Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes
This article discusses the experimental evidence which suggests that the pineal gland and its innervating neurons are useful paradigms for the study of neuroendocrine integrative processes. The obtained results can be summarized as follows: 1) existence of putative receptors for various hormones (es...
Guardado en:
| Publicado: |
1979
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18554_v29_n6_p291_Cardinali http://hdl.handle.net/20.500.12110/paper_NIS18554_v29_n6_p291_Cardinali |
| Aporte de: |
| id |
paper:paper_NIS18554_v29_n6_p291_Cardinali |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_NIS18554_v29_n6_p291_Cardinali2023-06-08T16:39:45Z Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes androgen estrogen gestagen hormone receptor prolactin radioisotope cell surface receptor melatonin neurotransmitter sex hormone autonomic nervous system central nervous system endocrine system neuroendocrinology pineal body review superior cervical ganglion testosterone h 3 adrenergic system animal biological model cattle chemical phenomena circadian rhythm estrus female hamster human light male metabolism ovulation physiology pineal body pregnancy rat sympathetic ganglion Animal Cattle Circadian Rhythm Depression, Chemical English Abstract Estrus Female Ganglia, Sympathetic Hamsters Human Light Male Melatonin Models, Biological Neurotransmitters Ovulation Pineal Gland Pregnancy Rats Receptors, Cell Surface Sex Hormones Support, Non-U.S. Gov't Sympathetic Nervous System This article discusses the experimental evidence which suggests that the pineal gland and its innervating neurons are useful paradigms for the study of neuroendocrine integrative processes. The obtained results can be summarized as follows: 1) existence of putative receptors for various hormones (estradiol, testosterone, 5α-dihydrotestosterone, progesterone, prolactin) in the mammalian pineal gland; (2) steroid metabolic pattern in the pineal gland resembling other brain areas involved in gonadotrophic regulation; (3) control of pineal estrophilic and androphilic receptors by adrenergic transmitter through β-adrenergic receptors and at a translational level; (4) denervation supersensitivity of hormone receptors to neurotransmitter; (5) modification of neuronal activity by hormone treatment at ganglionic and preganglionic sites of action; (6) estrophilic binding sites in ganglia; (7) correlation of pineal responsiveness to hormones with activity of sympathetic nerves; (8) modification by hormones of pineal β-adrenergic mechanisms (9) dissociation of hormone effects on the pineal gland in those mediated or modulated by changes in afferent neuronal activity and those relatively unaffected by denervation. Collectively these data indicate that neuroendocrine, endocrine-neural and endocrine-endocrine transducing processes occur in the pinealocytes and superior cervical ganglia. 1979 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18554_v29_n6_p291_Cardinali http://hdl.handle.net/20.500.12110/paper_NIS18554_v29_n6_p291_Cardinali |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
androgen estrogen gestagen hormone receptor prolactin radioisotope cell surface receptor melatonin neurotransmitter sex hormone autonomic nervous system central nervous system endocrine system neuroendocrinology pineal body review superior cervical ganglion testosterone h 3 adrenergic system animal biological model cattle chemical phenomena circadian rhythm estrus female hamster human light male metabolism ovulation physiology pineal body pregnancy rat sympathetic ganglion Animal Cattle Circadian Rhythm Depression, Chemical English Abstract Estrus Female Ganglia, Sympathetic Hamsters Human Light Male Melatonin Models, Biological Neurotransmitters Ovulation Pineal Gland Pregnancy Rats Receptors, Cell Surface Sex Hormones Support, Non-U.S. Gov't Sympathetic Nervous System |
| spellingShingle |
androgen estrogen gestagen hormone receptor prolactin radioisotope cell surface receptor melatonin neurotransmitter sex hormone autonomic nervous system central nervous system endocrine system neuroendocrinology pineal body review superior cervical ganglion testosterone h 3 adrenergic system animal biological model cattle chemical phenomena circadian rhythm estrus female hamster human light male metabolism ovulation physiology pineal body pregnancy rat sympathetic ganglion Animal Cattle Circadian Rhythm Depression, Chemical English Abstract Estrus Female Ganglia, Sympathetic Hamsters Human Light Male Melatonin Models, Biological Neurotransmitters Ovulation Pineal Gland Pregnancy Rats Receptors, Cell Surface Sex Hormones Support, Non-U.S. Gov't Sympathetic Nervous System Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes |
| topic_facet |
androgen estrogen gestagen hormone receptor prolactin radioisotope cell surface receptor melatonin neurotransmitter sex hormone autonomic nervous system central nervous system endocrine system neuroendocrinology pineal body review superior cervical ganglion testosterone h 3 adrenergic system animal biological model cattle chemical phenomena circadian rhythm estrus female hamster human light male metabolism ovulation physiology pineal body pregnancy rat sympathetic ganglion Animal Cattle Circadian Rhythm Depression, Chemical English Abstract Estrus Female Ganglia, Sympathetic Hamsters Human Light Male Melatonin Models, Biological Neurotransmitters Ovulation Pineal Gland Pregnancy Rats Receptors, Cell Surface Sex Hormones Support, Non-U.S. Gov't Sympathetic Nervous System |
| description |
This article discusses the experimental evidence which suggests that the pineal gland and its innervating neurons are useful paradigms for the study of neuroendocrine integrative processes. The obtained results can be summarized as follows: 1) existence of putative receptors for various hormones (estradiol, testosterone, 5α-dihydrotestosterone, progesterone, prolactin) in the mammalian pineal gland; (2) steroid metabolic pattern in the pineal gland resembling other brain areas involved in gonadotrophic regulation; (3) control of pineal estrophilic and androphilic receptors by adrenergic transmitter through β-adrenergic receptors and at a translational level; (4) denervation supersensitivity of hormone receptors to neurotransmitter; (5) modification of neuronal activity by hormone treatment at ganglionic and preganglionic sites of action; (6) estrophilic binding sites in ganglia; (7) correlation of pineal responsiveness to hormones with activity of sympathetic nerves; (8) modification by hormones of pineal β-adrenergic mechanisms (9) dissociation of hormone effects on the pineal gland in those mediated or modulated by changes in afferent neuronal activity and those relatively unaffected by denervation. Collectively these data indicate that neuroendocrine, endocrine-neural and endocrine-endocrine transducing processes occur in the pinealocytes and superior cervical ganglia. |
| title |
Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes |
| title_short |
Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes |
| title_full |
Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes |
| title_fullStr |
Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes |
| title_full_unstemmed |
Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes |
| title_sort |
neurohumoral control of the pineal gland. a model for the study of neuroendocrine integrative processes |
| publishDate |
1979 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18554_v29_n6_p291_Cardinali http://hdl.handle.net/20.500.12110/paper_NIS18554_v29_n6_p291_Cardinali |
| _version_ |
1769175825992646656 |