500.12110/paper_00137227_v140_n2_p690_Castro
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