Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin

The effect of bile acids administration to an experimental mice model of Protoporphyria produced by griseofulvin (Gris) was investigated. The aim was to assess whether porphyrin excretion could be accelerated by bile acids treatment in an attempt to diminish liver damage induced by Gris. Liver damag...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martínez, María del Carmen, Afonso, Susana Graciela, Buzaleh, Ana María, Batlle, Alcira María del Carmen
Publicado:	2015
Materias:	alkaline phosphatase biological marker chenodeoxycholic acid cytochrome P450 dehydrocholic acid deoxycholic acid gamma glutamyltransferase glutathione glutathione reductase glutathione transferase griseofulvin heme porphyrin protoporphyrin superoxide dismutase ursodeoxycholic acid catalase glutathione peroxidase animal experiment animal model animal tissue Article biliary excretion controlled study drug effect drug efficacy enzyme activity erythropoietic protoporphyria immunohistochemistry lipid peroxidation liver histology liver injury male mouse nonhuman oxidative stress animal Chemical and Drug Induced Liver Injury chemically induced drug effects human metabolism pathology Protoporphyria, Erythropoietic Mus Animals Catalase Chenodeoxycholic Acid Dehydrocholic Acid Deoxycholic Acid Glutathione Peroxidase Glutathione Reductase Glutathione Transferase Griseofulvin Humans Lipid Peroxidation Mice Oxidative Stress Porphyrins Superoxide Dismutase Ursodeoxycholic Acid
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_23146133_v2015_n_p_Martinez http://hdl.handle.net/20.500.12110/paper_23146133_v2015_n_p_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_23146133_v2015_n_p_Martinez
record_format	dspace
spelling	paper:paper_23146133_v2015_n_p_Martinez2023-06-08T16:35:35Z Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin Martínez, María del Carmen Afonso, Susana Graciela Buzaleh, Ana María Batlle, Alcira María del Carmen alkaline phosphatase biological marker chenodeoxycholic acid cytochrome P450 dehydrocholic acid deoxycholic acid gamma glutamyltransferase glutathione glutathione reductase glutathione transferase griseofulvin heme porphyrin protoporphyrin superoxide dismutase ursodeoxycholic acid catalase chenodeoxycholic acid dehydrocholic acid deoxycholic acid glutathione peroxidase glutathione reductase glutathione transferase griseofulvin porphyrin superoxide dismutase ursodeoxycholic acid animal experiment animal model animal tissue Article biliary excretion controlled study drug effect drug efficacy enzyme activity erythropoietic protoporphyria immunohistochemistry lipid peroxidation liver histology liver injury male mouse nonhuman oxidative stress animal Chemical and Drug Induced Liver Injury chemically induced drug effects human metabolism pathology Protoporphyria, Erythropoietic Mus Animals Catalase Chemical and Drug Induced Liver Injury Chenodeoxycholic Acid Dehydrocholic Acid Deoxycholic Acid Glutathione Peroxidase Glutathione Reductase Glutathione Transferase Griseofulvin Humans Lipid Peroxidation Mice Oxidative Stress Porphyrins Protoporphyria, Erythropoietic Superoxide Dismutase Ursodeoxycholic Acid The effect of bile acids administration to an experimental mice model of Protoporphyria produced by griseofulvin (Gris) was investigated. The aim was to assess whether porphyrin excretion could be accelerated by bile acids treatment in an attempt to diminish liver damage induced by Gris. Liver damage markers, heme metabolism, and oxidative stress parameters were analyzed in mice treated with Gris and deoxycholic (DXA), dehydrocholic (DHA), chenodeoxycholic, or ursodeoxycholic (URSO). The administration of Gris alone increased the activities of glutathione reductase (GRed), superoxide dismutase (SOD), alkaline phosphatase (AP), gamma glutamyl transpeptidase (GGT), and glutathione-S-transferase (GST), as well as total porphyrins, glutathione (GSH), and cytochrome P450 (CYP) levels in liver. Among the bile acids studied, DXA and DHA increased PROTO IX excretion, DXA also abolished the action of Gris, reducing lipid peroxidation and hepatic GSH and CYP levels, and the activities of GGT, AP, SOD, and GST returned to control values. However, porphyrin accumulation was not prevented by URSO; instead this bile acid reduced ALA-S and the antioxidant defense enzymes system activities. In conclusion, we postulate that DXA acid would be more effective to prevent liver damage induced by Gris. © 2015 Mariá del Carmen Martinez et al. Fil:Martinez, M.D.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_23146133_v2015_n_p_Martinez http://hdl.handle.net/20.500.12110/paper_23146133_v2015_n_p_Martinez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	alkaline phosphatase biological marker chenodeoxycholic acid cytochrome P450 dehydrocholic acid deoxycholic acid gamma glutamyltransferase glutathione glutathione reductase glutathione transferase griseofulvin heme porphyrin protoporphyrin superoxide dismutase ursodeoxycholic acid catalase chenodeoxycholic acid dehydrocholic acid deoxycholic acid glutathione peroxidase glutathione reductase glutathione transferase griseofulvin porphyrin superoxide dismutase ursodeoxycholic acid animal experiment animal model animal tissue Article biliary excretion controlled study drug effect drug efficacy enzyme activity erythropoietic protoporphyria immunohistochemistry lipid peroxidation liver histology liver injury male mouse nonhuman oxidative stress animal Chemical and Drug Induced Liver Injury chemically induced drug effects human metabolism pathology Protoporphyria, Erythropoietic Mus Animals Catalase Chemical and Drug Induced Liver Injury Chenodeoxycholic Acid Dehydrocholic Acid Deoxycholic Acid Glutathione Peroxidase Glutathione Reductase Glutathione Transferase Griseofulvin Humans Lipid Peroxidation Mice Oxidative Stress Porphyrins Protoporphyria, Erythropoietic Superoxide Dismutase Ursodeoxycholic Acid
spellingShingle	alkaline phosphatase biological marker chenodeoxycholic acid cytochrome P450 dehydrocholic acid deoxycholic acid gamma glutamyltransferase glutathione glutathione reductase glutathione transferase griseofulvin heme porphyrin protoporphyrin superoxide dismutase ursodeoxycholic acid catalase chenodeoxycholic acid dehydrocholic acid deoxycholic acid glutathione peroxidase glutathione reductase glutathione transferase griseofulvin porphyrin superoxide dismutase ursodeoxycholic acid animal experiment animal model animal tissue Article biliary excretion controlled study drug effect drug efficacy enzyme activity erythropoietic protoporphyria immunohistochemistry lipid peroxidation liver histology liver injury male mouse nonhuman oxidative stress animal Chemical and Drug Induced Liver Injury chemically induced drug effects human metabolism pathology Protoporphyria, Erythropoietic Mus Animals Catalase Chemical and Drug Induced Liver Injury Chenodeoxycholic Acid Dehydrocholic Acid Deoxycholic Acid Glutathione Peroxidase Glutathione Reductase Glutathione Transferase Griseofulvin Humans Lipid Peroxidation Mice Oxidative Stress Porphyrins Protoporphyria, Erythropoietic Superoxide Dismutase Ursodeoxycholic Acid Martínez, María del Carmen Afonso, Susana Graciela Buzaleh, Ana María Batlle, Alcira María del Carmen Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin
topic_facet	alkaline phosphatase biological marker chenodeoxycholic acid cytochrome P450 dehydrocholic acid deoxycholic acid gamma glutamyltransferase glutathione glutathione reductase glutathione transferase griseofulvin heme porphyrin protoporphyrin superoxide dismutase ursodeoxycholic acid catalase chenodeoxycholic acid dehydrocholic acid deoxycholic acid glutathione peroxidase glutathione reductase glutathione transferase griseofulvin porphyrin superoxide dismutase ursodeoxycholic acid animal experiment animal model animal tissue Article biliary excretion controlled study drug effect drug efficacy enzyme activity erythropoietic protoporphyria immunohistochemistry lipid peroxidation liver histology liver injury male mouse nonhuman oxidative stress animal Chemical and Drug Induced Liver Injury chemically induced drug effects human metabolism pathology Protoporphyria, Erythropoietic Mus Animals Catalase Chemical and Drug Induced Liver Injury Chenodeoxycholic Acid Dehydrocholic Acid Deoxycholic Acid Glutathione Peroxidase Glutathione Reductase Glutathione Transferase Griseofulvin Humans Lipid Peroxidation Mice Oxidative Stress Porphyrins Protoporphyria, Erythropoietic Superoxide Dismutase Ursodeoxycholic Acid
description	The effect of bile acids administration to an experimental mice model of Protoporphyria produced by griseofulvin (Gris) was investigated. The aim was to assess whether porphyrin excretion could be accelerated by bile acids treatment in an attempt to diminish liver damage induced by Gris. Liver damage markers, heme metabolism, and oxidative stress parameters were analyzed in mice treated with Gris and deoxycholic (DXA), dehydrocholic (DHA), chenodeoxycholic, or ursodeoxycholic (URSO). The administration of Gris alone increased the activities of glutathione reductase (GRed), superoxide dismutase (SOD), alkaline phosphatase (AP), gamma glutamyl transpeptidase (GGT), and glutathione-S-transferase (GST), as well as total porphyrins, glutathione (GSH), and cytochrome P450 (CYP) levels in liver. Among the bile acids studied, DXA and DHA increased PROTO IX excretion, DXA also abolished the action of Gris, reducing lipid peroxidation and hepatic GSH and CYP levels, and the activities of GGT, AP, SOD, and GST returned to control values. However, porphyrin accumulation was not prevented by URSO; instead this bile acid reduced ALA-S and the antioxidant defense enzymes system activities. In conclusion, we postulate that DXA acid would be more effective to prevent liver damage induced by Gris. © 2015 Mariá del Carmen Martinez et al.
author	Martínez, María del Carmen Afonso, Susana Graciela Buzaleh, Ana María Batlle, Alcira María del Carmen
author_facet	Martínez, María del Carmen Afonso, Susana Graciela Buzaleh, Ana María Batlle, Alcira María del Carmen
author_sort	Martínez, María del Carmen
title	Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin
title_short	Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin
title_full	Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin
title_fullStr	Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin
title_full_unstemmed	Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin
title_sort	experimental protoporphyria: effect of bile acids on liver damage induced by griseofulvin
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_23146133_v2015_n_p_Martinez http://hdl.handle.net/20.500.12110/paper_23146133_v2015_n_p_Martinez
work_keys_str_mv	AT martinezmariadelcarmen experimentalprotoporphyriaeffectofbileacidsonliverdamageinducedbygriseofulvin AT afonsosusanagraciela experimentalprotoporphyriaeffectofbileacidsonliverdamageinducedbygriseofulvin AT buzalehanamaria experimentalprotoporphyriaeffectofbileacidsonliverdamageinducedbygriseofulvin AT batllealciramariadelcarmen experimentalprotoporphyriaeffectofbileacidsonliverdamageinducedbygriseofulvin
_version_	1768545997217071104

Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin

Ejemplares similares