Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation
Far beyond its role in reproduction., progesterone exerts neuroprotective., promyelinating, and anti-inflammatory effects in the nervous system. These effects are amplified under pathological conditions., implying that changes of the local environment sensitize nervous tissues to steroid therapy. Th...
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2011
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paper:paper_18681883_v7_n3_p403_Deniselle2023-06-08T16:29:52Z Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation experimental autoimmune encephalomyelitis motoneuron degeneration neuroinflammation neuroprotection progesterone Wobbler mouse amyloid precursor protein cell nucleus receptor growth associated protein membrane receptor neurotrophin progesterone sex hormone amyotrophic lateral sclerosis axon clinical trial (topic) demyelination disease severity drug effect enzyme metabolism evidence based practice experimental autoimmune encephalomyelitis human long term care motoneuron motoneuron degeneration motoneuron degeneration motor neuron disease multicenter study (topic) multiple sclerosis muscle strength nerve cell degeneration nervous system inflammation neuroprotection neurotransmission nonhuman priority journal protein expression relapse Review survival rate Far beyond its role in reproduction., progesterone exerts neuroprotective., promyelinating, and anti-inflammatory effects in the nervous system. These effects are amplified under pathological conditions., implying that changes of the local environment sensitize nervous tissues to steroid therapy. The present survey covers our results of progesterone neu-roprotection in a motoneuron neurodegeneration model and a neuroinflammation model. In the degenerating spinal cord of the Wobbler mouse., progesterone reverses the impaired expression of neurotrophins., increases enzymes of neu-rotransmission and metabolism., prevents oxidative damage of motoneurons and their vacuolar degeneration (paraptosis), and attenuates the development of mitochondrial abnormalities. After long-term treatment., progesterone also increases muscle strength and the survival of Wobbler mice. Subsequently., this review describes the effects of progesterone in mice with induced experimental autoimmune encephalomyelitis (EAE), a commonly used model of multiple sclerosis. In EAE mice., progesterone attenuates the clinical severity., decreases demy-elination and neuronal dysfunction., increases axonal counts., reduces the formation of amyloid precursor protein profiles., and decreases the aberrant expression of growth-associated proteins. These actions of progesterone may be due to multiple mechanisms., considering that classic nuclear receptors., extranuclear receptors., and membrane receptors are all expressed in the spinal cord. Although many aspects of progesterone action in humans remain unsolved., data provided by experimental models makes getting to this objective closer than previously expected. © 2011, by Walter de Gruyter Berlin Boston. All rights reserved. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18681883_v7_n3_p403_Deniselle http://hdl.handle.net/20.500.12110/paper_18681883_v7_n3_p403_Deniselle |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
experimental autoimmune encephalomyelitis motoneuron degeneration neuroinflammation neuroprotection progesterone Wobbler mouse amyloid precursor protein cell nucleus receptor growth associated protein membrane receptor neurotrophin progesterone sex hormone amyotrophic lateral sclerosis axon clinical trial (topic) demyelination disease severity drug effect enzyme metabolism evidence based practice experimental autoimmune encephalomyelitis human long term care motoneuron motoneuron degeneration motoneuron degeneration motor neuron disease multicenter study (topic) multiple sclerosis muscle strength nerve cell degeneration nervous system inflammation neuroprotection neurotransmission nonhuman priority journal protein expression relapse Review survival rate |
| spellingShingle |
experimental autoimmune encephalomyelitis motoneuron degeneration neuroinflammation neuroprotection progesterone Wobbler mouse amyloid precursor protein cell nucleus receptor growth associated protein membrane receptor neurotrophin progesterone sex hormone amyotrophic lateral sclerosis axon clinical trial (topic) demyelination disease severity drug effect enzyme metabolism evidence based practice experimental autoimmune encephalomyelitis human long term care motoneuron motoneuron degeneration motoneuron degeneration motor neuron disease multicenter study (topic) multiple sclerosis muscle strength nerve cell degeneration nervous system inflammation neuroprotection neurotransmission nonhuman priority journal protein expression relapse Review survival rate Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation |
| topic_facet |
experimental autoimmune encephalomyelitis motoneuron degeneration neuroinflammation neuroprotection progesterone Wobbler mouse amyloid precursor protein cell nucleus receptor growth associated protein membrane receptor neurotrophin progesterone sex hormone amyotrophic lateral sclerosis axon clinical trial (topic) demyelination disease severity drug effect enzyme metabolism evidence based practice experimental autoimmune encephalomyelitis human long term care motoneuron motoneuron degeneration motoneuron degeneration motor neuron disease multicenter study (topic) multiple sclerosis muscle strength nerve cell degeneration nervous system inflammation neuroprotection neurotransmission nonhuman priority journal protein expression relapse Review survival rate |
| description |
Far beyond its role in reproduction., progesterone exerts neuroprotective., promyelinating, and anti-inflammatory effects in the nervous system. These effects are amplified under pathological conditions., implying that changes of the local environment sensitize nervous tissues to steroid therapy. The present survey covers our results of progesterone neu-roprotection in a motoneuron neurodegeneration model and a neuroinflammation model. In the degenerating spinal cord of the Wobbler mouse., progesterone reverses the impaired expression of neurotrophins., increases enzymes of neu-rotransmission and metabolism., prevents oxidative damage of motoneurons and their vacuolar degeneration (paraptosis), and attenuates the development of mitochondrial abnormalities. After long-term treatment., progesterone also increases muscle strength and the survival of Wobbler mice. Subsequently., this review describes the effects of progesterone in mice with induced experimental autoimmune encephalomyelitis (EAE), a commonly used model of multiple sclerosis. In EAE mice., progesterone attenuates the clinical severity., decreases demy-elination and neuronal dysfunction., increases axonal counts., reduces the formation of amyloid precursor protein profiles., and decreases the aberrant expression of growth-associated proteins. These actions of progesterone may be due to multiple mechanisms., considering that classic nuclear receptors., extranuclear receptors., and membrane receptors are all expressed in the spinal cord. Although many aspects of progesterone action in humans remain unsolved., data provided by experimental models makes getting to this objective closer than previously expected. © 2011, by Walter de Gruyter Berlin Boston. All rights reserved. |
| title |
Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation |
| title_short |
Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation |
| title_full |
Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation |
| title_fullStr |
Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation |
| title_full_unstemmed |
Experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation |
| title_sort |
experimental and clinical evidence for the protective role of progesterone in motoneuron degeneration and neuroinflammation |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18681883_v7_n3_p403_Deniselle http://hdl.handle.net/20.500.12110/paper_18681883_v7_n3_p403_Deniselle |
| _version_ |
1768546693872091136 |