Novelty during a late postacquisition time window attenuates the persistence of fear memory

Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe manner remains unresolved....

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Detalles Bibliográficos
Autores principales:	Katche, Cynthia L., Viola, Haydée Ana María
Publicado:	2016
Materias:	animal avoidance behavior fear male memory rat Wistar rat Animals Avoidance Learning Fear Male Memory Rats Rats, Wistar
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v6_n_p_Katche http://hdl.handle.net/20.500.12110/paper_20452322_v6_n_p_Katche
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_20452322_v6_n_p_Katche
record_format	dspace
spelling	paper:paper_20452322_v6_n_p_Katche2023-06-08T16:33:26Z Novelty during a late postacquisition time window attenuates the persistence of fear memory Katche, Cynthia L. Viola, Haydée Ana María animal avoidance behavior fear male memory rat Wistar rat Animals Avoidance Learning Fear Male Memory Rats Rats, Wistar Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe manner remains unresolved. Here we show experiments employing a behavioural tool to target a specific time window after training to limit the persistence of a fear memory in rats. We observed that exposure to a novel environment 11 h after an inhibitory avoidance (IA) training that induces a long-lasting memory, attenuates the durability of IA memory but not its formation. This effect is time-restricted and not seen when the environment is familiar. In addition, novelty-induced attenuation of IA memory durability is prevented by the intrahippocampal infusion of the CaMKs inhibitor KN-93. This new behavioural approach which targets a specific time window during late memory consolidation, might represent a new tool for reducing the durability of persistent fear memories. © The Author(s) 2016. Fil:Katche, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v6_n_p_Katche http://hdl.handle.net/20.500.12110/paper_20452322_v6_n_p_Katche
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	animal avoidance behavior fear male memory rat Wistar rat Animals Avoidance Learning Fear Male Memory Rats Rats, Wistar
spellingShingle	animal avoidance behavior fear male memory rat Wistar rat Animals Avoidance Learning Fear Male Memory Rats Rats, Wistar Katche, Cynthia L. Viola, Haydée Ana María Novelty during a late postacquisition time window attenuates the persistence of fear memory
topic_facet	animal avoidance behavior fear male memory rat Wistar rat Animals Avoidance Learning Fear Male Memory Rats Rats, Wistar
description	Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe manner remains unresolved. Here we show experiments employing a behavioural tool to target a specific time window after training to limit the persistence of a fear memory in rats. We observed that exposure to a novel environment 11 h after an inhibitory avoidance (IA) training that induces a long-lasting memory, attenuates the durability of IA memory but not its formation. This effect is time-restricted and not seen when the environment is familiar. In addition, novelty-induced attenuation of IA memory durability is prevented by the intrahippocampal infusion of the CaMKs inhibitor KN-93. This new behavioural approach which targets a specific time window during late memory consolidation, might represent a new tool for reducing the durability of persistent fear memories. © The Author(s) 2016.
author	Katche, Cynthia L. Viola, Haydée Ana María
author_facet	Katche, Cynthia L. Viola, Haydée Ana María
author_sort	Katche, Cynthia L.
title	Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_short	Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_full	Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_fullStr	Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_full_unstemmed	Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_sort	novelty during a late postacquisition time window attenuates the persistence of fear memory
publishDate	2016
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v6_n_p_Katche http://hdl.handle.net/20.500.12110/paper_20452322_v6_n_p_Katche
work_keys_str_mv	AT katchecynthial noveltyduringalatepostacquisitiontimewindowattenuatesthepersistenceoffearmemory AT violahaydeeanamaria noveltyduringalatepostacquisitiontimewindowattenuatesthepersistenceoffearmemory
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Novelty during a late postacquisition time window attenuates the persistence of fear memory

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