Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs

Many viral infections are associated with the development of immunopathologies and autoimmune diseases, of difficult treatment, for which no vaccines are available yet. Obtaining compounds that conjugate both antiviral and immunomodulating activities in the same molecule would be very useful for the...

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Autores principales: Alche, Laura Edith, Michelini, Flavia Mariana
Publicado: 2012
Materias:
Conjunctival cell lines
Herpes simplex virus
Herpetic stromal keratitis
Human corneal cell line
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p72_Alche
http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p72_Alche
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_97816080_v_n_p72_Alche
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spelling paper:paper_97816080_v_n_p72_Alche2023-06-08T16:38:12Z Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs Alche, Laura Edith Michelini, Flavia Mariana Conjunctival cell lines Herpes simplex virus Herpetic stromal keratitis Human corneal cell line Many viral infections are associated with the development of immunopathologies and autoimmune diseases, of difficult treatment, for which no vaccines are available yet. Obtaining compounds that conjugate both antiviral and immunomodulating activities in the same molecule would be very useful for the prevention and/or treatment of these immunopathologies of viral origin. Within this chapter, we present the evaluation of biological properties of synthetic brassinosteroids (BRs) analogs, and stigmastane and androstane derivatives, as potential antiviral and immunomodulating agents. We chose three synthetic BRs which had exhibited high antiviral activity against different human pathogenic viruses. The new steroidal molecules were designed with chemical modifications from the three BRs, in order to improve their antiviral activity. We also included some structural moieties responsible for the immunommodulating activity of well-known anti-inflammatory steroids. © 2011 Bentham Science Publishers. All rights reserved. Fil:Alche, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Michelini, F.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p72_Alche http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p72_Alche
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Conjunctival cell lines
Herpes simplex virus
Herpetic stromal keratitis
Human corneal cell line
spellingShingle Conjunctival cell lines
Herpes simplex virus
Herpetic stromal keratitis
Human corneal cell line
Alche, Laura Edith
Michelini, Flavia Mariana
Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs
topic_facet Conjunctival cell lines
Herpes simplex virus
Herpetic stromal keratitis
Human corneal cell line
description Many viral infections are associated with the development of immunopathologies and autoimmune diseases, of difficult treatment, for which no vaccines are available yet. Obtaining compounds that conjugate both antiviral and immunomodulating activities in the same molecule would be very useful for the prevention and/or treatment of these immunopathologies of viral origin. Within this chapter, we present the evaluation of biological properties of synthetic brassinosteroids (BRs) analogs, and stigmastane and androstane derivatives, as potential antiviral and immunomodulating agents. We chose three synthetic BRs which had exhibited high antiviral activity against different human pathogenic viruses. The new steroidal molecules were designed with chemical modifications from the three BRs, in order to improve their antiviral activity. We also included some structural moieties responsible for the immunommodulating activity of well-known anti-inflammatory steroids. © 2011 Bentham Science Publishers. All rights reserved.
author Alche, Laura Edith
Michelini, Flavia Mariana
author_facet Alche, Laura Edith
Michelini, Flavia Mariana
author_sort Alche, Laura Edith
title Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs
title_short Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs
title_full Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs
title_fullStr Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs
title_full_unstemmed Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs
title_sort antiherpetic and anti-inflammatory activities of novel synthetic brassinosteroids analogs
publishDate 2012
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p72_Alche
http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p72_Alche
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AT micheliniflaviamariana antiherpeticandantiinflammatoryactivitiesofnovelsyntheticbrassinosteroidsanalogs
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