Simulación numérica del crecimiento de un tumor avascular

A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient...

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Publicado: 2016
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97814673_v_n_p_Weiman
http://hdl.handle.net/20.500.12110/paper_97814673_v_n_p_Weiman
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling paper:paper_97814673_v_n_p_Weiman2023-06-08T16:37:43Z Simulación numérica del crecimiento de un tumor avascular A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient concentration and a delay factor to the main equations of the model due to the release of cytostatic and cytotoxic factors from the necrotic core of the tumor. Lastly, we proposed a new delay model that led to a more suitable representation of the physiopathological phenomena in so far as the simulation shows the deceleration in the tumor growth and the decrease of proliferative cell density over time, as a consequence of the presence of the aforementioned cytostatic and cytotoxic factors. © 2016 IEEE. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97814673_v_n_p_Weiman http://hdl.handle.net/20.500.12110/paper_97814673_v_n_p_Weiman
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient concentration and a delay factor to the main equations of the model due to the release of cytostatic and cytotoxic factors from the necrotic core of the tumor. Lastly, we proposed a new delay model that led to a more suitable representation of the physiopathological phenomena in so far as the simulation shows the deceleration in the tumor growth and the decrease of proliferative cell density over time, as a consequence of the presence of the aforementioned cytostatic and cytotoxic factors. © 2016 IEEE.
title Simulación numérica del crecimiento de un tumor avascular
spellingShingle Simulación numérica del crecimiento de un tumor avascular
title_short Simulación numérica del crecimiento de un tumor avascular
title_full Simulación numérica del crecimiento de un tumor avascular
title_fullStr Simulación numérica del crecimiento de un tumor avascular
title_full_unstemmed Simulación numérica del crecimiento de un tumor avascular
title_sort simulación numérica del crecimiento de un tumor avascular
publishDate 2016
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97814673_v_n_p_Weiman
http://hdl.handle.net/20.500.12110/paper_97814673_v_n_p_Weiman
_version_ 1768543348579106816

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