Synthesis and biological activity of fluorinated brassinosteroids

Brassinosteroids have attracted considerable interest since 1979, when the isolation and structure determination of brassinolide was reported. Some brassinosteroids display powerful plant growth-regulating activity at doses as low as 1 ng per individual plant. Numerous studies of the chemistry and b...

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Autor principal: Ramirez, Javier Alberto
Publicado: 2008
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816045_v_n_p163_Ramirez
http://hdl.handle.net/20.500.12110/paper_97816045_v_n_p163_Ramirez
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_97816045_v_n_p163_Ramirez
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spelling paper:paper_97816045_v_n_p163_Ramirez2023-06-08T16:38:08Z Synthesis and biological activity of fluorinated brassinosteroids Ramirez, Javier Alberto Brassinosteroids have attracted considerable interest since 1979, when the isolation and structure determination of brassinolide was reported. Some brassinosteroids display powerful plant growth-regulating activity at doses as low as 1 ng per individual plant. Numerous studies of the chemistry and biology of brassinosteroids, as well as of their potential applications, have been reported. Organofluorine compounds have recently drawn considerable attention in the fields of agrochemistry, pharmaceutical and material science. Fluorinated analogues have been recognized as useful tools for pharmacological and physiological studies of natural products since the introduction of a fluorine atom into a molecule often leads to a significant change in its physical and biological properties. In view of their unique biological properties, fluorinated steroids have been widely studied and several fluoro-substituted compounds are now considered as analogues of plant hormones. This report reviews recent advances on the field of brassinosteroid research, with emphasis made in the work developed by our group and others on fluorinated analogues. The synthetic strategies leading to the introduction of fluorine atoms in the steroidal frame will be discussed. Finally, the biological properties of these fluorinated brassinosteroids, compared to their natural counterparts, will be analysed. © 2008 by Nova Science Publishers, Inc. All Rights Reserved. Fil:Ramírez, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816045_v_n_p163_Ramirez http://hdl.handle.net/20.500.12110/paper_97816045_v_n_p163_Ramirez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description Brassinosteroids have attracted considerable interest since 1979, when the isolation and structure determination of brassinolide was reported. Some brassinosteroids display powerful plant growth-regulating activity at doses as low as 1 ng per individual plant. Numerous studies of the chemistry and biology of brassinosteroids, as well as of their potential applications, have been reported. Organofluorine compounds have recently drawn considerable attention in the fields of agrochemistry, pharmaceutical and material science. Fluorinated analogues have been recognized as useful tools for pharmacological and physiological studies of natural products since the introduction of a fluorine atom into a molecule often leads to a significant change in its physical and biological properties. In view of their unique biological properties, fluorinated steroids have been widely studied and several fluoro-substituted compounds are now considered as analogues of plant hormones. This report reviews recent advances on the field of brassinosteroid research, with emphasis made in the work developed by our group and others on fluorinated analogues. The synthetic strategies leading to the introduction of fluorine atoms in the steroidal frame will be discussed. Finally, the biological properties of these fluorinated brassinosteroids, compared to their natural counterparts, will be analysed. © 2008 by Nova Science Publishers, Inc. All Rights Reserved.
author Ramirez, Javier Alberto
spellingShingle Ramirez, Javier Alberto
Synthesis and biological activity of fluorinated brassinosteroids
author_facet Ramirez, Javier Alberto
author_sort Ramirez, Javier Alberto
title Synthesis and biological activity of fluorinated brassinosteroids
title_short Synthesis and biological activity of fluorinated brassinosteroids
title_full Synthesis and biological activity of fluorinated brassinosteroids
title_fullStr Synthesis and biological activity of fluorinated brassinosteroids
title_full_unstemmed Synthesis and biological activity of fluorinated brassinosteroids
title_sort synthesis and biological activity of fluorinated brassinosteroids
publishDate 2008
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816045_v_n_p163_Ramirez
http://hdl.handle.net/20.500.12110/paper_97816045_v_n_p163_Ramirez
work_keys_str_mv AT ramirezjavieralberto synthesisandbiologicalactivityoffluorinatedbrassinosteroids
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