Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
Porphyrias neuropathophysiology could be related to low levels of heme as a cofactor for nitric oxide synthase (NOS). We examined how anaesthetics and other porphyrinogenic agents affect mice NOS activity and expression. Brain response was differential depending on the cellular fraction analyzed. Mo...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18723128_v5_n1_p25_Lavandera http://hdl.handle.net/20.500.12110/paper_18723128_v5_n1_p25_Lavandera |
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paper:paper_18723128_v5_n1_p25_Lavandera2023-06-08T16:30:00Z Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs Lavandera, Jimena Verónica Batlle, Alcira María del Carmen Buzaleh, Ana María Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Brain Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus Porphyrias neuropathophysiology could be related to low levels of heme as a cofactor for nitric oxide synthase (NOS). We examined how anaesthetics and other porphyrinogenic agents affect mice NOS activity and expression. Brain response was differential depending on the cellular fraction analyzed. Most of the drugs diminished cytosolic activity. Instead, isoflurane, enflurane and ethanol increased mitochondrial activity. NOS expression also depended on the drug tested. A comparative study was performed in liver. Our present and previous results indicate the widespread action of porphyrinogenic agents in brain, which could be the reason why it is difficult to establish the onset of acute porphyria neurological manifestations. © 2011 Bentham Science Publishers Ltd. Fil:Lavandera, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18723128_v5_n1_p25_Lavandera http://hdl.handle.net/20.500.12110/paper_18723128_v5_n1_p25_Lavandera |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Brain Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus |
| spellingShingle |
Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Brain Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus Lavandera, Jimena Verónica Batlle, Alcira María del Carmen Buzaleh, Ana María Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs |
| topic_facet |
Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Brain Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus |
| description |
Porphyrias neuropathophysiology could be related to low levels of heme as a cofactor for nitric oxide synthase (NOS). We examined how anaesthetics and other porphyrinogenic agents affect mice NOS activity and expression. Brain response was differential depending on the cellular fraction analyzed. Most of the drugs diminished cytosolic activity. Instead, isoflurane, enflurane and ethanol increased mitochondrial activity. NOS expression also depended on the drug tested. A comparative study was performed in liver. Our present and previous results indicate the widespread action of porphyrinogenic agents in brain, which could be the reason why it is difficult to establish the onset of acute porphyria neurological manifestations. © 2011 Bentham Science Publishers Ltd. |
| author |
Lavandera, Jimena Verónica Batlle, Alcira María del Carmen Buzaleh, Ana María |
| author_facet |
Lavandera, Jimena Verónica Batlle, Alcira María del Carmen Buzaleh, Ana María |
| author_sort |
Lavandera, Jimena Verónica |
| title |
Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs |
| title_short |
Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs |
| title_full |
Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs |
| title_fullStr |
Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs |
| title_full_unstemmed |
Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs |
| title_sort |
mice brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18723128_v5_n1_p25_Lavandera http://hdl.handle.net/20.500.12110/paper_18723128_v5_n1_p25_Lavandera |
| work_keys_str_mv |
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| _version_ |
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