Antiviral Properties of Brassinosteroids

In this chapter, we reviewed the antiviral activity of natural and synthetic brassinosteroids (BRs). Brassinolide and other natural BRs such as 28-homocastasterone present a broad antiviral spectrum against RNA and DNA viruses. Since the concentration of BRs in the plant tissue is very low, isolatio...

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Detalles Bibliográficos
Autores principales:	Wachsman, Mónica Beatriz, Castilla, Viviana
Publicado:	2012
Materias:	Herpes simplex virus Junín virus Measles virus Poliovirus Ribavirin Vesicular stomatitis
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p57_Wachsman http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p57_Wachsman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_97816080_v_n_p57_Wachsman
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spelling	paper:paper_97816080_v_n_p57_Wachsman2023-06-08T16:38:12Z Antiviral Properties of Brassinosteroids Wachsman, Mónica Beatriz Castilla, Viviana Herpes simplex virus Junín virus Measles virus Poliovirus Ribavirin Vesicular stomatitis In this chapter, we reviewed the antiviral activity of natural and synthetic brassinosteroids (BRs). Brassinolide and other natural BRs such as 28-homocastasterone present a broad antiviral spectrum against RNA and DNA viruses. Since the concentration of BRs in the plant tissue is very low, isolation of these compounds from plant sources is impractical, and they had to be obtained by chemical synthesis. The antiviral activity of a group of synthetic analogues against Herpes Simplex Type 1 and 2 (HSV-1 and HSV-2), Measles (MV), Vesicular Stomatitis Virus (VSV), Polio Virus (PV) and Arena Viruses was also determined. Several of the tested compounds showed selectivity indexes 10-to 18-fold higher than ribavirin, a broad spectrum antiviral compound, for Junín Virus (JUNV), a moderate activity against HSV-1/HSV-2 and good anti-MV, anti-PV and anti-VSV activity, with antiviral selectivity Index (SI) values also higher than ribavirin, a reference drug. Structure activity relationship Studies were performed in order to determine which stereochemistry, type and position of functional groups are needed to develop a potent and selective class of viral inhibitors. The antiviral mode of action of the BRs against HSV, JUNV and VSV was also investigated. For all assayed viruses, the antiviral compounds adversely affect virus protein synthesis and mature viral particle formation. © 2011 Bentham Science Publishers. All rights reserved. Fil:Wachsman, M.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p57_Wachsman http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p57_Wachsman
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Herpes simplex virus Junín virus Measles virus Poliovirus Ribavirin Vesicular stomatitis
spellingShingle	Herpes simplex virus Junín virus Measles virus Poliovirus Ribavirin Vesicular stomatitis Wachsman, Mónica Beatriz Castilla, Viviana Antiviral Properties of Brassinosteroids
topic_facet	Herpes simplex virus Junín virus Measles virus Poliovirus Ribavirin Vesicular stomatitis
description	In this chapter, we reviewed the antiviral activity of natural and synthetic brassinosteroids (BRs). Brassinolide and other natural BRs such as 28-homocastasterone present a broad antiviral spectrum against RNA and DNA viruses. Since the concentration of BRs in the plant tissue is very low, isolation of these compounds from plant sources is impractical, and they had to be obtained by chemical synthesis. The antiviral activity of a group of synthetic analogues against Herpes Simplex Type 1 and 2 (HSV-1 and HSV-2), Measles (MV), Vesicular Stomatitis Virus (VSV), Polio Virus (PV) and Arena Viruses was also determined. Several of the tested compounds showed selectivity indexes 10-to 18-fold higher than ribavirin, a broad spectrum antiviral compound, for Junín Virus (JUNV), a moderate activity against HSV-1/HSV-2 and good anti-MV, anti-PV and anti-VSV activity, with antiviral selectivity Index (SI) values also higher than ribavirin, a reference drug. Structure activity relationship Studies were performed in order to determine which stereochemistry, type and position of functional groups are needed to develop a potent and selective class of viral inhibitors. The antiviral mode of action of the BRs against HSV, JUNV and VSV was also investigated. For all assayed viruses, the antiviral compounds adversely affect virus protein synthesis and mature viral particle formation. © 2011 Bentham Science Publishers. All rights reserved.
author	Wachsman, Mónica Beatriz Castilla, Viviana
author_facet	Wachsman, Mónica Beatriz Castilla, Viviana
author_sort	Wachsman, Mónica Beatriz
title	Antiviral Properties of Brassinosteroids
title_short	Antiviral Properties of Brassinosteroids
title_full	Antiviral Properties of Brassinosteroids
title_fullStr	Antiviral Properties of Brassinosteroids
title_full_unstemmed	Antiviral Properties of Brassinosteroids
title_sort	antiviral properties of brassinosteroids
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p57_Wachsman http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p57_Wachsman
work_keys_str_mv	AT wachsmanmonicabeatriz antiviralpropertiesofbrassinosteroids AT castillaviviana antiviralpropertiesofbrassinosteroids
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Antiviral Properties of Brassinosteroids

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