Factoring the brain signatures of anesthesia concentration and level of arousal across individuals

Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis show...

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Autores principales:	Bekinschtein, Tristán Andres, Salles, Alejo, Sigman, Mariano
Publicado:	2015
Materias:	propofol hypnotic sedative agent oxygen adult anesthesia arousal Article brain drug blood level factorial analysis female frontal cortex frontoparietal cortex functional magnetic resonance imaging human human experiment male normal human nuclear magnetic resonance scanner priority journal response time sedation thalamus blood brain mapping drug effects factor analysis image processing middle aged nuclear magnetic resonance imaging regression analysis vascularization young adult Adult Arousal Brain Brain Mapping Factor Analysis, Statistical Female Humans Hypnotics and Sedatives Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Oxygen Propofol Regression Analysis Young Adult
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_22131582_v9_n_p385_Barttfeld http://hdl.handle.net/20.500.12110/paper_22131582_v9_n_p385_Barttfeld
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_22131582_v9_n_p385_Barttfeld
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spelling	paper:paper_22131582_v9_n_p385_Barttfeld2023-06-08T16:35:16Z Factoring the brain signatures of anesthesia concentration and level of arousal across individuals Bekinschtein, Tristán Andres Salles, Alejo Sigman, Mariano propofol hypnotic sedative agent oxygen propofol adult anesthesia arousal Article brain drug blood level factorial analysis female frontal cortex frontoparietal cortex functional magnetic resonance imaging human human experiment male normal human nuclear magnetic resonance scanner priority journal response time sedation thalamus arousal blood brain brain mapping drug effects factor analysis image processing middle aged nuclear magnetic resonance imaging regression analysis vascularization young adult Adult Arousal Brain Brain Mapping Factor Analysis, Statistical Female Humans Hypnotics and Sedatives Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Oxygen Propofol Regression Analysis Young Adult Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex. © 2015 The Authors. Fil:Bekinschtein, T.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Salles, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sigman, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_22131582_v9_n_p385_Barttfeld http://hdl.handle.net/20.500.12110/paper_22131582_v9_n_p385_Barttfeld
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	propofol hypnotic sedative agent oxygen propofol adult anesthesia arousal Article brain drug blood level factorial analysis female frontal cortex frontoparietal cortex functional magnetic resonance imaging human human experiment male normal human nuclear magnetic resonance scanner priority journal response time sedation thalamus arousal blood brain brain mapping drug effects factor analysis image processing middle aged nuclear magnetic resonance imaging regression analysis vascularization young adult Adult Arousal Brain Brain Mapping Factor Analysis, Statistical Female Humans Hypnotics and Sedatives Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Oxygen Propofol Regression Analysis Young Adult
spellingShingle	propofol hypnotic sedative agent oxygen propofol adult anesthesia arousal Article brain drug blood level factorial analysis female frontal cortex frontoparietal cortex functional magnetic resonance imaging human human experiment male normal human nuclear magnetic resonance scanner priority journal response time sedation thalamus arousal blood brain brain mapping drug effects factor analysis image processing middle aged nuclear magnetic resonance imaging regression analysis vascularization young adult Adult Arousal Brain Brain Mapping Factor Analysis, Statistical Female Humans Hypnotics and Sedatives Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Oxygen Propofol Regression Analysis Young Adult Bekinschtein, Tristán Andres Salles, Alejo Sigman, Mariano Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
topic_facet	propofol hypnotic sedative agent oxygen propofol adult anesthesia arousal Article brain drug blood level factorial analysis female frontal cortex frontoparietal cortex functional magnetic resonance imaging human human experiment male normal human nuclear magnetic resonance scanner priority journal response time sedation thalamus arousal blood brain brain mapping drug effects factor analysis image processing middle aged nuclear magnetic resonance imaging regression analysis vascularization young adult Adult Arousal Brain Brain Mapping Factor Analysis, Statistical Female Humans Hypnotics and Sedatives Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Oxygen Propofol Regression Analysis Young Adult
description	Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex. © 2015 The Authors.
author	Bekinschtein, Tristán Andres Salles, Alejo Sigman, Mariano
author_facet	Bekinschtein, Tristán Andres Salles, Alejo Sigman, Mariano
author_sort	Bekinschtein, Tristán Andres
title	Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_short	Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_full	Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_fullStr	Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_full_unstemmed	Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_sort	factoring the brain signatures of anesthesia concentration and level of arousal across individuals
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_22131582_v9_n_p385_Barttfeld http://hdl.handle.net/20.500.12110/paper_22131582_v9_n_p385_Barttfeld
work_keys_str_mv	AT bekinschteintristanandres factoringthebrainsignaturesofanesthesiaconcentrationandlevelofarousalacrossindividuals AT sallesalejo factoringthebrainsignaturesofanesthesiaconcentrationandlevelofarousalacrossindividuals AT sigmanmariano factoringthebrainsignaturesofanesthesiaconcentrationandlevelofarousalacrossindividuals
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Factoring the brain signatures of anesthesia concentration and level of arousal across individuals

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