Transcriptional elongation and alternative splicing

Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some o...

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Detalles Bibliográficos
Autores principales:	Lafaille, Celina, Petrillo, Ezequiel, Gomez Acuña, Luciana Ines, Fiszbein, Ana, Godoy Herz, Micaela Amalia, Muñoz, Manuel Javier, Allo, Mariano, Schor, Ignacio Esteban, Kornblihtt, Alberto Rodolfo
Publicado:	2013
Materias:	Alternative splicing Pol II elongation Transcription alpha tropomyosin caspase 9 DNA dystrophin fibronectin histone deacetylase 1 histone deacetylase 2 histone H2A histone H3 histone H4 MED23 protein mediator complex messenger RNA protein bcl x protein tyrosine kinase RNA RNA polymerase II serine small nuclear ribonucleoprotein transactivator protein unclassified drug 3' untranslated region 5' untranslated region alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly chromatin structure exon gene control gene expression genomic instability histone methylation human in vitro study in vivo study intron kinetics nonhuman nucleosome priority journal protein phosphorylation protein synthesis proteomics reverse transcription polymerase chain reaction review RNA sequence RNA synthesis transcription elongation transcription regulation Xenopus yeast Alternative Splicing Animals Chromatin Humans Kinetics Models, Biological Protein Binding RNA Polymerase II Transcription Elongation, Genetic
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18749399_v1829_n1_p134_Dujardin http://hdl.handle.net/20.500.12110/paper_18749399_v1829_n1_p134_Dujardin
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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Sumario:	Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of alternative splicing regulation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation. © 2012 Elsevier B.V.

Transcriptional elongation and alternative splicing

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