The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emerg...
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2017
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_22111247_v19_n5_p939_Pietri http://hdl.handle.net/20.500.12110/paper_22111247_v19_n5_p939_Pietri |
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paper:paper_22111247_v19_n5_p939_Pietri2023-06-08T16:35:13Z The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs behavior development of spontaneous activity neuronal circuit dynamics optic tectum retinal input visual system zebrafish animal experiment animal tissue Article brain maturation controlled study electroencephalogram embryo functional connectivity hemisphere hemispheric dominance locomotion nonhuman tectum topography visual stimulation animal calcium signaling growth, development and aging metabolism photostimulation physiology retina superior colliculus vision visual system zebra fish Animals Calcium Signaling Photic Stimulation Retina Superior Colliculi Visual Pathways Visual Perception Zebrafish The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emergence of these patterns during development nor the role of retinal inputs in their maturation has been characterized. Using two-photon calcium imaging, we analyzed spontaneous activity in intact and enucleated zebrafish larvae throughout tectum development. At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity. Although the absence of retinal inputs had a significant impact on the development of the temporal structure, the tectum was still capable of developing a spatial structure associated with the circuit's functional roles and predictive of behavior. We conclude that neither visual experience nor intrinsic retinal activity is essential for the emergence of a spatially structured functional circuit. © 2017 The Author(s) 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_22111247_v19_n5_p939_Pietri http://hdl.handle.net/20.500.12110/paper_22111247_v19_n5_p939_Pietri |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
behavior development of spontaneous activity neuronal circuit dynamics optic tectum retinal input visual system zebrafish animal experiment animal tissue Article brain maturation controlled study electroencephalogram embryo functional connectivity hemisphere hemispheric dominance locomotion nonhuman tectum topography visual stimulation animal calcium signaling growth, development and aging metabolism photostimulation physiology retina superior colliculus vision visual system zebra fish Animals Calcium Signaling Photic Stimulation Retina Superior Colliculi Visual Pathways Visual Perception Zebrafish |
| spellingShingle |
behavior development of spontaneous activity neuronal circuit dynamics optic tectum retinal input visual system zebrafish animal experiment animal tissue Article brain maturation controlled study electroencephalogram embryo functional connectivity hemisphere hemispheric dominance locomotion nonhuman tectum topography visual stimulation animal calcium signaling growth, development and aging metabolism photostimulation physiology retina superior colliculus vision visual system zebra fish Animals Calcium Signaling Photic Stimulation Retina Superior Colliculi Visual Pathways Visual Perception Zebrafish The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs |
| topic_facet |
behavior development of spontaneous activity neuronal circuit dynamics optic tectum retinal input visual system zebrafish animal experiment animal tissue Article brain maturation controlled study electroencephalogram embryo functional connectivity hemisphere hemispheric dominance locomotion nonhuman tectum topography visual stimulation animal calcium signaling growth, development and aging metabolism photostimulation physiology retina superior colliculus vision visual system zebra fish Animals Calcium Signaling Photic Stimulation Retina Superior Colliculi Visual Pathways Visual Perception Zebrafish |
| description |
The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emergence of these patterns during development nor the role of retinal inputs in their maturation has been characterized. Using two-photon calcium imaging, we analyzed spontaneous activity in intact and enucleated zebrafish larvae throughout tectum development. At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity. Although the absence of retinal inputs had a significant impact on the development of the temporal structure, the tectum was still capable of developing a spatial structure associated with the circuit's functional roles and predictive of behavior. We conclude that neither visual experience nor intrinsic retinal activity is essential for the emergence of a spatially structured functional circuit. © 2017 The Author(s) |
| title |
The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs |
| title_short |
The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs |
| title_full |
The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs |
| title_fullStr |
The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs |
| title_full_unstemmed |
The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs |
| title_sort |
emergence of the spatial structure of tectal spontaneous activity is independent of visual inputs |
| publishDate |
2017 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_22111247_v19_n5_p939_Pietri http://hdl.handle.net/20.500.12110/paper_22111247_v19_n5_p939_Pietri |
| _version_ |
1768544106311581696 |