CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs
Metabolic syndrome (MeS) has been identified as a risk factor for breast cancer. C-terminal binding protein 1 (CtBP1) is a co-repressor of tumor suppressor genes that is activated by low NAD+/NADH ratio. High fat diet (HFD) increases intracellular NADH. We investigated the effect of CtBP1 hyperactiv...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19492553_v7_n14_p18798_DeLuca http://hdl.handle.net/20.500.12110/paper_19492553_v7_n14_p18798_DeLuca |
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paper:paper_19492553_v7_n14_p18798_DeLuca2023-06-08T16:32:37Z CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs Moiola, Cristian Pablo Porretti, Juliana C. Kordon, Edith Claudia Todaro, Laura B. Vázquez, Elba Susana De Siervi, Adriana Breast cancer CtBP1 High fat diet Metabolic syndrome MiRNAs binding protein C terminal binding protein 1 cyclin D1 messenger RNA microRNA osteoprotegerin receptor activator of nuclear factor kappa B receptor interacting protein 140 short hairpin RNA transcription factor Slug transcription factor Snail unclassified drug vimentin alcohol dehydrogenase C-terminal binding protein DNA binding protein microRNA animal experiment animal model animal tissue Article breast cancer cell line breast carcinogenesis cancer risk cell communication cell cycle arrest cell proliferation colony formation controlled study development disease association down regulation epithelial mesenchymal transition female gene expression regulation gene targeting histopathology hypercholesterolemia hyperglycemia lipid diet mammary gland development metabolic syndrome X molecular dynamics mouse nonhuman phenotype postnatal development protein expression stem cell tumor growth tumor xenograft upregulation weight gain 3T3 cell line animal breast tumor genetics human MCF-7 cell line metabolic syndrome X metabolism nude mouse randomization risk factor xenograft Alcohol Oxidoreductases Animals Breast Neoplasms Diet, High-Fat DNA-Binding Proteins Female Heterografts Humans MCF-7 Cells Metabolic Syndrome X Mice Mice, Nude MicroRNAs NIH 3T3 Cells Random Allocation Risk Factors Metabolic syndrome (MeS) has been identified as a risk factor for breast cancer. C-terminal binding protein 1 (CtBP1) is a co-repressor of tumor suppressor genes that is activated by low NAD+/NADH ratio. High fat diet (HFD) increases intracellular NADH. We investigated the effect of CtBP1 hyperactivation by HFD intake on mouse breast carcinogenesis. We generated a MeS-like disease in female mice by chronically feeding animals with HFD. MeS increased postnatal mammary gland development and generated prominent duct patterns with markedly increased CtBP1 and Cyclin D1 expression. CtBP1 induced breast cancer cells proliferation. Serum from animals with MeS enriched the stem-like/progenitor cell population from breast cancer cells. CtBP1 increased breast tumor growth in MeS mice modulating multiple genes and miRNA expression implicated in cell proliferation, progenitor cells phenotype, epithelial to mesenchymal transition, mammary development and cell communication in the xenografts. These results define a novel function for CtBP1 in breast carcinogenesis. Fil:Moiola, C.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Porretti, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kordon, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Todaro, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De Siervi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19492553_v7_n14_p18798_DeLuca http://hdl.handle.net/20.500.12110/paper_19492553_v7_n14_p18798_DeLuca |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Breast cancer CtBP1 High fat diet Metabolic syndrome MiRNAs binding protein C terminal binding protein 1 cyclin D1 messenger RNA microRNA osteoprotegerin receptor activator of nuclear factor kappa B receptor interacting protein 140 short hairpin RNA transcription factor Slug transcription factor Snail unclassified drug vimentin alcohol dehydrogenase C-terminal binding protein DNA binding protein microRNA animal experiment animal model animal tissue Article breast cancer cell line breast carcinogenesis cancer risk cell communication cell cycle arrest cell proliferation colony formation controlled study development disease association down regulation epithelial mesenchymal transition female gene expression regulation gene targeting histopathology hypercholesterolemia hyperglycemia lipid diet mammary gland development metabolic syndrome X molecular dynamics mouse nonhuman phenotype postnatal development protein expression stem cell tumor growth tumor xenograft upregulation weight gain 3T3 cell line animal breast tumor genetics human MCF-7 cell line metabolic syndrome X metabolism nude mouse randomization risk factor xenograft Alcohol Oxidoreductases Animals Breast Neoplasms Diet, High-Fat DNA-Binding Proteins Female Heterografts Humans MCF-7 Cells Metabolic Syndrome X Mice Mice, Nude MicroRNAs NIH 3T3 Cells Random Allocation Risk Factors |
spellingShingle |
Breast cancer CtBP1 High fat diet Metabolic syndrome MiRNAs binding protein C terminal binding protein 1 cyclin D1 messenger RNA microRNA osteoprotegerin receptor activator of nuclear factor kappa B receptor interacting protein 140 short hairpin RNA transcription factor Slug transcription factor Snail unclassified drug vimentin alcohol dehydrogenase C-terminal binding protein DNA binding protein microRNA animal experiment animal model animal tissue Article breast cancer cell line breast carcinogenesis cancer risk cell communication cell cycle arrest cell proliferation colony formation controlled study development disease association down regulation epithelial mesenchymal transition female gene expression regulation gene targeting histopathology hypercholesterolemia hyperglycemia lipid diet mammary gland development metabolic syndrome X molecular dynamics mouse nonhuman phenotype postnatal development protein expression stem cell tumor growth tumor xenograft upregulation weight gain 3T3 cell line animal breast tumor genetics human MCF-7 cell line metabolic syndrome X metabolism nude mouse randomization risk factor xenograft Alcohol Oxidoreductases Animals Breast Neoplasms Diet, High-Fat DNA-Binding Proteins Female Heterografts Humans MCF-7 Cells Metabolic Syndrome X Mice Mice, Nude MicroRNAs NIH 3T3 Cells Random Allocation Risk Factors Moiola, Cristian Pablo Porretti, Juliana C. Kordon, Edith Claudia Todaro, Laura B. Vázquez, Elba Susana De Siervi, Adriana CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs |
topic_facet |
Breast cancer CtBP1 High fat diet Metabolic syndrome MiRNAs binding protein C terminal binding protein 1 cyclin D1 messenger RNA microRNA osteoprotegerin receptor activator of nuclear factor kappa B receptor interacting protein 140 short hairpin RNA transcription factor Slug transcription factor Snail unclassified drug vimentin alcohol dehydrogenase C-terminal binding protein DNA binding protein microRNA animal experiment animal model animal tissue Article breast cancer cell line breast carcinogenesis cancer risk cell communication cell cycle arrest cell proliferation colony formation controlled study development disease association down regulation epithelial mesenchymal transition female gene expression regulation gene targeting histopathology hypercholesterolemia hyperglycemia lipid diet mammary gland development metabolic syndrome X molecular dynamics mouse nonhuman phenotype postnatal development protein expression stem cell tumor growth tumor xenograft upregulation weight gain 3T3 cell line animal breast tumor genetics human MCF-7 cell line metabolic syndrome X metabolism nude mouse randomization risk factor xenograft Alcohol Oxidoreductases Animals Breast Neoplasms Diet, High-Fat DNA-Binding Proteins Female Heterografts Humans MCF-7 Cells Metabolic Syndrome X Mice Mice, Nude MicroRNAs NIH 3T3 Cells Random Allocation Risk Factors |
description |
Metabolic syndrome (MeS) has been identified as a risk factor for breast cancer. C-terminal binding protein 1 (CtBP1) is a co-repressor of tumor suppressor genes that is activated by low NAD+/NADH ratio. High fat diet (HFD) increases intracellular NADH. We investigated the effect of CtBP1 hyperactivation by HFD intake on mouse breast carcinogenesis. We generated a MeS-like disease in female mice by chronically feeding animals with HFD. MeS increased postnatal mammary gland development and generated prominent duct patterns with markedly increased CtBP1 and Cyclin D1 expression. CtBP1 induced breast cancer cells proliferation. Serum from animals with MeS enriched the stem-like/progenitor cell population from breast cancer cells. CtBP1 increased breast tumor growth in MeS mice modulating multiple genes and miRNA expression implicated in cell proliferation, progenitor cells phenotype, epithelial to mesenchymal transition, mammary development and cell communication in the xenografts. These results define a novel function for CtBP1 in breast carcinogenesis. |
author |
Moiola, Cristian Pablo Porretti, Juliana C. Kordon, Edith Claudia Todaro, Laura B. Vázquez, Elba Susana De Siervi, Adriana |
author_facet |
Moiola, Cristian Pablo Porretti, Juliana C. Kordon, Edith Claudia Todaro, Laura B. Vázquez, Elba Susana De Siervi, Adriana |
author_sort |
Moiola, Cristian Pablo |
title |
CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs |
title_short |
CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs |
title_full |
CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs |
title_fullStr |
CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs |
title_full_unstemmed |
CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs |
title_sort |
ctbp1 associates metabolic syndrome and breast carcinogenesis targeting multiple mirnas |
publishDate |
2016 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19492553_v7_n14_p18798_DeLuca http://hdl.handle.net/20.500.12110/paper_19492553_v7_n14_p18798_DeLuca |
work_keys_str_mv |
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_version_ |
1768546274580103168 |