Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication
The study of virus-host interactions is a major goal in molecular virology and provides new effective targets for antiviral therapies. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a group of cellular RNA-binding proteins localized predominantly within the nucleus, which participate i...
Guardado en:
| Autores principales: | , |
|---|---|
| Publicado: |
2012
|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17460794_v7_n6_p575_Castilla http://hdl.handle.net/20.500.12110/paper_17460794_v7_n6_p575_Castilla |
| Aporte de: |
| id |
paper:paper_17460794_v7_n6_p575_Castilla |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_17460794_v7_n6_p575_Castilla2023-06-08T16:28:25Z Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication Castilla, Viviana Scolaro, Luis Alberto heterogeneous nuclear ribonucleoprotein hnRNP PCBP PTB replication RNA splicing translation virus genomic RNA guanosine triphosphatase heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein a heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein e2 heterogeneous nuclear ribonucleoprotein I heterogeneous nuclear ribonucleoprotein q nonstructural protein 5 protein p62 Ran protein unclassified drug virus protein avian influenza virus cell division cellular distribution Coronavirus Coxsackie virus Dengue virus Flavivirus gene silencing Herpes virus host pathogen interaction human Human immunodeficiency virus 1 Human papillomavirus type 16 immune response in vitro study in vivo study Japanese encephalitis virus nonhuman Orthomyxovirus Papilloma virus pathogenesis Picornavirus picornavirus infection poliomyelitis Poliomyelitis virus priority journal protein expression protein interaction review Rhabdovirus Rhinovirus RNA processing RNA replication RNA splicing RNA synthesis RNA translation Sindbis virus Togavirus virogenesis virus replication Arenaviridae Coronaviridae Flaviviridae Herpesviridae Orthomyxoviridae Papillomaviridae Picornaviridae Retroviridae Rhabdoviridae Togaviridae The study of virus-host interactions is a major goal in molecular virology and provides new effective targets for antiviral therapies. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a group of cellular RNA-binding proteins localized predominantly within the nucleus, which participate in gene transcription and subsequent RNA post-transcriptional modifications. The interaction between hnRNPs and viral components was extensively demonstrated, as well as the ability of virus infections to alter the intracellular localization or the level of expression of different hnRNPs. The involvement of these proteins in the replication of numerous viruses including members from the Retroviridae, Flaviviridae, Coronaviridae, Arenaviridae, Rhabdoviridae, Papillomaviridae, Orthomyxoviridae, Picornaviridae, Togaviridae and Herpesviridae families, has been reported. In order to gain an increased understanding of the interactions between virus and cell that result in the productive infection of the latter, in this review we discuss the main findings about the role of hnRNPs in different steps of viral replication, such as RNA synthesis, translation, RNA processing and egress of newly assembled progeny virus. © 2012 Future Medicine Ltd. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Scolaro, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17460794_v7_n6_p575_Castilla http://hdl.handle.net/20.500.12110/paper_17460794_v7_n6_p575_Castilla |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
heterogeneous nuclear ribonucleoprotein hnRNP PCBP PTB replication RNA splicing translation virus genomic RNA guanosine triphosphatase heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein a heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein e2 heterogeneous nuclear ribonucleoprotein I heterogeneous nuclear ribonucleoprotein q nonstructural protein 5 protein p62 Ran protein unclassified drug virus protein avian influenza virus cell division cellular distribution Coronavirus Coxsackie virus Dengue virus Flavivirus gene silencing Herpes virus host pathogen interaction human Human immunodeficiency virus 1 Human papillomavirus type 16 immune response in vitro study in vivo study Japanese encephalitis virus nonhuman Orthomyxovirus Papilloma virus pathogenesis Picornavirus picornavirus infection poliomyelitis Poliomyelitis virus priority journal protein expression protein interaction review Rhabdovirus Rhinovirus RNA processing RNA replication RNA splicing RNA synthesis RNA translation Sindbis virus Togavirus virogenesis virus replication Arenaviridae Coronaviridae Flaviviridae Herpesviridae Orthomyxoviridae Papillomaviridae Picornaviridae Retroviridae Rhabdoviridae Togaviridae |
| spellingShingle |
heterogeneous nuclear ribonucleoprotein hnRNP PCBP PTB replication RNA splicing translation virus genomic RNA guanosine triphosphatase heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein a heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein e2 heterogeneous nuclear ribonucleoprotein I heterogeneous nuclear ribonucleoprotein q nonstructural protein 5 protein p62 Ran protein unclassified drug virus protein avian influenza virus cell division cellular distribution Coronavirus Coxsackie virus Dengue virus Flavivirus gene silencing Herpes virus host pathogen interaction human Human immunodeficiency virus 1 Human papillomavirus type 16 immune response in vitro study in vivo study Japanese encephalitis virus nonhuman Orthomyxovirus Papilloma virus pathogenesis Picornavirus picornavirus infection poliomyelitis Poliomyelitis virus priority journal protein expression protein interaction review Rhabdovirus Rhinovirus RNA processing RNA replication RNA splicing RNA synthesis RNA translation Sindbis virus Togavirus virogenesis virus replication Arenaviridae Coronaviridae Flaviviridae Herpesviridae Orthomyxoviridae Papillomaviridae Picornaviridae Retroviridae Rhabdoviridae Togaviridae Castilla, Viviana Scolaro, Luis Alberto Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication |
| topic_facet |
heterogeneous nuclear ribonucleoprotein hnRNP PCBP PTB replication RNA splicing translation virus genomic RNA guanosine triphosphatase heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein a heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein e2 heterogeneous nuclear ribonucleoprotein I heterogeneous nuclear ribonucleoprotein q nonstructural protein 5 protein p62 Ran protein unclassified drug virus protein avian influenza virus cell division cellular distribution Coronavirus Coxsackie virus Dengue virus Flavivirus gene silencing Herpes virus host pathogen interaction human Human immunodeficiency virus 1 Human papillomavirus type 16 immune response in vitro study in vivo study Japanese encephalitis virus nonhuman Orthomyxovirus Papilloma virus pathogenesis Picornavirus picornavirus infection poliomyelitis Poliomyelitis virus priority journal protein expression protein interaction review Rhabdovirus Rhinovirus RNA processing RNA replication RNA splicing RNA synthesis RNA translation Sindbis virus Togavirus virogenesis virus replication Arenaviridae Coronaviridae Flaviviridae Herpesviridae Orthomyxoviridae Papillomaviridae Picornaviridae Retroviridae Rhabdoviridae Togaviridae |
| description |
The study of virus-host interactions is a major goal in molecular virology and provides new effective targets for antiviral therapies. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a group of cellular RNA-binding proteins localized predominantly within the nucleus, which participate in gene transcription and subsequent RNA post-transcriptional modifications. The interaction between hnRNPs and viral components was extensively demonstrated, as well as the ability of virus infections to alter the intracellular localization or the level of expression of different hnRNPs. The involvement of these proteins in the replication of numerous viruses including members from the Retroviridae, Flaviviridae, Coronaviridae, Arenaviridae, Rhabdoviridae, Papillomaviridae, Orthomyxoviridae, Picornaviridae, Togaviridae and Herpesviridae families, has been reported. In order to gain an increased understanding of the interactions between virus and cell that result in the productive infection of the latter, in this review we discuss the main findings about the role of hnRNPs in different steps of viral replication, such as RNA synthesis, translation, RNA processing and egress of newly assembled progeny virus. © 2012 Future Medicine Ltd. |
| author |
Castilla, Viviana Scolaro, Luis Alberto |
| author_facet |
Castilla, Viviana Scolaro, Luis Alberto |
| author_sort |
Castilla, Viviana |
| title |
Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication |
| title_short |
Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication |
| title_full |
Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication |
| title_fullStr |
Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication |
| title_full_unstemmed |
Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication |
| title_sort |
involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17460794_v7_n6_p575_Castilla http://hdl.handle.net/20.500.12110/paper_17460794_v7_n6_p575_Castilla |
| work_keys_str_mv |
AT castillaviviana involvementofheterogeneousnuclearribonucleoproteinsinviralmultiplication AT scolaroluisalberto involvementofheterogeneousnuclearribonucleoproteinsinviralmultiplication |
| _version_ |
1768544750579744768 |