Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression
Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites ar...
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2017
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_24700045_v95_n4_p_Lengyel http://hdl.handle.net/20.500.12110/paper_24700045_v95_n4_p_Lengyel |
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paper:paper_24700045_v95_n4_p_Lengyel2023-06-08T16:36:43Z Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression Bins Stochastic systems Transcription Gene products Multiple binding sites Negative autoregulation Noise suppression Protein level Single binding sites Theoretical study Transcriptional repressors Binding sites DNA transcription factor binding site biological model gene expression regulation kinetics Markov chain metabolism physiology protein degradation Binding Sites DNA Gene Expression Regulation Kinetics Models, Genetic Proteolysis Stochastic Processes Transcription Factors Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites are arranged in clusters. We study a stochastic description of negative autoregulation with multiple binding sites for the repressor. We find that increasing the number of binding sites induces regular bursting of gene products. By tuning the threshold for repression, we show that multiple binding sites can also suppress fluctuations. Our results highlight possible roles for the presence of multiple binding sites of negative autoregulators. © 2017 American Physical Society. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_24700045_v95_n4_p_Lengyel http://hdl.handle.net/20.500.12110/paper_24700045_v95_n4_p_Lengyel |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Bins Stochastic systems Transcription Gene products Multiple binding sites Negative autoregulation Noise suppression Protein level Single binding sites Theoretical study Transcriptional repressors Binding sites DNA transcription factor binding site biological model gene expression regulation kinetics Markov chain metabolism physiology protein degradation Binding Sites DNA Gene Expression Regulation Kinetics Models, Genetic Proteolysis Stochastic Processes Transcription Factors |
| spellingShingle |
Bins Stochastic systems Transcription Gene products Multiple binding sites Negative autoregulation Noise suppression Protein level Single binding sites Theoretical study Transcriptional repressors Binding sites DNA transcription factor binding site biological model gene expression regulation kinetics Markov chain metabolism physiology protein degradation Binding Sites DNA Gene Expression Regulation Kinetics Models, Genetic Proteolysis Stochastic Processes Transcription Factors Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression |
| topic_facet |
Bins Stochastic systems Transcription Gene products Multiple binding sites Negative autoregulation Noise suppression Protein level Single binding sites Theoretical study Transcriptional repressors Binding sites DNA transcription factor binding site biological model gene expression regulation kinetics Markov chain metabolism physiology protein degradation Binding Sites DNA Gene Expression Regulation Kinetics Models, Genetic Proteolysis Stochastic Processes Transcription Factors |
| description |
Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites are arranged in clusters. We study a stochastic description of negative autoregulation with multiple binding sites for the repressor. We find that increasing the number of binding sites induces regular bursting of gene products. By tuning the threshold for repression, we show that multiple binding sites can also suppress fluctuations. Our results highlight possible roles for the presence of multiple binding sites of negative autoregulators. © 2017 American Physical Society. |
| title |
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression |
| title_short |
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression |
| title_full |
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression |
| title_fullStr |
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression |
| title_full_unstemmed |
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression |
| title_sort |
multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression |
| publishDate |
2017 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_24700045_v95_n4_p_Lengyel http://hdl.handle.net/20.500.12110/paper_24700045_v95_n4_p_Lengyel |
| _version_ |
1768546183386497024 |