Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage

The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging proc...

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Autores principales:	Katche, Cynthia L., Viola, Haydée Ana María
Publicado:	2015
Materias:	arc protein brain derived neurotrophic factor brain protein dopamine 1 receptor dopamine 5 receptor unclassified drug activity regulated cytoskeletal-associated protein cytoskeleton protein nerve protein animal experiment Article controlled study dopaminergic nerve cell dorsal hippocampus evidence based practice exploratory behavior hippocampus long term memory long term potentiation male memory consolidation nonhuman protein expression protein synthesis rat short term memory signal processing training ventral tegmentum animal avoidance behavior biosynthesis environment motor activity physiology recognition Wistar rat Animals Avoidance Learning Cytoskeletal Proteins Environment Hippocampus Male Memory, Long-Term Motor Activity Nerve Tissue Proteins Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Recognition (Psychology)
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20905904_v2015_n_p_Tomaiuolo http://hdl.handle.net/20.500.12110/paper_20905904_v2015_n_p_Tomaiuolo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_20905904_v2015_n_p_Tomaiuolo
record_format	dspace
spelling	paper:paper_20905904_v2015_n_p_Tomaiuolo2023-06-08T16:34:18Z Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage Katche, Cynthia L. Viola, Haydée Ana María arc protein brain derived neurotrophic factor brain protein dopamine 1 receptor dopamine 5 receptor unclassified drug activity regulated cytoskeletal-associated protein cytoskeleton protein dopamine 1 receptor dopamine 5 receptor nerve protein animal experiment Article controlled study dopaminergic nerve cell dorsal hippocampus evidence based practice exploratory behavior hippocampus long term memory long term potentiation male memory consolidation nonhuman protein expression protein synthesis rat short term memory signal processing training ventral tegmentum animal avoidance behavior biosynthesis environment hippocampus long term memory motor activity physiology recognition Wistar rat Animals Avoidance Learning Cytoskeletal Proteins Environment Hippocampus Male Memory, Long-Term Motor Activity Nerve Tissue Proteins Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Recognition (Psychology) The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag. © 2015 Micol Tomaiuolo et al. Fil:Katche, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20905904_v2015_n_p_Tomaiuolo http://hdl.handle.net/20.500.12110/paper_20905904_v2015_n_p_Tomaiuolo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	arc protein brain derived neurotrophic factor brain protein dopamine 1 receptor dopamine 5 receptor unclassified drug activity regulated cytoskeletal-associated protein cytoskeleton protein dopamine 1 receptor dopamine 5 receptor nerve protein animal experiment Article controlled study dopaminergic nerve cell dorsal hippocampus evidence based practice exploratory behavior hippocampus long term memory long term potentiation male memory consolidation nonhuman protein expression protein synthesis rat short term memory signal processing training ventral tegmentum animal avoidance behavior biosynthesis environment hippocampus long term memory motor activity physiology recognition Wistar rat Animals Avoidance Learning Cytoskeletal Proteins Environment Hippocampus Male Memory, Long-Term Motor Activity Nerve Tissue Proteins Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Recognition (Psychology)
spellingShingle	arc protein brain derived neurotrophic factor brain protein dopamine 1 receptor dopamine 5 receptor unclassified drug activity regulated cytoskeletal-associated protein cytoskeleton protein dopamine 1 receptor dopamine 5 receptor nerve protein animal experiment Article controlled study dopaminergic nerve cell dorsal hippocampus evidence based practice exploratory behavior hippocampus long term memory long term potentiation male memory consolidation nonhuman protein expression protein synthesis rat short term memory signal processing training ventral tegmentum animal avoidance behavior biosynthesis environment hippocampus long term memory motor activity physiology recognition Wistar rat Animals Avoidance Learning Cytoskeletal Proteins Environment Hippocampus Male Memory, Long-Term Motor Activity Nerve Tissue Proteins Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Recognition (Psychology) Katche, Cynthia L. Viola, Haydée Ana María Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
topic_facet	arc protein brain derived neurotrophic factor brain protein dopamine 1 receptor dopamine 5 receptor unclassified drug activity regulated cytoskeletal-associated protein cytoskeleton protein dopamine 1 receptor dopamine 5 receptor nerve protein animal experiment Article controlled study dopaminergic nerve cell dorsal hippocampus evidence based practice exploratory behavior hippocampus long term memory long term potentiation male memory consolidation nonhuman protein expression protein synthesis rat short term memory signal processing training ventral tegmentum animal avoidance behavior biosynthesis environment hippocampus long term memory motor activity physiology recognition Wistar rat Animals Avoidance Learning Cytoskeletal Proteins Environment Hippocampus Male Memory, Long-Term Motor Activity Nerve Tissue Proteins Rats Rats, Wistar Receptors, Dopamine D1 Receptors, Dopamine D5 Recognition (Psychology)
description	The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag. © 2015 Micol Tomaiuolo et al.
author	Katche, Cynthia L. Viola, Haydée Ana María
author_facet	Katche, Cynthia L. Viola, Haydée Ana María
author_sort	Katche, Cynthia L.
title	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_short	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_full	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_fullStr	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_full_unstemmed	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_sort	evidence of maintenance tagging in the hippocampus for the persistence of long-lasting memory storage
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20905904_v2015_n_p_Tomaiuolo http://hdl.handle.net/20.500.12110/paper_20905904_v2015_n_p_Tomaiuolo
work_keys_str_mv	AT katchecynthial evidenceofmaintenancetagginginthehippocampusforthepersistenceoflonglastingmemorystorage AT violahaydeeanamaria evidenceofmaintenancetagginginthehippocampusforthepersistenceoflonglastingmemorystorage
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Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage

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