Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation

Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation patterns can be affected by neural cell excitation in...

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Detalles Bibliográficos
Autores principales:	Schor, Ignacio Esteban, Kornblihtt, Alberto Rodolfo
Publicado:	2009
Materias:	Alternative splicing Chromatin Histone acetylation NCAM Neuronal excitation Structure Transcriptional elongation
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19420889_v2_n4_p341_Schor http://hdl.handle.net/20.500.12110/paper_19420889_v2_n4_p341_Schor
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_19420889_v2_n4_p341_Schor
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spelling	paper:paper_19420889_v2_n4_p341_Schor2023-06-08T16:32:21Z Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo Alternative splicing Chromatin Histone acetylation NCAM Neuronal excitation Structure Transcriptional elongation Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation patterns can be affected by neural cell excitation in order to regulate alternative splicing of the neural cell adhesion molecule (NCAM) mRNA. This example illustrates how an extracellular stimulus can influence transcription-coupled alternative splicing, strengthening the link between chromatin structure, transcriptional elongation and mRNA processing. ©2009 Landes Bioscience. Fil:Schor, I.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19420889_v2_n4_p341_Schor http://hdl.handle.net/20.500.12110/paper_19420889_v2_n4_p341_Schor
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alternative splicing Chromatin Histone acetylation NCAM Neuronal excitation Structure Transcriptional elongation
spellingShingle	Alternative splicing Chromatin Histone acetylation NCAM Neuronal excitation Structure Transcriptional elongation Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
topic_facet	Alternative splicing Chromatin Histone acetylation NCAM Neuronal excitation Structure Transcriptional elongation
description	Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation patterns can be affected by neural cell excitation in order to regulate alternative splicing of the neural cell adhesion molecule (NCAM) mRNA. This example illustrates how an extracellular stimulus can influence transcription-coupled alternative splicing, strengthening the link between chromatin structure, transcriptional elongation and mRNA processing. ©2009 Landes Bioscience.
author	Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo
author_facet	Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo
author_sort	Schor, Ignacio Esteban
title	Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_short	Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_full	Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_fullStr	Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_full_unstemmed	Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_sort	playing inside the genes: intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
publishDate	2009
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19420889_v2_n4_p341_Schor http://hdl.handle.net/20.500.12110/paper_19420889_v2_n4_p341_Schor
work_keys_str_mv	AT schorignacioesteban playinginsidethegenesintragenichistoneacetylationaftermembranedepolarizationofneuralcellsopensapathforalternativesplicingregulation AT kornblihttalbertorodolfo playinginsidethegenesintragenichistoneacetylationaftermembranedepolarizationofneuralcellsopensapathforalternativesplicingregulation
_version_	1768545071587655680

Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation

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