Adiponectin and waist circumference as predictors of insulin-resistance in women

Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an h...

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Publicado:	2014
Materias:	Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause adiponectin antihypertensive agent C reactive protein glucose high density lipoprotein cholesterol insulin triacylglycerol adult aged article blood pressure body mass cardiovascular risk cholesterol blood level diastolic blood pressure female glucose blood level human hypertension insulin blood level insulin resistance major clinical study male middle aged obesity postmenopause premenopause priority journal protein blood level systolic blood pressure triacylglycerol blood level waist circumference Adult Age Factors Aged Argentina Biological Markers Blood Glucose Blood Pressure C-Reactive Protein Cholesterol Female Humans Insulin Insulin Resistance Luminescent Measurements Male Middle Aged Prevalence Risk Factors Statistics, Nonparametric Waist Circumference
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18714021_v8_n1_p3_Bonneau http://hdl.handle.net/20.500.12110/paper_18714021_v8_n1_p3_Bonneau
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_18714021_v8_n1_p3_Bonneau
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spelling	paper:paper_18714021_v8_n1_p3_Bonneau2023-06-08T16:29:57Z Adiponectin and waist circumference as predictors of insulin-resistance in women Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause adiponectin antihypertensive agent C reactive protein glucose high density lipoprotein cholesterol insulin triacylglycerol adult aged article blood pressure body mass cardiovascular risk cholesterol blood level diastolic blood pressure female glucose blood level human hypertension insulin blood level insulin resistance major clinical study male middle aged obesity postmenopause premenopause priority journal protein blood level systolic blood pressure triacylglycerol blood level waist circumference Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause Adiponectin Adult Age Factors Aged Argentina Biological Markers Blood Glucose Blood Pressure C-Reactive Protein Cholesterol Female Humans Insulin Insulin Resistance Luminescent Measurements Male Middle Aged Prevalence Risk Factors Statistics, Nonparametric Waist Circumference Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an healthy urban middle age population and to explore the role of adiponectin, inflammatory biomarkers (hs-CRP) and traditional cardiovascular risk factors as predictors of the insulin-resistance state. Materials and methods: We studied of 176 participants (117 women and 59 men, 25-74 years), individuals with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal, or hepatic neoplasms and pregnant women were excluded. We evaluated glucose, insulin, adiponectin and hs-CRP. Results: We found that 17.2% of individuals presented insulin-resistance. Correlation was found between waist circumference, body mass index, blood pressure and HOMA index (p < 0.01). Adiponectin was associated with the insulin-resistance (p < 0.001) but not hs-CRP. Adiponectin (β = 0.385, p = 0.004) and waist circumference (β = 0.116, p = 0.02) were predictors of IR only in women, meanwhile none of the analyzed biomarkers predicted insulin-resistance in men. Besides, postmenopausal women presented higher adiponectin levels than premenopausal 7.63 (4.46-9.58) vs 5.50 (3.83-7.40) μg/ml, p = 0.01. Conclusions: Adiponectin and waist circumference are important predictors of insulin-resistance even in healthy non-diabetic women, they may open a new opportunity to improve current risk estimation. © 2013 Diabetes. Published by Elsevier Ltd. All rights reserved. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18714021_v8_n1_p3_Bonneau http://hdl.handle.net/20.500.12110/paper_18714021_v8_n1_p3_Bonneau
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause adiponectin antihypertensive agent C reactive protein glucose high density lipoprotein cholesterol insulin triacylglycerol adult aged article blood pressure body mass cardiovascular risk cholesterol blood level diastolic blood pressure female glucose blood level human hypertension insulin blood level insulin resistance major clinical study male middle aged obesity postmenopause premenopause priority journal protein blood level systolic blood pressure triacylglycerol blood level waist circumference Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause Adiponectin Adult Age Factors Aged Argentina Biological Markers Blood Glucose Blood Pressure C-Reactive Protein Cholesterol Female Humans Insulin Insulin Resistance Luminescent Measurements Male Middle Aged Prevalence Risk Factors Statistics, Nonparametric Waist Circumference
spellingShingle	Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause adiponectin antihypertensive agent C reactive protein glucose high density lipoprotein cholesterol insulin triacylglycerol adult aged article blood pressure body mass cardiovascular risk cholesterol blood level diastolic blood pressure female glucose blood level human hypertension insulin blood level insulin resistance major clinical study male middle aged obesity postmenopause premenopause priority journal protein blood level systolic blood pressure triacylglycerol blood level waist circumference Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause Adiponectin Adult Age Factors Aged Argentina Biological Markers Blood Glucose Blood Pressure C-Reactive Protein Cholesterol Female Humans Insulin Insulin Resistance Luminescent Measurements Male Middle Aged Prevalence Risk Factors Statistics, Nonparametric Waist Circumference Adiponectin and waist circumference as predictors of insulin-resistance in women
topic_facet	Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause adiponectin antihypertensive agent C reactive protein glucose high density lipoprotein cholesterol insulin triacylglycerol adult aged article blood pressure body mass cardiovascular risk cholesterol blood level diastolic blood pressure female glucose blood level human hypertension insulin blood level insulin resistance major clinical study male middle aged obesity postmenopause premenopause priority journal protein blood level systolic blood pressure triacylglycerol blood level waist circumference Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause Adiponectin Adult Age Factors Aged Argentina Biological Markers Blood Glucose Blood Pressure C-Reactive Protein Cholesterol Female Humans Insulin Insulin Resistance Luminescent Measurements Male Middle Aged Prevalence Risk Factors Statistics, Nonparametric Waist Circumference
description	Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an healthy urban middle age population and to explore the role of adiponectin, inflammatory biomarkers (hs-CRP) and traditional cardiovascular risk factors as predictors of the insulin-resistance state. Materials and methods: We studied of 176 participants (117 women and 59 men, 25-74 years), individuals with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal, or hepatic neoplasms and pregnant women were excluded. We evaluated glucose, insulin, adiponectin and hs-CRP. Results: We found that 17.2% of individuals presented insulin-resistance. Correlation was found between waist circumference, body mass index, blood pressure and HOMA index (p < 0.01). Adiponectin was associated with the insulin-resistance (p < 0.001) but not hs-CRP. Adiponectin (β = 0.385, p = 0.004) and waist circumference (β = 0.116, p = 0.02) were predictors of IR only in women, meanwhile none of the analyzed biomarkers predicted insulin-resistance in men. Besides, postmenopausal women presented higher adiponectin levels than premenopausal 7.63 (4.46-9.58) vs 5.50 (3.83-7.40) μg/ml, p = 0.01. Conclusions: Adiponectin and waist circumference are important predictors of insulin-resistance even in healthy non-diabetic women, they may open a new opportunity to improve current risk estimation. © 2013 Diabetes. Published by Elsevier Ltd. All rights reserved.
title	Adiponectin and waist circumference as predictors of insulin-resistance in women
title_short	Adiponectin and waist circumference as predictors of insulin-resistance in women
title_full	Adiponectin and waist circumference as predictors of insulin-resistance in women
title_fullStr	Adiponectin and waist circumference as predictors of insulin-resistance in women
title_full_unstemmed	Adiponectin and waist circumference as predictors of insulin-resistance in women
title_sort	adiponectin and waist circumference as predictors of insulin-resistance in women
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18714021_v8_n1_p3_Bonneau http://hdl.handle.net/20.500.12110/paper_18714021_v8_n1_p3_Bonneau
_version_	1768541771831181312

Adiponectin and waist circumference as predictors of insulin-resistance in women

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