Transcriptional elongation and alternative splicing

Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some o...

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Autores principales:	Lafaille, Celina, Petrillo, Ezequiel, Gomez Acuña, Luciana Ines, Fiszbein, Ana, Godoy Herz, Micaela Amalia, Muñoz, Manuel Javier, Allo, Mariano, Schor, Ignacio Esteban, Kornblihtt, Alberto Rodolfo
Publicado:	2013
Materias:	Alternative splicing Pol II elongation Transcription alpha tropomyosin caspase 9 DNA dystrophin fibronectin histone deacetylase 1 histone deacetylase 2 histone H2A histone H3 histone H4 MED23 protein mediator complex messenger RNA protein bcl x protein tyrosine kinase RNA RNA polymerase II serine small nuclear ribonucleoprotein transactivator protein unclassified drug 3' untranslated region 5' untranslated region alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly chromatin structure exon gene control gene expression genomic instability histone methylation human in vitro study in vivo study intron kinetics nonhuman nucleosome priority journal protein phosphorylation protein synthesis proteomics reverse transcription polymerase chain reaction review RNA sequence RNA synthesis transcription elongation transcription regulation Xenopus yeast Alternative Splicing Animals Chromatin Humans Kinetics Models, Biological Protein Binding RNA Polymerase II Transcription Elongation, Genetic
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18749399_v1829_n1_p134_Dujardin http://hdl.handle.net/20.500.12110/paper_18749399_v1829_n1_p134_Dujardin
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_18749399_v1829_n1_p134_Dujardin
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spelling	paper:paper_18749399_v1829_n1_p134_Dujardin2023-06-08T16:30:08Z Transcriptional elongation and alternative splicing Lafaille, Celina Petrillo, Ezequiel Gomez Acuña, Luciana Ines Fiszbein, Ana Godoy Herz, Micaela Amalia Muñoz, Manuel Javier Allo, Mariano Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo Alternative splicing Pol II elongation Transcription alpha tropomyosin caspase 9 DNA dystrophin fibronectin histone deacetylase 1 histone deacetylase 2 histone H2A histone H3 histone H4 MED23 protein mediator complex messenger RNA protein bcl x protein tyrosine kinase RNA RNA polymerase II serine small nuclear ribonucleoprotein transactivator protein unclassified drug 3' untranslated region 5' untranslated region alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly chromatin structure exon gene control gene expression genomic instability histone methylation human in vitro study in vivo study intron kinetics nonhuman nucleosome priority journal protein phosphorylation protein synthesis proteomics reverse transcription polymerase chain reaction review RNA sequence RNA synthesis transcription elongation transcription regulation Xenopus yeast Alternative Splicing Animals Chromatin Humans Kinetics Models, Biological Protein Binding RNA Polymerase II Transcription Elongation, Genetic Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of alternative splicing regulation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation. © 2012 Elsevier B.V. Fil:Lafaille, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Petrillo, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gómez Acuña, L.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fiszbein, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Godoy Herz, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Muñoz, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alló, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Schor, I.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18749399_v1829_n1_p134_Dujardin http://hdl.handle.net/20.500.12110/paper_18749399_v1829_n1_p134_Dujardin
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alternative splicing Pol II elongation Transcription alpha tropomyosin caspase 9 DNA dystrophin fibronectin histone deacetylase 1 histone deacetylase 2 histone H2A histone H3 histone H4 MED23 protein mediator complex messenger RNA protein bcl x protein tyrosine kinase RNA RNA polymerase II serine small nuclear ribonucleoprotein transactivator protein unclassified drug 3' untranslated region 5' untranslated region alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly chromatin structure exon gene control gene expression genomic instability histone methylation human in vitro study in vivo study intron kinetics nonhuman nucleosome priority journal protein phosphorylation protein synthesis proteomics reverse transcription polymerase chain reaction review RNA sequence RNA synthesis transcription elongation transcription regulation Xenopus yeast Alternative Splicing Animals Chromatin Humans Kinetics Models, Biological Protein Binding RNA Polymerase II Transcription Elongation, Genetic
spellingShingle	Alternative splicing Pol II elongation Transcription alpha tropomyosin caspase 9 DNA dystrophin fibronectin histone deacetylase 1 histone deacetylase 2 histone H2A histone H3 histone H4 MED23 protein mediator complex messenger RNA protein bcl x protein tyrosine kinase RNA RNA polymerase II serine small nuclear ribonucleoprotein transactivator protein unclassified drug 3' untranslated region 5' untranslated region alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly chromatin structure exon gene control gene expression genomic instability histone methylation human in vitro study in vivo study intron kinetics nonhuman nucleosome priority journal protein phosphorylation protein synthesis proteomics reverse transcription polymerase chain reaction review RNA sequence RNA synthesis transcription elongation transcription regulation Xenopus yeast Alternative Splicing Animals Chromatin Humans Kinetics Models, Biological Protein Binding RNA Polymerase II Transcription Elongation, Genetic Lafaille, Celina Petrillo, Ezequiel Gomez Acuña, Luciana Ines Fiszbein, Ana Godoy Herz, Micaela Amalia Muñoz, Manuel Javier Allo, Mariano Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo Transcriptional elongation and alternative splicing
topic_facet	Alternative splicing Pol II elongation Transcription alpha tropomyosin caspase 9 DNA dystrophin fibronectin histone deacetylase 1 histone deacetylase 2 histone H2A histone H3 histone H4 MED23 protein mediator complex messenger RNA protein bcl x protein tyrosine kinase RNA RNA polymerase II serine small nuclear ribonucleoprotein transactivator protein unclassified drug 3' untranslated region 5' untranslated region alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly chromatin structure exon gene control gene expression genomic instability histone methylation human in vitro study in vivo study intron kinetics nonhuman nucleosome priority journal protein phosphorylation protein synthesis proteomics reverse transcription polymerase chain reaction review RNA sequence RNA synthesis transcription elongation transcription regulation Xenopus yeast Alternative Splicing Animals Chromatin Humans Kinetics Models, Biological Protein Binding RNA Polymerase II Transcription Elongation, Genetic
description	Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of alternative splicing regulation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation. © 2012 Elsevier B.V.
author	Lafaille, Celina Petrillo, Ezequiel Gomez Acuña, Luciana Ines Fiszbein, Ana Godoy Herz, Micaela Amalia Muñoz, Manuel Javier Allo, Mariano Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo
author_facet	Lafaille, Celina Petrillo, Ezequiel Gomez Acuña, Luciana Ines Fiszbein, Ana Godoy Herz, Micaela Amalia Muñoz, Manuel Javier Allo, Mariano Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo
author_sort	Lafaille, Celina
title	Transcriptional elongation and alternative splicing
title_short	Transcriptional elongation and alternative splicing
title_full	Transcriptional elongation and alternative splicing
title_fullStr	Transcriptional elongation and alternative splicing
title_full_unstemmed	Transcriptional elongation and alternative splicing
title_sort	transcriptional elongation and alternative splicing
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18749399_v1829_n1_p134_Dujardin http://hdl.handle.net/20.500.12110/paper_18749399_v1829_n1_p134_Dujardin
work_keys_str_mv	AT lafaillecelina transcriptionalelongationandalternativesplicing AT petrilloezequiel transcriptionalelongationandalternativesplicing AT gomezacunalucianaines transcriptionalelongationandalternativesplicing AT fiszbeinana transcriptionalelongationandalternativesplicing AT godoyherzmicaelaamalia transcriptionalelongationandalternativesplicing AT munozmanueljavier transcriptionalelongationandalternativesplicing AT allomariano transcriptionalelongationandalternativesplicing AT schorignacioesteban transcriptionalelongationandalternativesplicing AT kornblihttalbertorodolfo transcriptionalelongationandalternativesplicing
_version_	1768546371222110208

Transcriptional elongation and alternative splicing

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