Effect of in vivo administration of 5α reductase inhibitors on epididymal function
Progesterone, epitestosterone (4-androstene-17 α-o1-3-one, EpiT) and 4- androstene-3-one-17β-carboxylic acid (COOH), three known in vitro inhibitors of 5α reductase, were injected daily for 30 days into male rats to study their effect on some parameters of epididymal function. Progesterone at a dose...
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1979
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18557_v29_n1_p1_DeLarminat http://hdl.handle.net/20.500.12110/paper_NIS18557_v29_n1_p1_DeLarminat |
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paper:paper_NIS18557_v29_n1_p1_DeLarminat |
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paper:paper_NIS18557_v29_n1_p1_DeLarminat2023-06-08T16:39:46Z Effect of in vivo administration of 5α reductase inhibitors on epididymal function epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase Progesterone, epitestosterone (4-androstene-17 α-o1-3-one, EpiT) and 4- androstene-3-one-17β-carboxylic acid (COOH), three known in vitro inhibitors of 5α reductase, were injected daily for 30 days into male rats to study their effect on some parameters of epididymal function. Progesterone at a dose of 750 and 2000 μg/day decreased fertility by 59% and 50%, respectively. EpiT at a dose of 1 500 μg/day decreased fertility by 74%. These treatments did not change the sperm counts in the cauda epididynis. epididymis. with COOH did not decrease fertility. Progesterone at 750 and 2 000 μg/day and EpiT at 750 μg/day decreased the weight of the epididymis, prostate and seminal vesicles. None of the compounds tested produced variations in body weight or in the weight of liver and testis. The 5α reductase activity of epididymis, testis and liver was diminished by progesterone treatment, while EpiT decreased only that of testis and liver. 1979 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18557_v29_n1_p1_DeLarminat http://hdl.handle.net/20.500.12110/paper_NIS18557_v29_n1_p1_DeLarminat |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase |
| spellingShingle |
epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase Effect of in vivo administration of 5α reductase inhibitors on epididymal function |
| topic_facet |
epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase |
| description |
Progesterone, epitestosterone (4-androstene-17 α-o1-3-one, EpiT) and 4- androstene-3-one-17β-carboxylic acid (COOH), three known in vitro inhibitors of 5α reductase, were injected daily for 30 days into male rats to study their effect on some parameters of epididymal function. Progesterone at a dose of 750 and 2000 μg/day decreased fertility by 59% and 50%, respectively. EpiT at a dose of 1 500 μg/day decreased fertility by 74%. These treatments did not change the sperm counts in the cauda epididynis. epididymis. with COOH did not decrease fertility. Progesterone at 750 and 2 000 μg/day and EpiT at 750 μg/day decreased the weight of the epididymis, prostate and seminal vesicles. None of the compounds tested produced variations in body weight or in the weight of liver and testis. The 5α reductase activity of epididymis, testis and liver was diminished by progesterone treatment, while EpiT decreased only that of testis and liver. |
| title |
Effect of in vivo administration of 5α reductase inhibitors on epididymal function |
| title_short |
Effect of in vivo administration of 5α reductase inhibitors on epididymal function |
| title_full |
Effect of in vivo administration of 5α reductase inhibitors on epididymal function |
| title_fullStr |
Effect of in vivo administration of 5α reductase inhibitors on epididymal function |
| title_full_unstemmed |
Effect of in vivo administration of 5α reductase inhibitors on epididymal function |
| title_sort |
effect of in vivo administration of 5α reductase inhibitors on epididymal function |
| publishDate |
1979 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18557_v29_n1_p1_DeLarminat http://hdl.handle.net/20.500.12110/paper_NIS18557_v29_n1_p1_DeLarminat |
| _version_ |
1769175849629646848 |