Core promoter information content correlates with optimal growth temperature

The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the...

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Detalles Bibliográficos
Publicado:	2018
Materias:	transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v8_n1_p_Aptekmann http://hdl.handle.net/20.500.12110/paper_20452322_v8_n1_p_Aptekmann
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_20452322_v8_n1_p_Aptekmann
record_format	dspace
spelling	paper:paper_20452322_v8_n1_p_Aptekmann2023-06-08T16:33:33Z Core promoter information content correlates with optimal growth temperature transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of each species and calculated its information content. We then studied the relation between optimal growth temperature (OGT) and information content (IC) in the promoter region.We found a positive correlation between G + C content and OGT in tRNA regions and not in overall genome. Furthermore, we found that there is a positive correlation between information content and optimal growth temperatures in Archaea. This can't be explained by an increased C+G composition nor by other obvious mechanisms. These findings suggest that increased information content could produce a positive fitness in organisms living at high temperatures. We suggest that molecular information theory may need to be adapted for hyperthermophiles. © 2018 The Author(s). 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v8_n1_p_Aptekmann http://hdl.handle.net/20.500.12110/paper_20452322_v8_n1_p_Aptekmann
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance
spellingShingle	transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance Core promoter information content correlates with optimal growth temperature
topic_facet	transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance
description	The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of each species and calculated its information content. We then studied the relation between optimal growth temperature (OGT) and information content (IC) in the promoter region.We found a positive correlation between G + C content and OGT in tRNA regions and not in overall genome. Furthermore, we found that there is a positive correlation between information content and optimal growth temperatures in Archaea. This can't be explained by an increased C+G composition nor by other obvious mechanisms. These findings suggest that increased information content could produce a positive fitness in organisms living at high temperatures. We suggest that molecular information theory may need to be adapted for hyperthermophiles. © 2018 The Author(s).
title	Core promoter information content correlates with optimal growth temperature
title_short	Core promoter information content correlates with optimal growth temperature
title_full	Core promoter information content correlates with optimal growth temperature
title_fullStr	Core promoter information content correlates with optimal growth temperature
title_full_unstemmed	Core promoter information content correlates with optimal growth temperature
title_sort	core promoter information content correlates with optimal growth temperature
publishDate	2018
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v8_n1_p_Aptekmann http://hdl.handle.net/20.500.12110/paper_20452322_v8_n1_p_Aptekmann
_version_	1768542666335715328

Core promoter information content correlates with optimal growth temperature

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