The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Result...
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2016
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17456150_v11_n1_p_ChavesFerreira http://hdl.handle.net/20.500.12110/paper_17456150_v11_n1_p_ChavesFerreira |
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paper:paper_17456150_v11_n1_p_ChavesFerreira2023-06-08T16:28:23Z The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells Cell cycle D cyclins Hematopoiesis Ccnd1 protein, mouse Ccnd2 protein, mouse Ccnd3 protein, mouse cyclin D1 cyclin D2 cyclin D3 animal cell differentiation cell division genetics hematopoiesis metabolism mouse transgenic mouse Animals Cell Differentiation Cell Division Cyclin D1 Cyclin D2 Cyclin D3 Hematopoiesis Mice Mice, Transgenic Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results: Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4-5, since hematopoietic differentiation is also blocked by the conditional ablation of this region. Conclusion: These results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis. © 2016 Chaves-Ferreira et al. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17456150_v11_n1_p_ChavesFerreira http://hdl.handle.net/20.500.12110/paper_17456150_v11_n1_p_ChavesFerreira |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cell cycle D cyclins Hematopoiesis Ccnd1 protein, mouse Ccnd2 protein, mouse Ccnd3 protein, mouse cyclin D1 cyclin D2 cyclin D3 animal cell differentiation cell division genetics hematopoiesis metabolism mouse transgenic mouse Animals Cell Differentiation Cell Division Cyclin D1 Cyclin D2 Cyclin D3 Hematopoiesis Mice Mice, Transgenic |
| spellingShingle |
Cell cycle D cyclins Hematopoiesis Ccnd1 protein, mouse Ccnd2 protein, mouse Ccnd3 protein, mouse cyclin D1 cyclin D2 cyclin D3 animal cell differentiation cell division genetics hematopoiesis metabolism mouse transgenic mouse Animals Cell Differentiation Cell Division Cyclin D1 Cyclin D2 Cyclin D3 Hematopoiesis Mice Mice, Transgenic The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells |
| topic_facet |
Cell cycle D cyclins Hematopoiesis Ccnd1 protein, mouse Ccnd2 protein, mouse Ccnd3 protein, mouse cyclin D1 cyclin D2 cyclin D3 animal cell differentiation cell division genetics hematopoiesis metabolism mouse transgenic mouse Animals Cell Differentiation Cell Division Cyclin D1 Cyclin D2 Cyclin D3 Hematopoiesis Mice Mice, Transgenic |
| description |
Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results: Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4-5, since hematopoietic differentiation is also blocked by the conditional ablation of this region. Conclusion: These results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis. © 2016 Chaves-Ferreira et al. |
| title |
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells |
| title_short |
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells |
| title_full |
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells |
| title_fullStr |
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells |
| title_full_unstemmed |
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells |
| title_sort |
cyclin d1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17456150_v11_n1_p_ChavesFerreira http://hdl.handle.net/20.500.12110/paper_17456150_v11_n1_p_ChavesFerreira |
| _version_ |
1768545302472556544 |