Host cell factors as antiviral targets in arenavirus infection

Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and sa...

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Autores principales:	Linero, Florencia N., Sepúlveda, Claudia Soledad, Castilla, Viviana, García, Cybele Carina, Scolaro, Luis Alberto, Damonte, Elsa Beatriz
Publicado:	2012
Materias:	Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Host-Pathogen Interactions Humans Arenaviridae Lassa virus RNA viruses
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19994915_v4_n9_p1569_Linero http://hdl.handle.net/20.500.12110/paper_19994915_v4_n9_p1569_Linero
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_19994915_v4_n9_p1569_Linero
record_format	dspace
spelling	paper:paper_19994915_v4_n9_p1569_Linero2023-06-08T16:32:55Z Host cell factors as antiviral targets in arenavirus infection Linero, Florencia N. Sepúlveda, Claudia Soledad Castilla, Viviana García, Cybele Carina Scolaro, Luis Alberto Damonte, Elsa Beatriz Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Arenavirus Host-Pathogen Interactions Humans Arenaviridae Arenavirus Junin virus Lassa virus RNA viruses Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle, the targeting of a host process has turned an attractive antiviral approach in the last years for many unrelated virus types. This strategy has the additional benefit to reduce the serious challenge for therapy of RNA viruses to escape from drug effects through selection of resistant variants triggered by their high mutation rate. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing the potential for antiviral developments of diverse host factors essential for virus infection. © 2012 by the authors licensee MDPI, Basel, Switzerland. Fil:Linero, F.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sepúlveda, C.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:García, C.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Scolaro, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19994915_v4_n9_p1569_Linero http://hdl.handle.net/20.500.12110/paper_19994915_v4_n9_p1569_Linero
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Arenavirus Host-Pathogen Interactions Humans Arenaviridae Arenavirus Junin virus Lassa virus RNA viruses
spellingShingle	Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Arenavirus Host-Pathogen Interactions Humans Arenaviridae Arenavirus Junin virus Lassa virus RNA viruses Linero, Florencia N. Sepúlveda, Claudia Soledad Castilla, Viviana García, Cybele Carina Scolaro, Luis Alberto Damonte, Elsa Beatriz Host cell factors as antiviral targets in arenavirus infection
topic_facet	Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Arenavirus Host-Pathogen Interactions Humans Arenaviridae Arenavirus Junin virus Lassa virus RNA viruses
description	Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle, the targeting of a host process has turned an attractive antiviral approach in the last years for many unrelated virus types. This strategy has the additional benefit to reduce the serious challenge for therapy of RNA viruses to escape from drug effects through selection of resistant variants triggered by their high mutation rate. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing the potential for antiviral developments of diverse host factors essential for virus infection. © 2012 by the authors licensee MDPI, Basel, Switzerland.
author	Linero, Florencia N. Sepúlveda, Claudia Soledad Castilla, Viviana García, Cybele Carina Scolaro, Luis Alberto Damonte, Elsa Beatriz
author_facet	Linero, Florencia N. Sepúlveda, Claudia Soledad Castilla, Viviana García, Cybele Carina Scolaro, Luis Alberto Damonte, Elsa Beatriz
author_sort	Linero, Florencia N.
title	Host cell factors as antiviral targets in arenavirus infection
title_short	Host cell factors as antiviral targets in arenavirus infection
title_full	Host cell factors as antiviral targets in arenavirus infection
title_fullStr	Host cell factors as antiviral targets in arenavirus infection
title_full_unstemmed	Host cell factors as antiviral targets in arenavirus infection
title_sort	host cell factors as antiviral targets in arenavirus infection
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19994915_v4_n9_p1569_Linero http://hdl.handle.net/20.500.12110/paper_19994915_v4_n9_p1569_Linero
work_keys_str_mv	AT lineroflorencian hostcellfactorsasantiviraltargetsinarenavirusinfection AT sepulvedaclaudiasoledad hostcellfactorsasantiviraltargetsinarenavirusinfection AT castillaviviana hostcellfactorsasantiviraltargetsinarenavirusinfection AT garciacybelecarina hostcellfactorsasantiviraltargetsinarenavirusinfection AT scolaroluisalberto hostcellfactorsasantiviraltargetsinarenavirusinfection AT damonteelsabeatriz hostcellfactorsasantiviraltargetsinarenavirusinfection
_version_	1768544842380476416

Host cell factors as antiviral targets in arenavirus infection

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