Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats
In acute experiments aldosterone (aldo), 18-hydroxycorticosterone (18 OH B) or corticosterone (B) were administered to adrenalectomized rats and parameters related to acid-base balance determined in urine samples collected for 3.5 hours after injection. Aldo reduced sodium excretion but did not affe...
Guardado en:
| Publicado: |
1979
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18555_v29_n6_p305_Damasco http://hdl.handle.net/20.500.12110/paper_NIS18555_v29_n6_p305_Damasco |
| Aporte de: |
| id |
paper:paper_NIS18555_v29_n6_p305_Damasco |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_NIS18555_v29_n6_p305_Damasco2023-06-08T16:39:46Z Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats 18 hydroxycorticosterone aldosterone corticosterone potassium triamcinolone acid base balance adrenalectomy animal experiment bladder drug administration drug comparison drug efficacy electrolyte urine level endocrine system kidney rat urine ph 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Ammonium Compounds Animal Bicarbonates Comparative Study Corticosterone Kidney Male Phosphates Potassium Rats Rats, Inbred Strains Sodium Support, Non-U.S. Gov't In acute experiments aldosterone (aldo), 18-hydroxycorticosterone (18 OH B) or corticosterone (B) were administered to adrenalectomized rats and parameters related to acid-base balance determined in urine samples collected for 3.5 hours after injection. Aldo reduced sodium excretion but did not affect pH or the outputs of K, HN4+, CO3H-, phosphates, or titratable acidity. 18 OH B increased the excretion of titratable acidity and drastically reduced that of CO3H-. The lowest effective dose (3 μg) promoted Na excretion while the highest dose employed (6 μg) reduced pH and Na excretion. B increased the excretions of phosphates and ammonium, the former drastically. Potassium output either increased or did not change, and pH augmented marginally. It is postulated that a) 18 OH B is a naturally occurring steroid eliciting urine-acidification not necessarily accompanied by sodium retention; and b) in the rat B and 18OH B possess hormonal roles according to which the latter promotes the presence of protons, and the former, that of acute proton-acceptors in the lumen of tubuli. 1979 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18555_v29_n6_p305_Damasco http://hdl.handle.net/20.500.12110/paper_NIS18555_v29_n6_p305_Damasco |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
18 hydroxycorticosterone aldosterone corticosterone potassium triamcinolone acid base balance adrenalectomy animal experiment bladder drug administration drug comparison drug efficacy electrolyte urine level endocrine system kidney rat urine ph 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Ammonium Compounds Animal Bicarbonates Comparative Study Corticosterone Kidney Male Phosphates Potassium Rats Rats, Inbred Strains Sodium Support, Non-U.S. Gov't |
| spellingShingle |
18 hydroxycorticosterone aldosterone corticosterone potassium triamcinolone acid base balance adrenalectomy animal experiment bladder drug administration drug comparison drug efficacy electrolyte urine level endocrine system kidney rat urine ph 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Ammonium Compounds Animal Bicarbonates Comparative Study Corticosterone Kidney Male Phosphates Potassium Rats Rats, Inbred Strains Sodium Support, Non-U.S. Gov't Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats |
| topic_facet |
18 hydroxycorticosterone aldosterone corticosterone potassium triamcinolone acid base balance adrenalectomy animal experiment bladder drug administration drug comparison drug efficacy electrolyte urine level endocrine system kidney rat urine ph 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Ammonium Compounds Animal Bicarbonates Comparative Study Corticosterone Kidney Male Phosphates Potassium Rats Rats, Inbred Strains Sodium Support, Non-U.S. Gov't |
| description |
In acute experiments aldosterone (aldo), 18-hydroxycorticosterone (18 OH B) or corticosterone (B) were administered to adrenalectomized rats and parameters related to acid-base balance determined in urine samples collected for 3.5 hours after injection. Aldo reduced sodium excretion but did not affect pH or the outputs of K, HN4+, CO3H-, phosphates, or titratable acidity. 18 OH B increased the excretion of titratable acidity and drastically reduced that of CO3H-. The lowest effective dose (3 μg) promoted Na excretion while the highest dose employed (6 μg) reduced pH and Na excretion. B increased the excretions of phosphates and ammonium, the former drastically. Potassium output either increased or did not change, and pH augmented marginally. It is postulated that a) 18 OH B is a naturally occurring steroid eliciting urine-acidification not necessarily accompanied by sodium retention; and b) in the rat B and 18OH B possess hormonal roles according to which the latter promotes the presence of protons, and the former, that of acute proton-acceptors in the lumen of tubuli. |
| title |
Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats |
| title_short |
Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats |
| title_full |
Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats |
| title_fullStr |
Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats |
| title_full_unstemmed |
Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats |
| title_sort |
acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats |
| publishDate |
1979 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18555_v29_n6_p305_Damasco http://hdl.handle.net/20.500.12110/paper_NIS18555_v29_n6_p305_Damasco |
| _version_ |
1769175826203410432 |