CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs

Metabolic syndrome (MeS) has been identified as a risk factor for breast cancer. C-terminal binding protein 1 (CtBP1) is a co-repressor of tumor suppressor genes that is activated by low NAD+/NADH ratio. High fat diet (HFD) increases intracellular NADH. We investigated the effect of CtBP1 hyperactiv...

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Detalles Bibliográficos
Autores principales:	Moiola, Cristian Pablo, Porretti, Juliana C., Kordon, Edith Claudia, Todaro, Laura B., Vázquez, Elba Susana, De Siervi, Adriana
Publicado:	2016
Materias:	Breast cancer CtBP1 High fat diet Metabolic syndrome MiRNAs binding protein C terminal binding protein 1 cyclin D1 messenger RNA microRNA osteoprotegerin receptor activator of nuclear factor kappa B receptor interacting protein 140 short hairpin RNA transcription factor Slug transcription factor Snail unclassified drug vimentin alcohol dehydrogenase C-terminal binding protein DNA binding protein animal experiment animal model animal tissue Article breast cancer cell line breast carcinogenesis cancer risk cell communication cell cycle arrest cell proliferation colony formation controlled study development disease association down regulation epithelial mesenchymal transition female gene expression regulation gene targeting histopathology hypercholesterolemia hyperglycemia lipid diet mammary gland development metabolic syndrome X molecular dynamics mouse nonhuman phenotype postnatal development protein expression stem cell tumor growth tumor xenograft upregulation weight gain 3T3 cell line animal breast tumor genetics human MCF-7 cell line metabolism nude mouse randomization risk factor xenograft Alcohol Oxidoreductases Animals Breast Neoplasms Diet, High-Fat DNA-Binding Proteins Female Heterografts Humans MCF-7 Cells Metabolic Syndrome X Mice Mice, Nude MicroRNAs NIH 3T3 Cells Random Allocation Risk Factors
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19492553_v7_n14_p18798_DeLuca http://hdl.handle.net/20.500.12110/paper_19492553_v7_n14_p18798_DeLuca
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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